Clinical correlates of HLA‐B27 and its subtypes in enthesitis‐related arthritis variant of juvenile idiopathic arthritis in south Indian Tamil patients
Aim The aim of the study was to assess the distribution of human leukocyte antigen (HLA)‐B*27 subtypes and its correlation with disease phenotypes in children with enthesitis‐related arthritis variant of juvenile idiopathic arthritis (JIA‐ERA). Method One hundred and sixty patients (132 males, 28 fe...
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| Veröffentlicht in: | International journal of rheumatic diseases 2019-07, Vol.22 (7), p.1289-1296 |
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| creator | Kavadichanda, Chengappa G. Seth, Gaurav Kumar, Gunjan Gulati, Reena Negi, Vir Singh |
| description | Aim
The aim of the study was to assess the distribution of human leukocyte antigen (HLA)‐B*27 subtypes and its correlation with disease phenotypes in children with enthesitis‐related arthritis variant of juvenile idiopathic arthritis (JIA‐ERA).
Method
One hundred and sixty patients (132 males, 28 females) satisfying the International League Against Rheumatism (ILAR) classification criteria for JIA‐ERA were assessed and relevant demographic, clinical and radiographic data were documented. HLA‐B*27 typing was done for all the patients and B*27 positive samples were subjected to high‐resolution gene sequencing. The effect of duration of illness, HLA‐B*27, its subtypes, and gender on the clinical phenotype were analyzed.
Results
The mean age of disease onset was 12.69 ± 2.4 years with a male:female ratio of 4.7:1.0. HLA‐B*27 was positive in 109/160 patients and HLA‐B*27:04 was detected in 63% followed by B*27:05 (30%). Duration of illness was greater in patients with skeletal deformity, hip arthritis, sacroiliitis, cervical spine involvement and acute anterior uveitis (AAU) (P |
| doi_str_mv | 10.1111/1756-185X.13551 |
| format | Article |
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The aim of the study was to assess the distribution of human leukocyte antigen (HLA)‐B*27 subtypes and its correlation with disease phenotypes in children with enthesitis‐related arthritis variant of juvenile idiopathic arthritis (JIA‐ERA).
Method
One hundred and sixty patients (132 males, 28 females) satisfying the International League Against Rheumatism (ILAR) classification criteria for JIA‐ERA were assessed and relevant demographic, clinical and radiographic data were documented. HLA‐B*27 typing was done for all the patients and B*27 positive samples were subjected to high‐resolution gene sequencing. The effect of duration of illness, HLA‐B*27, its subtypes, and gender on the clinical phenotype were analyzed.
Results
The mean age of disease onset was 12.69 ± 2.4 years with a male:female ratio of 4.7:1.0. HLA‐B*27 was positive in 109/160 patients and HLA‐B*27:04 was detected in 63% followed by B*27:05 (30%). Duration of illness was greater in patients with skeletal deformity, hip arthritis, sacroiliitis, cervical spine involvement and acute anterior uveitis (AAU) (P < 0.05). HLA‐B*27 positivity was associated with a prolonged course of disease, higher incidence of AAU (14.7% vs 2%, P = 0.015), family history of spondyloarthritis (21.1% vs 5.9%; P = 0.015) and higher erythrocyte sedimentation rate as compared to HLA‐B*27 negative patients (P < 0.01). The HLA‐B*27:04 and *27:05 positive patients had similar clinical phenotypes.
Conclusion
Presence of HLA‐B*27 and long duration of illness results in skeletal deformity, hip arthritis, sacroiliitis, cervical spine involvement and AAU. HLA‐B*27:04 followed by B*27:05 are the most common HLA‐B*27 subtypes in our study population and both have a similar clinical phenotype.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.13551</identifier><identifier>PMID: 30884197</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Age Factors ; Arthritis ; Arthritis, Juvenile - diagnosis ; Arthritis, Juvenile - epidemiology ; Arthritis, Juvenile - genetics ; Arthritis, Juvenile - immunology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Disease Progression ; enthesitis ; Erythrocyte sedimentation rate ; Female ; Genetic Predisposition to Disease ; Hip ; Histocompatibility antigen HLA ; HLA ; HLA-B27 Antigen - genetics ; HLA-B27 Antigen - immunology ; Humans ; Illnesses ; India - epidemiology ; Inflammatory diseases ; JIA ; Male ; pediatric ; Phenotype ; Phenotypes ; Population studies ; Prognosis ; Rheumatic diseases ; Risk Assessment ; Risk Factors ; Sacroiliitis ; south Indian Tamils ; Spine (cervical) ; Time Factors ; Tissue typing ; Uveitis</subject><ispartof>International journal of rheumatic diseases, 2019-07, Vol.22 (7), p.1289-1296</ispartof><rights>2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><rights>2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3711-9d122d735451b77d675fc570b87fc145a1a4e5bb9005c36c5ca0ea3506cb9d203</citedby><cites>FETCH-LOGICAL-c3711-9d122d735451b77d675fc570b87fc145a1a4e5bb9005c36c5ca0ea3506cb9d203</cites><orcidid>0000-0003-1518-6031 ; 0000-0002-3643-3989</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1756-185X.13551$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1756-185X.13551$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30884197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kavadichanda, Chengappa G.</creatorcontrib><creatorcontrib>Seth, Gaurav</creatorcontrib><creatorcontrib>Kumar, Gunjan</creatorcontrib><creatorcontrib>Gulati, Reena</creatorcontrib><creatorcontrib>Negi, Vir Singh</creatorcontrib><title>Clinical correlates of HLA‐B27 and its subtypes in enthesitis‐related arthritis variant of juvenile idiopathic arthritis in south Indian Tamil patients</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Aim
The aim of the study was to assess the distribution of human leukocyte antigen (HLA)‐B*27 subtypes and its correlation with disease phenotypes in children with enthesitis‐related arthritis variant of juvenile idiopathic arthritis (JIA‐ERA).
