Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls
Purpose Increased arterial stiffness is an early sign of endothelial dysfunction. Nevertheless, measures of the elastic properties of the aortic root in patients with type 1 diabetes are still lacking. The aim of this study was to compare aortic root stiffness index in type 1 diabetes and healthy co...
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| Veröffentlicht in: | Journal of endocrinological investigation 2019-09, Vol.42 (9), p.1109-1115 |
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| container_title | Journal of endocrinological investigation |
| container_volume | 42 |
| creator | Zoppini, G. Bergamini, C. Trombetta, M. Sabbagh, L. Dauriz, M. Mantovani, A. Targher, G. Fossà, I. Rinaldi, E. Bonora, E. |
| description | Purpose
Increased arterial stiffness is an early sign of endothelial dysfunction. Nevertheless, measures of the elastic properties of the aortic root in patients with type 1 diabetes are still lacking. The aim of this study was to compare aortic root stiffness index in type 1 diabetes and healthy controls.
Methods
Ninety-three patients with type 1 diabetes without cardiovascular diseases were recruited and compared to 33 healthy controls. Aortic root elastic properties were estimated by measuring the systolic and diastolic diameters on M-mode acquisition.
Results
None of the subjects showed alterations of either systolic or diastolic echocardiographic parameters. Patients with type 1 diabetes had a very low prevalence of chronic complications and their metabolic control was good. Significantly increased aortic stiffness index was found in type 1 diabetes compared to controls, and the same different pattern was found in men and women. The presence of type 1 diabetes and increased pulse pressure was significantly associated with aortic stiffness index in a multivariate linear analysis.
Conclusion
This study strongly suggests that patients with type 1 diabetes develop aortic root stiffness in the absence of cardiovascular diseases. This alteration may be part of a more generalized arterial dysfunction in type 1 diabetes. |
| doi_str_mv | 10.1007/s40618-019-01032-7 |
| format | Article |
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Increased arterial stiffness is an early sign of endothelial dysfunction. Nevertheless, measures of the elastic properties of the aortic root in patients with type 1 diabetes are still lacking. The aim of this study was to compare aortic root stiffness index in type 1 diabetes and healthy controls.
Methods
Ninety-three patients with type 1 diabetes without cardiovascular diseases were recruited and compared to 33 healthy controls. Aortic root elastic properties were estimated by measuring the systolic and diastolic diameters on M-mode acquisition.
Results
None of the subjects showed alterations of either systolic or diastolic echocardiographic parameters. Patients with type 1 diabetes had a very low prevalence of chronic complications and their metabolic control was good. Significantly increased aortic stiffness index was found in type 1 diabetes compared to controls, and the same different pattern was found in men and women. The presence of type 1 diabetes and increased pulse pressure was significantly associated with aortic stiffness index in a multivariate linear analysis.
Conclusion
This study strongly suggests that patients with type 1 diabetes develop aortic root stiffness in the absence of cardiovascular diseases. This alteration may be part of a more generalized arterial dysfunction in type 1 diabetes.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-019-01032-7</identifier><identifier>PMID: 30877659</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aorta ; Biomarkers - analysis ; Cardiovascular Diseases ; Case-Control Studies ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetic Cardiomyopathies ; Doppler effect ; Endocrinology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Italy - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article ; Prognosis ; Vascular Stiffness ; Ventricular Dysfunction, Left - epidemiology</subject><ispartof>Journal of endocrinological investigation, 2019-09, Vol.42 (9), p.1109-1115</ispartof><rights>Italian Society of Endocrinology (SIE) 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-f450c9329dfd09bc0862e51debdd0762f28ef159d0e8739adb3f0411f717d2c3</citedby><cites>FETCH-LOGICAL-c375t-f450c9329dfd09bc0862e51debdd0762f28ef159d0e8739adb3f0411f717d2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-019-01032-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-019-01032-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30877659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zoppini, G.</creatorcontrib><creatorcontrib>Bergamini, C.</creatorcontrib><creatorcontrib>Trombetta, M.</creatorcontrib><creatorcontrib>Sabbagh, L.</creatorcontrib><creatorcontrib>Dauriz, M.</creatorcontrib><creatorcontrib>Mantovani, A.</creatorcontrib><creatorcontrib>Targher, G.</creatorcontrib><creatorcontrib>Fossà, I.</creatorcontrib><creatorcontrib>Rinaldi, E.</creatorcontrib><creatorcontrib>Bonora, E.</creatorcontrib><title>Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
Increased arterial stiffness is an early sign of endothelial dysfunction. Nevertheless, measures of the elastic properties of the aortic root in patients with type 1 diabetes are still lacking. The aim of this study was to compare aortic root stiffness index in type 1 diabetes and healthy controls.
