A more flattened bone tunnel has a positive effect on tendon–bone healing in the early period after ACL reconstruction
Purpose The purpose of this study was to evaluate whether a flattened bone tunnel has a positive effect on the tendon–bone healing (TBH) process in the early period after anterior cruciate ligament (ACL) reconstruction. Methods Seventy-two New Zealand White rabbits were randomly allocated into two g...
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| Veröffentlicht in: | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2019-11, Vol.27 (11), p.3543-3551 |
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| creator | Zhao, Fengyuan Hu, Xiaoqing Zhang, Jiahao Shi, Weili Ren, Bo Huang, Hongjie Ao, Yingfang |
| description | Purpose
The purpose of this study was to evaluate whether a flattened bone tunnel has a positive effect on the tendon–bone healing (TBH) process in the early period after anterior cruciate ligament (ACL) reconstruction.
Methods
Seventy-two New Zealand White rabbits were randomly allocated into two groups, the flattened tunnel (FT) group and the conventional round tunnel (RT) group. We compared the cross-sectional areas and diameters of the bone tunnels between the two groups through computed tomography (CT) scanning. TBH results between the two groups were assessed by histological analysis, micro-CT scanning and biomechanical tests at 4 weeks, 8 weeks and 12 weeks after operation.
Results
The cross-sectional areas of the bone tunnels between the two groups were almost the same. However, the shape of bone tunnels in the FT group was more flattened. A faster cellular and collagen remoulding process were found in the FT group. Semiquantitative histological analysis of Safranin O staining showed that there was more fibrocartilage formation in the interface region in the FT group (
P
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| doi_str_mv | 10.1007/s00167-019-05420-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2193169430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2193169430</sourcerecordid><originalsourceid>FETCH-LOGICAL-p213t-7fe6ae1fddee645ac8270eefb754e523a8e876127f9701aec3fcd9e53cbc43233</originalsourceid><addsrcrecordid>eNpd0c1qGzEQB3BREhrH7Qv0EAS59LLJ6GNX3qMxaRsw9JKehawd2RvW0kbSlvjWd8gb9kmixCmFnGZgfgzD_An5wuCKAajrBMAaVQFrK6glh0p9IDMmhaiUkOqEzKCVvOJQN2fkPKV7gNLK9iM5E7BQSjA1I49Lug8RqRtMzuixo5vgkebJexzoziRq6BhSn_vfSNE5tJkGTwvtgv_75-lV79AMvd_Svgx2hZk4HOiIsQ8dNS5jpMvVmka0waccJ5v74D-RU2eGhJ_f6pz8-nZzt_pRrX9-v10t19XImciVctgYZK7rEBtZG7vgChDdRtUSay7MAheqYVy5VgEzaIWzXYu1sBsrBRdiTr4e944xPEyYst73yeIwGI9hSpqzVrCmlQIKvXxH78MUfbnuRTEFEmRd1MWbmjZ77PQY-72JB_3vpwWII0hl5LcY_69hoF-S08fkdElOvyanlXgGFO2K7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2191704045</pqid></control><display><type>article</type><title>A more flattened bone tunnel has a positive effect on tendon–bone healing in the early period after ACL reconstruction</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Access via Wiley Online Library</source><creator>Zhao, Fengyuan ; Hu, Xiaoqing ; Zhang, Jiahao ; Shi, Weili ; Ren, Bo ; Huang, Hongjie ; Ao, Yingfang</creator><creatorcontrib>Zhao, Fengyuan ; Hu, Xiaoqing ; Zhang, Jiahao ; Shi, Weili ; Ren, Bo ; Huang, Hongjie ; Ao, Yingfang</creatorcontrib><description>Purpose
The purpose of this study was to evaluate whether a flattened bone tunnel has a positive effect on the tendon–bone healing (TBH) process in the early period after anterior cruciate ligament (ACL) reconstruction.
