Engineering a uniaxial substrate-stretching device for simultaneous electrophysiological measurements and imaging of strained peripheral neurons

•Description and characterisation of novel neuron-stretching device.•Device design allows simultaneous cell straining and electrophysiological measurements.•Results show compatibility with patch clamping, calcium imaging and 3D imaging.•Microgrooved substrates align cells to imitate PNS environment....

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Veröffentlicht in:	Medical engineering & physics 2019-05, Vol.67, p.1-10
Hauptverfasser:	Bianchi, Fabio, George, Julian H., Malboubi, Majid, Jerusalem, Antoine, Thompson, Mark S., Ye, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium imaging Nerve damage Patch clamping Peripheral nerve Uniaxial strain
Online-Zugang:	Volltext
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