An ALP-activatable and mitochondria-targeted probe for prostate cancer-specific bimodal imaging and aggregation-enhanced photothermal therapy
Tumor-derived alkaline phosphatase (ALP) is over-expressed in metastatic prostate cancer. The development of selective probes for ALP detection is therefore critical for early diagnosis and therapy of metastatic prostate cancer. Herein, we develop a mitochondria-targeted near-infrared activatable fl...
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| Veröffentlicht in: | Nanoscale 2019-03, Vol.11 (13), p.6307-6314 |
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| container_title | Nanoscale |
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| creator | Yao, Defan Yang, Shuyan Wang, Yanshu Bian, Kexin Yang, Weitao Wang, Dengbin Zhang, Bingbo |
| description | Tumor-derived alkaline phosphatase (ALP) is over-expressed in metastatic prostate cancer. The development of selective probes for ALP detection is therefore critical for early diagnosis and therapy of metastatic prostate cancer. Herein, we develop a mitochondria-targeted near-infrared activatable fluorescent/photoacoustic (NIR FL/PA) probe for the selective detection of prostate cancer-derived ALP and aggregation-enhanced photothermal therapy. Upon dephosphorylation, the probes are activated and they provide a red-shifted strong absorption and emission in the NIR window and thus enable NIR FL and PA imaging of ALP activity in tumor tissues. Particularly, the activated probes self-assemble in situ into a supramolecular network structure which induces cell apoptosis and significantly enhances the photothermal therapy efficacy. |
| doi_str_mv | 10.1039/c9nr00913b |
| format | Article |
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The development of selective probes for ALP detection is therefore critical for early diagnosis and therapy of metastatic prostate cancer. Herein, we develop a mitochondria-targeted near-infrared activatable fluorescent/photoacoustic (NIR FL/PA) probe for the selective detection of prostate cancer-derived ALP and aggregation-enhanced photothermal therapy. Upon dephosphorylation, the probes are activated and they provide a red-shifted strong absorption and emission in the NIR window and thus enable NIR FL and PA imaging of ALP activity in tumor tissues. 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The development of selective probes for ALP detection is therefore critical for early diagnosis and therapy of metastatic prostate cancer. Herein, we develop a mitochondria-targeted near-infrared activatable fluorescent/photoacoustic (NIR FL/PA) probe for the selective detection of prostate cancer-derived ALP and aggregation-enhanced photothermal therapy. Upon dephosphorylation, the probes are activated and they provide a red-shifted strong absorption and emission in the NIR window and thus enable NIR FL and PA imaging of ALP activity in tumor tissues. Particularly, the activated probes self-assemble in situ into a supramolecular network structure which induces cell apoptosis and significantly enhances the photothermal therapy efficacy.</description><subject>Agglomeration</subject><subject>Alkaline phosphatase</subject><subject>Apoptosis</subject><subject>Fluorescence</subject><subject>Medical imaging</subject><subject>Metastasis</subject><subject>Mitochondria</subject><subject>Prostate cancer</subject><subject>Therapy</subject><subject>Tumors</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkU-LFDEQxYMo7h-9-AGkwYsIremkO5Mcx0FXYVARPTeVpNKTpTsZk4ywH8LvbHp33YOneodfPareI-RFR992lKt3RoVEqeq4fkTOGe1py_mGPX7Qoj8jFzlfUyoUF_wpOeNUSiZ5f07-bEOz3X9rwRT_GwroGRsItll8ieYQg00e2gJpwoK2OaaosXExrSoXKNgYCAZTm49ovPOm0X6JFubGLzD5MN2awTQlnKD4GFoMh3Wjeh1iieWAaan0OuF484w8cTBnfH4_L8nPjx9-7D61-69Xn3fbfWv4IErLFB20ElRvQDLu7KB76qyyQIUzw2Cp2xhwkjtuZMfRsU4DG1jPxIDWSeSX5PWdb33j1wlzGRefDc4zBIynPLKuBkW5GLqKvvoPvY6nFOp1KyVFrxiXlXpzR5maS07oxmOqCaSbsaPjWtK4U1--35b0vsIv7y1PekH7gP5rhf8FY0iPQg</recordid><startdate>20190328</startdate><enddate>20190328</enddate><creator>Yao, Defan</creator><creator>Yang, Shuyan</creator><creator>Wang, Yanshu</creator><creator>Bian, Kexin</creator><creator>Yang, Weitao</creator><creator>Wang, Dengbin</creator><creator>Zhang, Bingbo</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0806-2487</orcidid><orcidid>https://orcid.org/0000-0001-5848-9863</orcidid><orcidid>https://orcid.org/0000-0002-0981-7071</orcidid></search><sort><creationdate>20190328</creationdate><title>An ALP-activatable and mitochondria-targeted probe for prostate cancer-specific bimodal imaging and aggregation-enhanced photothermal therapy</title><author>Yao, Defan ; Yang, Shuyan ; Wang, Yanshu ; Bian, Kexin ; Yang, Weitao ; Wang, Dengbin ; Zhang, Bingbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-2905b960b7a823fd5b40fd9da06fc55d0f7caf83f3c813ef21ba2524265edf8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Agglomeration</topic><topic>Alkaline phosphatase</topic><topic>Apoptosis</topic><topic>Fluorescence</topic><topic>Medical imaging</topic><topic>Metastasis</topic><topic>Mitochondria</topic><topic>Prostate cancer</topic><topic>Therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Defan</creatorcontrib><creatorcontrib>Yang, Shuyan</creatorcontrib><creatorcontrib>Wang, Yanshu</creatorcontrib><creatorcontrib>Bian, Kexin</creatorcontrib><creatorcontrib>Yang, Weitao</creatorcontrib><creatorcontrib>Wang, Dengbin</creatorcontrib><creatorcontrib>Zhang, Bingbo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Defan</au><au>Yang, Shuyan</au><au>Wang, Yanshu</au><au>Bian, Kexin</au><au>Yang, Weitao</au><au>Wang, Dengbin</au><au>Zhang, Bingbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An ALP-activatable and mitochondria-targeted probe for prostate cancer-specific bimodal imaging and aggregation-enhanced photothermal therapy</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2019-03-28</date><risdate>2019</risdate><volume>11</volume><issue>13</issue><spage>6307</spage><epage>6314</epage><pages>6307-6314</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Tumor-derived alkaline phosphatase (ALP) is over-expressed in metastatic prostate cancer. The development of selective probes for ALP detection is therefore critical for early diagnosis and therapy of metastatic prostate cancer. Herein, we develop a mitochondria-targeted near-infrared activatable fluorescent/photoacoustic (NIR FL/PA) probe for the selective detection of prostate cancer-derived ALP and aggregation-enhanced photothermal therapy. Upon dephosphorylation, the probes are activated and they provide a red-shifted strong absorption and emission in the NIR window and thus enable NIR FL and PA imaging of ALP activity in tumor tissues. 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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Agglomeration Alkaline phosphatase Apoptosis Fluorescence Medical imaging Metastasis Mitochondria Prostate cancer Therapy Tumors |
| title | An ALP-activatable and mitochondria-targeted probe for prostate cancer-specific bimodal imaging and aggregation-enhanced photothermal therapy |
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