Methods
Seventy-two New Zealand White rabbits were randomly allocated into two groups, the flattened tunnel (FT) group and the conventional round tunnel (RT) group. We compared the cross-sectional areas and diameters of the bone tunnels between the two groups through computed tomography (CT) scanning. TBH results between the two groups were assessed by histological analysis, micro-CT scanning and biomechanical tests at 4 weeks, 8 weeks and 12 weeks after operation.
Results
The cross-sectional areas of the bone tunnels between the two groups were almost the same. However, the shape of bone tunnels in the FT group was more flattened. A faster cellular and collagen remoulding process were found in the FT group. Semiquantitative histological analysis of Safranin O staining showed that there was more fibrocartilage formation in the interface region in the FT group (
P
< 0.05). Sirius Red staining showed that the tissues in the interface areas were more intense in the FT group. Micro-CT scanning showed that more new bone formation could be found in the interface region in the FT group. The biomechanical tests also showed that FT ACL reconstruction will result in a stronger regenerated tendon–bone interface.
Conclusions
Our study found that a flattened bone tunnel accelerated TBH in the early period after ACL reconstruction surgery in a rabbit model, which lays the groundwork for further clinical practice of this ACL reconstruction method.</description><identifier>ISSN: 0942-2056</identifier><identifier>EISSN: 1433-7347</identifier><identifier>DOI: 10.1007/s00167-019-05420-7</identifier><identifier>PMID: 30877317</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Anterior cruciate ligament ; Anterior Cruciate Ligament - surgery ; Anterior Cruciate Ligament Reconstruction - methods ; Biomechanical engineering ; Biomechanics ; Bone and Bones - physiology ; Bone and Bones - surgery ; Bone growth ; Bone healing ; Bone surgery ; Collagen ; Collagen - biosynthesis ; Computed tomography ; Fibrocartilage - physiology ; Flattening ; Healing ; Knee ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Models, Animal ; Orthopedics ; Osteogenesis ; Rabbits ; Random Allocation ; Scanning ; Staining ; Tendons - physiology ; Tendons - surgery ; Tunnels ; Wound Healing</subject><ispartof>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019-11, Vol.27 (11), p.3543-3551</ispartof><rights>European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2019</rights><rights>Knee Surgery, Sports Traumatology, Arthroscopy is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p213t-7fe6ae1fddee645ac8270eefb754e523a8e876127f9701aec3fcd9e53cbc43233</cites><orcidid>0000-0002-8909-2022</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00167-019-05420-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00167-019-05420-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30877317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Fengyuan</creatorcontrib><creatorcontrib>Hu, Xiaoqing</creatorcontrib><creatorcontrib>Zhang, Jiahao</creatorcontrib><creatorcontrib>Shi, Weili</creatorcontrib><creatorcontrib>Ren, Bo</creatorcontrib><creatorcontrib>Huang, Hongjie</creatorcontrib><creatorcontrib>Ao, Yingfang</creatorcontrib><title>A more flattened bone tunnel has a positive effect on tendon–bone healing in the early period after ACL reconstruction</title><title>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</title><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><description>Purpose
The purpose of this study was to evaluate whether a flattened bone tunnel has a positive effect on the tendon–bone healing (TBH) process in the early period after anterior cruciate ligament (ACL) reconstruction.
Methods
Seventy-two New Zealand White rabbits were randomly allocated into two groups, the flattened tunnel (FT) group and the conventional round tunnel (RT) group. We compared the cross-sectional areas and diameters of the bone tunnels between the two groups through computed tomography (CT) scanning. TBH results between the two groups were assessed by histological analysis, micro-CT scanning and biomechanical tests at 4 weeks, 8 weeks and 12 weeks after operation.
