Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

Interferon-λ (IFN-λ) acts on mucosal epithelial cells and thereby confers direct antiviral protection. In contrast, the role of IFN-λ in adaptive immunity is far less clear. Here, we report that mice deficient in IFN-λ signaling exhibited impaired CD8 + T cell and antibody responses after infection...

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Veröffentlicht in:	Nature immunology 2019-05, Vol.20 (5), p.593-601
Hauptverfasser:	Ye, Liang, Schnepf, Daniel, Becker, Jan, Ebert, Karolina, Tanriver, Yakup, Bernasconi, Valentina, Gad, Hans Henrik, Hartmann, Rune, Lycke, Nils, Staeheli, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/127 631/250/2152 631/250/254 631/250/347 Adaptive immunity Adaptive Immunity - drug effects Adaptive Immunity - genetics Adaptive Immunity - immunology Animals Antibody Formation - drug effects Antibody Formation - immunology Biomedical and Life Sciences Biomedicine CD8 antigen Cell migration Cells, Cultured Cytokines - genetics Cytokines - immunology Cytokines - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - virology Epithelial cells Immunity, Mucosal - drug effects Immunity, Mucosal - genetics Immunity, Mucosal - immunology Immunization Immunization - methods Immunoglobulin A Immunoglobulin G Immunoglobulins Immunology Infectious Diseases Influenza Influenza A virus - drug effects Influenza A virus - immunology Influenza A virus - physiology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Interferon Interleukins - administration & dosage Interleukins - immunology Lymph nodes Lymphocytes Lymphocytes T M cells Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Mucosal immunity Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Receptors, Interferon - genetics Receptors, Interferon - immunology Receptors, Interferon - metabolism Thymic stromal lymphopoietin Thymus Vaccines Viruses
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