Method
One hundred and sixty patients (132 males, 28 females) satisfying the International League Against Rheumatism (ILAR) classification criteria for JIA‐ERA were assessed and relevant demographic, clinical and radiographic data were documented. HLA‐B*27 typing was done for all the patients and B*27 positive samples were subjected to high‐resolution gene sequencing. The effect of duration of illness, HLA‐B*27, its subtypes, and gender on the clinical phenotype were analyzed.
Results
The mean age of disease onset was 12.69 ± 2.4 years with a male:female ratio of 4.7:1.0. HLA‐B*27 was positive in 109/160 patients and HLA‐B*27:04 was detected in 63% followed by B*27:05 (30%). Duration of illness was greater in patients with skeletal deformity, hip arthritis, sacroiliitis, cervical spine involvement and acute anterior uveitis (AAU) (P < 0.05). HLA‐B*27 positivity was associated with a prolonged course of disease, higher incidence of AAU (14.7% vs 2%, P = 0.015), family history of spondyloarthritis (21.1% vs 5.9%; P = 0.015) and higher erythrocyte sedimentation rate as compared to HLA‐B*27 negative patients (P < 0.01). The HLA‐B*27:04 and *27:05 positive patients had similar clinical phenotypes.
Conclusion
Presence of HLA‐B*27 and long duration of illness results in skeletal deformity, hip arthritis, sacroiliitis, cervical spine involvement and AAU. HLA‐B*27:04 followed by B*27:05 are the most common HLA‐B*27 subtypes in our study population and both have a similar clinical phenotype.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - diagnosis</subject><subject>Arthritis, Juvenile - epidemiology</subject><subject>Arthritis, Juvenile - genetics</subject><subject>Arthritis, Juvenile - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>enthesitis</subject><subject>Erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Hip</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA</subject><subject>HLA-B27 Antigen - genetics</subject><subject>HLA-B27 Antigen - immunology</subject><subject>Humans</subject><subject>Illnesses</subject><subject>India - epidemiology</subject><subject>Inflammatory diseases</subject><subject>JIA</subject><subject>Male</subject><subject>pediatric</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Population studies</subject><subject>Prognosis</subject><subject>Rheumatic diseases</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sacroiliitis</subject><subject>south Indian Tamils</subject><subject>Spine (cervical)</subject><subject>Time Factors</subject><subject>Tissue typing</subject><subject>Uveitis</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFPHCEcxUlTU63tuTdD0ksvq_xhGHaO202tJpvoQZPeCANMls0sswKzZm_9CL377fwkMo5uTC9ygTx-70H-D6FvQE4hrzMQvJzAlP85BcY5fEBHe-Xj_lzAIfoc44qQElgpPqFDRqZZrcQRepi3zjutWqy7EGyrko24a_DFYvb4999PKrDyBrsUcezrtNvkW-ex9Wlpo0suZmh0GaxCWoZBw1sVnPJpyFn1W-tda7EzrtuotHT6DZijYtenJb70JjvwjVq7FmfM5RfiF3TQqDbary_7Mbo9_3Uzv5gsrn5fzmeLiWYCYFIZoNQIxgsOtRCmFLzRXJB6KhoNBVegCsvruiKEa1ZqrhWxinFS6roylLBj9GPM3YTurrcxybWL2rat8rbro6RQFXm8lEFGv_-Hrro--Pw7SWlJRMkKKjJ1NlI6dDEG28hNcGsVdhKIHHqTQzNyaEk-95YdJy-5fb22Zs-_FpUBPgL3eZi79_Lk7HoxBj8BQgGl7g</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Kavadichanda, Chengappa G.</creator><creator>Seth, Gaurav</creator><creator>Kumar, Gunjan</creator><creator>Gulati, Reena</creator><creator>Negi, Vir Singh</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1518-6031</orcidid><orcidid>https://orcid.org/0000-0002-3643-3989</orcidid></search><sort><creationdate>201907</creationdate><title>Clinical correlates of HLA‐B27 and its subtypes in enthesitis‐related arthritis variant of juvenile idiopathic arthritis in south Indian Tamil patients</title><author>Kavadichanda, Chengappa G. ; Seth, Gaurav ; Kumar, Gunjan ; Gulati, Reena ; Negi, Vir Singh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3711-9d122d735451b77d675fc570b87fc145a1a4e5bb9005c36c5ca0ea3506cb9d203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Arthritis</topic><topic>Arthritis, Juvenile - diagnosis</topic><topic>Arthritis, Juvenile - epidemiology</topic><topic>Arthritis, Juvenile - genetics</topic><topic>Arthritis, Juvenile - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>enthesitis</topic><topic>Erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Hip</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA</topic><topic>HLA-B27 Antigen - genetics</topic><topic>HLA-B27 Antigen - immunology</topic><topic>Humans</topic><topic>Illnesses</topic><topic>India - epidemiology</topic><topic>Inflammatory diseases</topic><topic>JIA</topic><topic>Male</topic><topic>pediatric</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Population studies</topic><topic>Prognosis</topic><topic>Rheumatic diseases</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sacroiliitis</topic><topic>south Indian Tamils</topic><topic>Spine (cervical)</topic><topic>Time Factors</topic><topic>Tissue typing</topic><topic>Uveitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kavadichanda, Chengappa G.