Results
The cross-sectional areas of the bone tunnels between the two groups were almost the same. However, the shape of bone tunnels in the FT group was more flattened. A faster cellular and collagen remoulding process were found in the FT group. Semiquantitative histological analysis of Safranin O staining showed that there was more fibrocartilage formation in the interface region in the FT group (
P
< 0.05). Sirius Red staining showed that the tissues in the interface areas were more intense in the FT group. Micro-CT scanning showed that more new bone formation could be found in the interface region in the FT group. The biomechanical tests also showed that FT ACL reconstruction will result in a stronger regenerated tendon–bone interface.
Conclusions
Our study found that a flattened bone tunnel accelerated TBH in the early period after ACL reconstruction surgery in a rabbit model, which lays the groundwork for further clinical practice of this ACL reconstruction method.</description><subject>Animals</subject><subject>Anterior cruciate ligament</subject><subject>Anterior Cruciate Ligament - surgery</subject><subject>Anterior Cruciate Ligament Reconstruction - methods</subject><subject>Biomechanical engineering</subject><subject>Biomechanics</subject><subject>Bone and Bones - physiology</subject><subject>Bone and Bones - surgery</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Bone surgery</subject><subject>Collagen</subject><subject>Collagen - biosynthesis</subject><subject>Computed tomography</subject><subject>Fibrocartilage - physiology</subject><subject>Flattening</subject><subject>Healing</subject><subject>Knee</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Animal</subject><subject>Orthopedics</subject><subject>Osteogenesis</subject><subject>Rabbits</subject><subject>Random Allocation</subject><subject>Scanning</subject><subject>Staining</subject><subject>Tendons - physiology</subject><subject>Tendons - surgery</subject><subject>Tunnels</subject><subject>Wound Healing</subject><issn>0942-2056</issn><issn>1433-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0c1qGzEQB3BREhrH7Qv0EAS59LLJ6GNX3qMxaRsw9JKehawd2RvW0kbSlvjWd8gb9kmixCmFnGZgfgzD_An5wuCKAajrBMAaVQFrK6glh0p9IDMmhaiUkOqEzKCVvOJQN2fkPKV7gNLK9iM5E7BQSjA1I49Lug8RqRtMzuixo5vgkebJexzoziRq6BhSn_vfSNE5tJkGTwvtgv_75-lV79AMvd_Svgx2hZk4HOiIsQ8dNS5jpMvVmka0waccJ5v74D-RU2eGhJ_f6pz8-nZzt_pRrX9-v10t19XImciVctgYZK7rEBtZG7vgChDdRtUSay7MAheqYVy5VgEzaIWzXYu1sBsrBRdiTr4e944xPEyYst73yeIwGI9hSpqzVrCmlQIKvXxH78MUfbnuRTEFEmRd1MWbmjZ77PQY-72JB_3vpwWII0hl5LcY_69hoF-S08fkdElOvyanlXgGFO2K7w</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Zhao, Fengyuan</creator><creator>Hu, Xiaoqing</creator><creator>Zhang, Jiahao</creator><creator>Shi, Weili</creator><creator>Ren, Bo</creator><creator>Huang, Hongjie</creator><creator>Ao, Yingfang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8909-2022</orcidid></search><sort><creationdate>20191101</creationdate><title>A more flattened bone tunnel has a positive effect on tendon–bone healing in the early period after ACL reconstruction</title><author>Zhao, Fengyuan ; Hu, Xiaoqing ; Zhang, Jiahao ; Shi, Weili ; Ren, Bo ; Huang, Hongjie ; Ao, Yingfang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p213t-7fe6ae1fddee645ac8270eefb754e523a8e876127f9701aec3fcd9e53cbc43233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anterior cruciate ligament</topic><topic>Anterior Cruciate Ligament - surgery</topic><topic>Anterior Cruciate Ligament Reconstruction - methods</topic><topic>Biomechanical engineering</topic><topic>Biomechanics</topic><topic>Bone and Bones - physiology</topic><topic>Bone and Bones - surgery</topic><topic>Bone growth</topic><topic>Bone healing</topic><topic>Bone surgery</topic><topic>Collagen</topic><topic>Collagen - biosynthesis</topic><topic>Computed tomography</topic><topic>Fibrocartilage - physiology</topic><topic>Flattening</topic><topic>Healing</topic><topic>Knee</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Animal</topic><topic>Orthopedics</topic><topic>Osteogenesis</topic><topic>Rabbits</topic><topic>Random