Is lymph node dissection necessary for resectable intrahepatic cholangiocarcinoma? A systematic review and meta-analysis

The objective of this meta-analysis was to evaluate the effectiveness and safety of lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC). A literature search with a date range of January 2000 to January 2018 was performed to identify studies comparing lymph node dissect...

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Veröffentlicht in:HPB (Oxford, England) England), 2019-07, Vol.21 (7), p.784-792
Hauptverfasser: Zhou, Rui, Lu, Dihan, Li, Wenda, Tan, Wenliang, Zhu, Sicong, Chen, Xianqing, Min, Jun, Shang, Changzhen, Chen, Yajin
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Sprache:eng
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Zusammenfassung:The objective of this meta-analysis was to evaluate the effectiveness and safety of lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC). A literature search with a date range of January 2000 to January 2018 was performed to identify studies comparing lymph node dissection (LND+) with non-lymph node dissection (LND-) for patients with ICC. The LND + group was further divided into positive (LND + N+) and negative (LND + N-) lymph node status groups based on pathological analysis. 13 studies including 1377 patients were eligible. There were no significant differences in overall survival (OS) (HR 1.13, 95% CI 0.94–1.36; P = 0.20), disease-free survival (DFS) (HR 1.23, 95% CI 0.94–1.60; P = 0.13), or recurrence (OR 1.39, 95% CI 0.90–2.15; P = 0.14) between LND + group and LND-group. Postoperative morbidity was significantly higher in the LND + group (OR 2.67, 95% CI 1.74–4.10; P 
ISSN:1365-182X
1477-2574
DOI:10.1016/j.hpb.2018.12.011