PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma

The prevention and treatment of metastatic sarcoma are areas of significant unmet need. Immune checkpoint inhibitor monotherapy has shown little activity in sarcoma and there is great interest in identifying novel treatment combinations that may augment responses. and , we investigated the potential...

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Veröffentlicht in:	Clinical cancer research 2019-06, Vol.25 (11), p.3443-3454
Hauptverfasser:	Smith, Henry G, Mansfield, David, Roulstone, Victoria, Kyula-Currie, Joan N, McLaughlin, Martin, Patel, Radhika R, Bergerhoff, Katharina F, Paget, James T, Dillon, Magnus T, Khan, Aadil, Melcher, Alan, Thway, Khin, Harrington, Kevin J, Hayes, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Immunological - pharmacology Cell Line, Tumor Disease Models, Animal Genetic Therapy Humans Immunohistochemistry Immunophenotyping Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Mice Oncolytic Virotherapy Oncolytic Viruses - genetics Programmed Cell Death 1 Receptor - antagonists & inhibitors Sarcoma - etiology Sarcoma - metabolism Sarcoma - pathology Sarcoma - therapy T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Treatment Outcome Vaccinia virus - genetics Xenograft Model Antitumor Assays
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