Allocation</topic><topic>Scanning</topic><topic>Staining</topic><topic>Tendons - physiology</topic><topic>Tendons - surgery</topic><topic>Tunnels</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Fengyuan</creatorcontrib><creatorcontrib>Hu, Xiaoqing</creatorcontrib><creatorcontrib>Zhang, Jiahao</creatorcontrib><creatorcontrib>Shi, Weili</creatorcontrib><creatorcontrib>Ren, Bo</creatorcontrib><creatorcontrib>Huang, Hongjie</creatorcontrib><creatorcontrib>Ao, Yingfang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Fengyuan</au><au>Hu, Xiaoqing</au><au>Zhang, Jiahao</au><au>Shi, Weili</au><au>Ren, Bo</au><au>Huang, Hongjie</au><au>Ao, Yingfang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A more flattened bone tunnel has a positive effect on tendon–bone healing in the early period after ACL reconstruction</atitle><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle><stitle>Knee Surg Sports Traumatol Arthrosc</stitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>27</volume><issue>11</issue><spage>3543</spage><epage>3551</epage><pages>3543-3551</pages><issn>0942-2056</issn><eissn>1433-7347</eissn><abstract>Purpose
The purpose of this study was to evaluate whether a flattened bone tunnel has a positive effect on the tendon–bone healing (TBH) process in the early period after anterior cruciate ligament (ACL) reconstruction.
Methods
Seventy-two New Zealand White rabbits were randomly allocated into two groups, the flattened tunnel (FT) group and the conventional round tunnel (RT) group. We compared the cross-sectional areas and diameters of the bone tunnels between the two groups through computed tomography (CT) scanning. TBH results between the two groups were assessed by histological analysis, micro-CT scanning and biomechanical tests at 4 weeks, 8 weeks and 12 weeks after operation.
Results
The cross-sectional areas of the bone tunnels between the two groups were almost the same. However, the shape of bone tunnels in the FT group was more flattened. A faster cellular and collagen remoulding process were found in the FT group. Semiquantitative histological analysis of Safranin O staining showed that there was more fibrocartilage formation in the interface region in the FT group (
P
< 0.05). Sirius Red staining showed that the tissues in the interface areas were more intense in the FT group. Micro-CT scanning showed that more new bone formation could be found in the interface region in the FT group. The biomechanical tests also showed that FT ACL reconstruction will result in a stronger regenerated tendon–bone interface.
Conclusions
Our study found that a flattened bone tunnel accelerated TBH in the early period after ACL reconstruction surgery in a rabbit model, which lays the groundwork for further clinical practice of this ACL reconstruction method.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30877317</pmid><doi>10.1007/s00167-019-05420-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8909-2022</orcidid></addata></record> |
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| ispartof | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019-11, Vol.27 (11), p.3543-3551 |
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| source | MEDLINE; SpringerNature Journals; Access via Wiley Online Library |
| subjects | Animals Anterior cruciate ligament Anterior Cruciate Ligament - surgery Anterior Cruciate Ligament Reconstruction - methods Biomechanical engineering Biomechanics Bone and Bones - physiology Bone and Bones - surgery Bone growth Bone healing Bone surgery Collagen Collagen - biosynthesis Computed tomography Fibrocartilage - physiology Flattening Healing Knee Male Medical imaging Medicine Medicine & Public Health Models, Animal Orthopedics Osteogenesis Rabbits Random Allocation Scanning Staining Tendons - physiology Tendons - surgery Tunnels Wound Healing |
| title | A more flattened bone tunnel has a positive effect on tendon–bone healing in the early period after ACL reconstruction |
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