Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction
Purpose Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruc...
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| Veröffentlicht in: | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2019-11, Vol.27 (11), p.3567-3574 |
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| container_title | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA |
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| creator | Ushio, Tetsuro Okazaki, Ken Osaki, Kanji Takayama, Yukihisa Sagiyama, Koji Mizu-uchi, Hideki Hamai, Satoshi Akasaki, Yukio Honda, Hiroshi Nakashima, Yasuharu |
| description | Purpose
Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruction by comparing T1ρ values before and 2 years after surgery and investigate whether surgical factors and clinical outcomes are related to differences in T1ρ values.
Methods
Fifty patients who underwent unilateral primary ACL reconstruction were evaluated using T1ρ mapping before and 2 years after surgery. Three regions of interest (ROIs) were defined in the cartilage associated with the medial (M) and lateral (L) weight-bearing areas of the femoral condyle (FC) (anterior: MFC1 and LFC1, middle: MFC2 and LFC2, and posterior: MFC3 and LFC3). Two ROIs associated with the tibial plateau (T) were defined (anterior: MT1 and LT1, and posterior: MT2 and LT2). T1ρ values within the ROIs were measured before and 2 years after surgery and compared using the paired
t
test. Correlations between the difference in T1ρ values at these two time points and patient characteristics, presence of a cartilaginous lesion, graft type, and postoperative anteroposterior laxity were also evaluated using Pearson’s and Spearman’s correlation coefficients.
Results
There was a significant increase in T1ρ before versus 2 years after surgery in the MT1, MT2, LFC1, and LT1 areas, and a significant decrease in the LFC3 and LT2 areas. There was a significant correlation between postoperative anterior-posterior laxity and a postoperative increase in T1ρ values in the MFC3 (
r
= 0.37,
P
= 0.013) and MT2 (
r
= 0.35,
P
= 0.021) areas. Increases in T1ρ values in the MFC2 area were negatively correlated with KOOS symptoms (
ρ
= − 0.349,
P
= 0.027) and quality of life (
ρ
= − 0.374,
P
= 0.017) subscale scores.
Conclusion
Early degenerative changes in medial articular cartilage were observed with T1ρ mapping at 2 years after ACL reconstruction. Postoperative anterior-posterior laxity is correlated with an increase in T1ρ values in the posteromedial femur and tibia. An increase in T1ρ values in the central medial femoral condyle was associated with knee symptoms.
Level of evidence
III. |
| doi_str_mv | 10.1007/s00167-019-05468-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2193607710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2193607710</sourcerecordid><originalsourceid>FETCH-LOGICAL-p213t-8ca6eabee52b395254567da4d5fbcfc5f54eeaff88d9114b7b85f89f7a29c3693</originalsourceid><addsrcrecordid>eNpdkUFPHSEUhYlpo0_bP9CFIenGzVQYYBiWRm1tYuJG1-QO7_LEzjBPYJr678vzaZp0c7nhfpxcziHkC2ffOGP6PDPGO90wbhqmZNc36oCsuBSi0ULqD2TFjGyblqnuiBzn_MRYbaU5JEeC9dpwzlbkzxVuMGKCEn4jdY8QN5hpiNRBKmGEDdIx_MLxhc7OLWk3KY9IJ1wHGKmbp23lJoyFgi-YKMRaw5yoS4sLUHbPN_AKJHRzzKXelzDHT-SjhzHj57fzhDx8v76_vGlu7378vLy4bbYtF6XpHXQIA6JqB2FUq6Tq9BrkWvnBeae8kojgfd-v64fkoIde-d54Da1xojPihJztdbdpfl4wFzuF7HAcIeK8ZNtyIzqmNWcV_fof-jQvKdbtdhQ3kmkpK3X6Ri1DtcFuU5ggvdh3Tysg9kCuo2pn-ifDmd0lZ_fJ2ZqcfU3OKvEXIKiL3A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2191940744</pqid></control><display><type>article</type><title>Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction</title><source>MEDLINE</source><source>Wiley Journals</source><source>SpringerLink Journals</source><creator>Ushio, Tetsuro ; Okazaki, Ken ; Osaki, Kanji ; Takayama, Yukihisa ; Sagiyama, Koji ; Mizu-uchi, Hideki ; Hamai, Satoshi ; Akasaki, Yukio ; Honda, Hiroshi ; Nakashima, Yasuharu</creator><creatorcontrib>Ushio, Tetsuro ; Okazaki, Ken ; Osaki, Kanji ; Takayama, Yukihisa ; Sagiyama, Koji ; Mizu-uchi, Hideki ; Hamai, Satoshi ; Akasaki, Yukio ; Honda, Hiroshi ; Nakashima, Yasuharu</creatorcontrib><description>Purpose
Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruction by comparing T1ρ values before and 2 years after surgery and investigate whether surgical factors and clinical outcomes are related to differences in T1ρ values.
