Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2

Cells require energy for homeostatic activities, growth and division. By utilizing glucose as the main energy source, cells generate ATP and metabolic precursors through glycolysis and citric acid cycle. Although the oxidative phosphorylation can produce more ATP molecules from one molecule of gluco...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-04, Vol.512 (1), p.93-99
Hauptverfasser:	Kang, Mingyu, Lee, Sang Min, Kim, Wanil, Lee, Kyung-Ha, Kim, Do-Yeon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobic glycolysis Animals Cell Proliferation Cell Survival DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Fubp1 Glucose - metabolism Glycolysis Hexokinase - genetics Hexokinase - metabolism Humans Lactate Lactic Acid - metabolism Male Mice Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology NIH 3T3 Cells Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism Tumor Up-Regulation
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