Disulfide‐Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA

Development of intracellular delivery methods for antisense DNA and siRNA is important. Previously reported methods using liposomes or receptor‐ligands take several hours or more to deliver oligonucleotides to the cytoplasm due to their retention in endosomes. Oligonucleotides modified with low mole...

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Veröffentlicht in:	Angewandte Chemie International Edition 2019-05, Vol.58 (20), p.6611-6615
Hauptverfasser:	Shu, Zhaoma, Tanaka, Iku, Ota, Azumi, Fushihara, Daichi, Abe, Naoko, Kawaguchi, Saki, Nakamoto, Kosuke, Tomoike, Fumiaki, Tada, Seiichi, Ito, Yoshihiro, Kimura, Yasuaki, Abe, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	antisense Antisense DNA cellular uptake Conjugation Cytoplasm cytosolic delivery Deoxyribonucleic acid disulfide DNA Endocytosis Endosomes Internalization Liposomes Low molecular weights Molecular weight Oligonucleotides siRNA
Online-Zugang:	Volltext
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