Methods
Fifty patients who underwent unilateral primary ACL reconstruction were evaluated using T1ρ mapping before and 2 years after surgery. Three regions of interest (ROIs) were defined in the cartilage associated with the medial (M) and lateral (L) weight-bearing areas of the femoral condyle (FC) (anterior: MFC1 and LFC1, middle: MFC2 and LFC2, and posterior: MFC3 and LFC3). Two ROIs associated with the tibial plateau (T) were defined (anterior: MT1 and LT1, and posterior: MT2 and LT2). T1ρ values within the ROIs were measured before and 2 years after surgery and compared using the paired
t
test. Correlations between the difference in T1ρ values at these two time points and patient characteristics, presence of a cartilaginous lesion, graft type, and postoperative anteroposterior laxity were also evaluated using Pearson’s and Spearman’s correlation coefficients.
Results
There was a significant increase in T1ρ before versus 2 years after surgery in the MT1, MT2, LFC1, and LT1 areas, and a significant decrease in the LFC3 and LT2 areas. There was a significant correlation between postoperative anterior-posterior laxity and a postoperative increase in T1ρ values in the MFC3 (
r
= 0.37,
P
= 0.013) and MT2 (
r
= 0.35,
P
= 0.021) areas. Increases in T1ρ values in the MFC2 area were negatively correlated with KOOS symptoms (
ρ
= − 0.349,
P
= 0.027) and quality of life (
ρ
= − 0.374,
P
= 0.017) subscale scores.
Conclusion
Early degenerative changes in medial articular cartilage were observed with T1ρ mapping at 2 years after ACL reconstruction. Postoperative anterior-posterior laxity is correlated with an increase in T1ρ values in the posteromedial femur and tibia. An increase in T1ρ values in the central medial femoral condyle was associated with knee symptoms.
Level of evidence
III.</description><identifier>ISSN: 0942-2056</identifier><identifier>EISSN: 1433-7347</identifier><identifier>DOI: 10.1007/s00167-019-05468-5</identifier><identifier>PMID: 30879110</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Anterior cruciate ligament ; Anterior Cruciate Ligament Injuries - pathology ; Anterior Cruciate Ligament Injuries - surgery ; Anterior Cruciate Ligament Reconstruction - adverse effects ; Cartilage ; Cartilage (articular) ; Cartilage, Articular - diagnostic imaging ; Cartilage, Articular - metabolism ; Cartilage, Articular - pathology ; Cartilage, Articular - surgery ; Correlation coefficients ; Female ; Femur ; Femur - diagnostic imaging ; Glycosaminoglycans ; Glycosaminoglycans - metabolism ; Humans ; Joint Instability - etiology ; Knee ; Magnetic Resonance Imaging ; Male ; Mapping ; Medicine ; Medicine & Public Health ; Middle Aged ; Orthopedics ; Postoperative Complications - pathology ; Quality of Life ; Signs and symptoms ; Surgery ; Tibia ; Tibia - diagnostic imaging ; Weight ; Weight-Bearing ; Young Adult</subject><ispartof>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019-11, Vol.27 (11), p.3567-3574</ispartof><rights>European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2019</rights><rights>Knee Surgery, Sports Traumatology, Arthroscopy is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p213t-8ca6eabee52b395254567da4d5fbcfc5f54eeaff88d9114b7b85f89f7a29c3693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00167-019-05468-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00167-019-05468-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30879110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ushio, Tetsuro</creatorcontrib><creatorcontrib>Okazaki, Ken</creatorcontrib><creatorcontrib>Osaki, Kanji</creatorcontrib><creatorcontrib>Takayama, Yukihisa</creatorcontrib><creatorcontrib>Sagiyama, Koji</creatorcontrib><creatorcontrib>Mizu-uchi, Hideki</creatorcontrib><creatorcontrib>Hamai, Satoshi</creatorcontrib><creatorcontrib>Akasaki, Yukio</creatorcontrib><creatorcontrib>Honda, Hiroshi</creatorcontrib><creatorcontrib>Nakashima, Yasuharu</creatorcontrib><title>Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction</title><title>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</title><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><description>Purpose
Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruction by comparing T1ρ values before and 2 years after surgery and investigate whether surgical factors and clinical outcomes are related to differences in T1ρ values.
Methods
Fifty patients who underwent unilateral primary ACL reconstruction were evaluated using T1ρ mapping before and 2 years after surgery. Three regions of interest (ROIs) were defined in the cartilage associated with the medial (M) and lateral (L) weight-bearing areas of the femoral condyle (FC) (anterior: MFC1 and LFC1, middle: MFC2 and LFC2, and posterior: MFC3 and LFC3). Two ROIs associated with the tibial plateau (T) were defined (anterior: MT1 and LT1, and posterior: MT2 and LT2). T1ρ values within the ROIs were measured before and 2 years after surgery and compared using the paired
t
test. Correlations between the difference in T1ρ values at these two time points and patient characteristics, presence of a cartilaginous lesion, graft type, and postoperative anteroposterior laxity were also evaluated using Pearson’s and Spearman’s correlation coefficients.
