BDNF-mediated mitophagy alleviates high-glucose-induced brain microvascular endothelial cell injury

Endothelial cell dysfunction and diabetic vascular complications are intrinsically linked. Although BDNF plays a protective role in cerebral microvascular complications caused by diabetes, the mechanisms of this activity are not fully clear. In this study, we investigated the role of BDNF in the hyp...

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Veröffentlicht in:	Apoptosis (London) 2019-06, Vol.24 (5-6), p.511-528
Hauptverfasser:	Jin, Hong, Zhu, Yi, Li, Yiping, Ding, Xiuyu, Ma, Wenqi, Han, Xiqiong, Wang, Bilei
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects B cells Biochemistry Biomedical and Life Sciences Biomedicine BNIP3 protein Brain Brain - blood supply Brain - pathology Brain injury Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - pharmacology Calcium (mitochondrial) Cancer Research Cell Biology Cell injury Cell Line Cell Survival - drug effects Cellular signal transduction Complications and side effects Dextrose Diabetes mellitus Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Gene Expression Glucose Glucose - metabolism Humans Hyperglycemia Hyperglycemia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Membrane Glycoproteins - metabolism Membrane potential Membrane Proteins - metabolism Mice Microvasculature Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial permeability transition pore Mitophagy Mitophagy - drug effects Mitophagy - physiology Oncology Oxidative stress Oxidative Stress - drug effects Phagocytosis Proto-Oncogene Proteins - metabolism Receptor, trkB - metabolism Signal Transduction Transmission electron microscopy TrkB receptors Type 2 diabetes Virology
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