</creatorcontrib><creatorcontrib>Seth, Gaurav</creatorcontrib><creatorcontrib>Kumar, Gunjan</creatorcontrib><creatorcontrib>Gulati, Reena</creatorcontrib><creatorcontrib>Negi, Vir Singh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kavadichanda, Chengappa G.</au><au>Seth, Gaurav</au><au>Kumar, Gunjan</au><au>Gulati, Reena</au><au>Negi, Vir Singh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical correlates of HLA‐B27 and its subtypes in enthesitis‐related arthritis variant of juvenile idiopathic arthritis in south Indian Tamil patients</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2019-07</date><risdate>2019</risdate><volume>22</volume><issue>7</issue><spage>1289</spage><epage>1296</epage><pages>1289-1296</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Aim
The aim of the study was to assess the distribution of human leukocyte antigen (HLA)‐B*27 subtypes and its correlation with disease phenotypes in children with enthesitis‐related arthritis variant of juvenile idiopathic arthritis (JIA‐ERA).
Method
One hundred and sixty patients (132 males, 28 females) satisfying the International League Against Rheumatism (ILAR) classification criteria for JIA‐ERA were assessed and relevant demographic, clinical and radiographic data were documented. HLA‐B*27 typing was done for all the patients and B*27 positive samples were subjected to high‐resolution gene sequencing. The effect of duration of illness, HLA‐B*27, its subtypes, and gender on the clinical phenotype were analyzed.
Results
The mean age of disease onset was 12.69 ± 2.4 years with a male:female ratio of 4.7:1.0. HLA‐B*27 was positive in 109/160 patients and HLA‐B*27:04 was detected in 63% followed by B*27:05 (30%). Duration of illness was greater in patients with skeletal deformity, hip arthritis, sacroiliitis, cervical spine involvement and acute anterior uveitis (AAU) (P < 0.05). HLA‐B*27 positivity was associated with a prolonged course of disease, higher incidence of AAU (14.7% vs 2%, P = 0.015), family history of spondyloarthritis (21.1% vs 5.9%; P = 0.015) and higher erythrocyte sedimentation rate as compared to HLA‐B*27 negative patients (P < 0.01). The HLA‐B*27:04 and *27:05 positive patients had similar clinical phenotypes.
Conclusion
Presence of HLA‐B*27 and long duration of illness results in skeletal deformity, hip arthritis, sacroiliitis, cervical spine involvement and AAU. HLA‐B*27:04 followed by B*27:05 are the most common HLA‐B*27 subtypes in our study population and both have a similar clinical phenotype.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30884197</pmid><doi>10.1111/1756-185X.13551</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1518-6031</orcidid><orcidid>https://orcid.org/0000-0002-3643-3989</orcidid></addata></record> |
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| subjects | Adolescent Age Factors Arthritis Arthritis, Juvenile - diagnosis Arthritis, Juvenile - epidemiology Arthritis, Juvenile - genetics Arthritis, Juvenile - immunology Child Child, Preschool Cross-Sectional Studies Disease Progression enthesitis Erythrocyte sedimentation rate Female Genetic Predisposition to Disease Hip Histocompatibility antigen HLA HLA HLA-B27 Antigen - genetics HLA-B27 Antigen - immunology Humans Illnesses India - epidemiology Inflammatory diseases JIA Male pediatric Phenotype Phenotypes Population studies Prognosis Rheumatic diseases Risk Assessment Risk Factors Sacroiliitis south Indian Tamils Spine (cervical) Time Factors Tissue typing Uveitis |
| title | Clinical correlates of HLA‐B27 and its subtypes in enthesitis‐related arthritis variant of juvenile idiopathic arthritis in south Indian Tamil patients |
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