Results
There was a significant increase in T1ρ before versus 2 years after surgery in the MT1, MT2, LFC1, and LT1 areas, and a significant decrease in the LFC3 and LT2 areas. There was a significant correlation between postoperative anterior-posterior laxity and a postoperative increase in T1ρ values in the MFC3 (
r
= 0.37,
P
= 0.013) and MT2 (
r
= 0.35,
P
= 0.021) areas. Increases in T1ρ values in the MFC2 area were negatively correlated with KOOS symptoms (
ρ
= − 0.349,
P
= 0.027) and quality of life (
ρ
= − 0.374,
P
= 0.017) subscale scores.
Conclusion
Early degenerative changes in medial articular cartilage were observed with T1ρ mapping at 2 years after ACL reconstruction. Postoperative anterior-posterior laxity is correlated with an increase in T1ρ values in the posteromedial femur and tibia. An increase in T1ρ values in the central medial femoral condyle was associated with knee symptoms.
Level of evidence
III.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anterior cruciate ligament</subject><subject>Anterior Cruciate Ligament Injuries - pathology</subject><subject>Anterior Cruciate Ligament Injuries - surgery</subject><subject>Anterior Cruciate Ligament Reconstruction - adverse effects</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage, Articular - diagnostic imaging</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - pathology</subject><subject>Cartilage, Articular - surgery</subject><subject>Correlation coefficients</subject><subject>Female</subject><subject>Femur</subject><subject>Femur - diagnostic imaging</subject><subject>Glycosaminoglycans</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Humans</subject><subject>Joint Instability - etiology</subject><subject>Knee</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mapping</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Postoperative Complications - pathology</subject><subject>Quality of Life</subject><subject>Signs and symptoms</subject><subject>Surgery</subject><subject>Tibia</subject><subject>Tibia - diagnostic imaging</subject><subject>Weight</subject><subject>Weight-Bearing</subject><subject>Young Adult</subject><issn>0942-2056</issn><issn>1433-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkUFPHSEUhYlpo0_bP9CFIenGzVQYYBiWRm1tYuJG1-QO7_LEzjBPYJr678vzaZp0c7nhfpxcziHkC2ffOGP6PDPGO90wbhqmZNc36oCsuBSi0ULqD2TFjGyblqnuiBzn_MRYbaU5JEeC9dpwzlbkzxVuMGKCEn4jdY8QN5hpiNRBKmGEDdIx_MLxhc7OLWk3KY9IJ1wHGKmbp23lJoyFgi-YKMRaw5yoS4sLUHbPN_AKJHRzzKXelzDHT-SjhzHj57fzhDx8v76_vGlu7378vLy4bbYtF6XpHXQIA6JqB2FUq6Tq9BrkWvnBeae8kojgfd-v64fkoIde-d54Da1xojPihJztdbdpfl4wFzuF7HAcIeK8ZNtyIzqmNWcV_fof-jQvKdbtdhQ3kmkpK3X6Ri1DtcFuU5ggvdh3Tysg9kCuo2pn-ifDmd0lZ_fJ2ZqcfU3OKvEXIKiL3A</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Ushio, Tetsuro</creator><creator>Okazaki, Ken</creator><creator>Osaki, Kanji</creator><creator>Takayama, Yukihisa</creator><creator>Sagiyama, Koji</creator><creator>Mizu-uchi, Hideki</creator><creator>Hamai, Satoshi</creator><creator>Akasaki, Yukio</creator><creator>Honda, Hiroshi</creator><creator>Nakashima, Yasuharu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20191101</creationdate><title>Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction</title><author>Ushio, Tetsuro ; Okazaki, Ken ; Osaki, Kanji ; Takayama, Yukihisa ; Sagiyama, Koji ; Mizu-uchi, Hideki ; Hamai, Satoshi ; Akasaki, Yukio ; Honda, Hiroshi ; Nakashima, Yasuharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p213t-8ca6eabee52b395254567da4d5fbcfc5f54eeaff88d9114b7b85f89f7a29c3693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anterior cruciate ligament</topic><topic>Anterior Cruciate Ligament Injuries - pathology</topic><topic>Anterior Cruciate Ligament Injuries - surgery</topic><topic>Anterior Cruciate Ligament Reconstruction - adverse effects</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Cartilage, Articular - diagnostic imaging</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - pathology</topic><topic>Cartilage, Articular - surgery</topic><topic>Correlation coefficients</topic><topic>Female</topic><topic>Femur</topic><topic>Femur - diagnostic imaging</topic><topic>Glycosaminoglycans</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Humans</topic><topic>Joint Instability - etiology</topic><topic>Knee</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mapping</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Postoperative Complications - pathology</topic><topic>Quality of Life</topic><topic>Signs and symptoms</topic><topic>Surgery</topic><topic>Tibia</topic><topic>Tibia - diagnostic imaging</topic><topic>Weight</topic><topic>Weight-Bearing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ushio, Tetsuro</creatorcontrib><creatorcontrib>Okazaki, Ken</creatorcontrib><creatorcontrib>Osaki, Kanji</creatorcontrib><creatorcontrib>Takayama, Yukihisa</creatorcontrib><creatorcontrib>Sagiyama, Koji</creatorcontrib><creatorcontrib>Mizu-uchi, Hideki</creatorcontrib><creatorcontrib>Hamai, Satoshi</creatorcontrib><creatorcontrib>Akasaki, Yukio</creatorcontrib><creatorcontrib>Honda, Hiroshi</creatorcontrib><creatorcontrib>Nakashima, Yasuharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ushio, Tetsuro</au><au>Okazaki, Ken</au><au>Osaki, Kanji</au><au>Takayama, Yukihisa</au><au>Sagiyama, Koji</au><au>Mizu-uchi, Hideki</au><au>Hamai, Satoshi</au><au>Akasaki, Yukio</au><au>Honda, Hiroshi</au><au>Nakashima, Yasuharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction</atitle><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle><stitle>Knee Surg Sports Traumatol Arthrosc</stitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>27</volume><issue>11</issue><spage>3567</spage><epage>3574</epage><pages>3567-3574</pages><issn>0942-2056</issn><eissn>1433-7347</eissn><abstract>Purpose
Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruction by comparing T1ρ values before and 2 years after surgery and investigate whether surgical factors and clinical outcomes are related to differences in T1ρ values.
Methods
Fifty patients who underwent unilateral primary ACL reconstruction were evaluated using T1ρ mapping before and 2 years after surgery. Three regions of interest (ROIs) were defined in the cartilage associated with the medial (M) and lateral (L) weight-bearing areas of the femoral condyle (FC) (anterior: MFC1 and LFC1, middle: MFC2 and LFC2, and posterior: MFC3 and LFC3). Two ROIs associated with the tibial plateau (T) were defined (anterior: MT1 and LT1, and posterior: MT2 and LT2). T1ρ values within the ROIs were measured before and 2 years after surgery and compared using the paired
t
test. Correlations between the difference in T1ρ values at these two time points and patient characteristics, presence of a cartilaginous lesion, graft type, and postoperative anteroposterior laxity were also evaluated using Pearson’s and Spearman’s correlation coefficients.
Results
There was a significant increase in T1ρ before versus 2 years after surgery in the MT1, MT2, LFC1, and LT1 areas, and a significant decrease in the LFC3 and LT2 areas. There was a significant correlation between postoperative anterior-posterior laxity and a postoperative increase in T1ρ values in the MFC3 (
r
= 0.37,
P
= 0.013) and MT2 (
r
= 0.35,
P
= 0.021) areas. Increases in T1ρ values in the MFC2 area were negatively correlated with KOOS symptoms (
ρ
= − 0.349,
P
= 0.027) and quality of life (
ρ
= − 0.374,
P
= 0.017) subscale scores.
Conclusion
Early degenerative changes in medial articular cartilage were observed with T1ρ mapping at 2 years after ACL reconstruction. Postoperative anterior-posterior laxity is correlated with an increase in T1ρ values in the posteromedial femur and tibia. An increase in T1ρ values in the central medial femoral condyle was associated with knee symptoms.
Level of evidence
III.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30879110</pmid><doi>10.1007/s00167-019-05468-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019-11, Vol.27 (11), p.3567-3574 |
| issn | 0942-2056 1433-7347 |
| language | eng |
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| source | MEDLINE; Wiley Journals; SpringerLink Journals |
| subjects | Adolescent Adult Anterior cruciate ligament Anterior Cruciate Ligament Injuries - pathology Anterior Cruciate Ligament Injuries - surgery Anterior Cruciate Ligament Reconstruction - adverse effects Cartilage Cartilage (articular) Cartilage, Articular - diagnostic imaging Cartilage, Articular - metabolism Cartilage, Articular - pathology Cartilage, Articular - surgery Correlation coefficients Female Femur Femur - diagnostic imaging Glycosaminoglycans Glycosaminoglycans - metabolism Humans Joint Instability - etiology Knee Magnetic Resonance Imaging Male Mapping Medicine Medicine & Public Health Middle Aged Orthopedics Postoperative Complications - pathology Quality of Life Signs and symptoms Surgery Tibia Tibia - diagnostic imaging Weight Weight-Bearing Young Adult |
| title | Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction |
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