Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms

Mesenchymal neoplasms of the uterus (corpus and cervix) encompass a heterogeneous group of tumors with differing morphologies, immunophenotypes and molecular alterations. With the advent of modern molecular techniques, such as next generation sequencing, newly defined genetic abnormalities are being...

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Veröffentlicht in:	Modern pathology 2019-07, Vol.32 (7), p.1008-1022
Hauptverfasser:	Croce, Sabrina, Hostein, Isabelle, Longacre, Teri A., Mills, Anne M., Pérot, Gaëlle, Devouassoux-Shisheboran, Mojgan, Velasco, Valérie, Floquet, Anne, Guyon, Frédéric, Chakiba, Camille, Querleu, Denis, Khalifa, Emmanuel, Mayeur, Laetitia, Rebier, Flora, Leguellec, Sophie, Soubeyran, Isabelle, McCluggage, W. Glenn
Format:	Artikel
Sprache:	eng
Schlagworte:	14/32 45/91 631/67/69 692/53 692/53/2421 96/1 Adult Aged, 80 and over CD34 antigen Cervix Collagen (type I) Collagen Type I - genetics Collagen Type I, alpha 1 Chain Dermatofibrosarcoma protuberans Endometrium Female Fibrosarcoma Fibrosarcoma - diagnosis Fibrosarcoma - genetics Fibrosarcoma - pathology Gene Rearrangement Humans Laboratory Medicine Medicine Medicine & Public Health Mesenchyme Middle Aged Morphology Next-generation sequencing Oncogene Fusion Pathology Peripheral nerves Proto-Oncogene Proteins c-sis - genetics Ribonucleic acid RNA Sarcoma Tumors Uterine cancer Uterine Neoplasms - diagnosis Uterine Neoplasms - genetics Uterine Neoplasms - pathology Uterus Vagina Vaginal Neoplasms - diagnosis Vaginal Neoplasms - genetics Vaginal Neoplasms - pathology Young Adult
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