Methods
Ninety-three patients with type 1 diabetes without cardiovascular diseases were recruited and compared to 33 healthy controls. Aortic root elastic properties were estimated by measuring the systolic and diastolic diameters on M-mode acquisition.
Results
None of the subjects showed alterations of either systolic or diastolic echocardiographic parameters. Patients with type 1 diabetes had a very low prevalence of chronic complications and their metabolic control was good. Significantly increased aortic stiffness index was found in type 1 diabetes compared to controls, and the same different pattern was found in men and women. The presence of type 1 diabetes and increased pulse pressure was significantly associated with aortic stiffness index in a multivariate linear analysis.
Conclusion
This study strongly suggests that patients with type 1 diabetes develop aortic root stiffness in the absence of cardiovascular diseases. This alteration may be part of a more generalized arterial dysfunction in type 1 diabetes.</description><subject>Adult</subject><subject>Aorta</subject><subject>Biomarkers - analysis</subject><subject>Cardiovascular Diseases</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetic Cardiomyopathies</subject><subject>Doppler effect</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Vascular Stiffness</subject><subject>Ventricular Dysfunction, Left - epidemiology</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1O3TAQha2qqNBbXqCLylI3bAL-uYnjZYWAIiF1w95y7DE1yo2Dx6Hl7fFtoK266MKe0cyZb0Y6hHzk7JQzps5wyzreN4zr-pgUjXpDjrgSrOll3739Kz8k7xHvGZNK9uodOZSsV6pr9RFZrieXwSJ4alMu0VEsMYQJEGmcPPysP51tiTAVpD9i-U7L0wyUUx_tAAXWYloKdTb7mB4tumW0ufZxz6Uu7WabK7-kmk8lpxE_kINgR4Tjl7ght5cXt-dfm5tvV9fnX24aJ1VbmrBtmdNSaB8804NjfSeg5R4G75nqRBA9BN5qz6BXUls_yMC2nAfFlRdObsjJip1zelgAi9lFdDCOdoK0oBFcS97pfdiQz_9I79OSp3qcEUIJ1XHdtVUlVpXLCTFDMHOOO5ufDGdm74lZPTHVE_PLE6Pq0KcX9DLswP8eeTWhCuQqwNqa7iD_2f0f7DP51Zjr</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Zoppini, G.</creator><creator>Bergamini, C.</creator><creator>Trombetta, M.</creator><creator>Sabbagh, L.</creator><creator>Dauriz, M.</creator><creator>Mantovani, A.</creator><creator>Targher, G.</creator><creator>Fossà, I.</creator><creator>Rinaldi, E.</creator><creator>Bonora, E.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls</title><author>Zoppini, G. ; Bergamini, C. ; Trombetta, M. ; Sabbagh, L. ; Dauriz, M. ; Mantovani, A. ; Targher, G. ; Fossà, I. ; Rinaldi, E. ; Bonora, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-f450c9329dfd09bc0862e51debdd0762f28ef159d0e8739adb3f0411f717d2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aorta</topic><topic>Biomarkers - analysis</topic><topic>Cardiovascular Diseases</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetic Cardiomyopathies</topic><topic>Doppler effect</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Vascular Stiffness</topic><topic>Ventricular Dysfunction, Left - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zoppini, G.</creatorcontrib><creatorcontrib>Bergamini, C.</creatorcontrib><creatorcontrib>Trombetta, M.</creatorcontrib><creatorcontrib>Sabbagh, L.</creatorcontrib><creatorcontrib>Dauriz, M.</creatorcontrib><creatorcontrib>Mantovani, A.</creatorcontrib><creatorcontrib>Targher, G.</creatorcontrib><creatorcontrib>Fossà, I.</creatorcontrib><creatorcontrib>Rinaldi, E.</creatorcontrib><creatorcontrib>Bonora, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zoppini, G.</au><au>Bergamini, C.</au><au>Trombetta, M.</au><au>Sabbagh, L.</au><au>Dauriz, M.</au><au>Mantovani, A.</au><au>Targher, G.</au><au>Fossà, I.</au><au>Rinaldi, E.</au><au>Bonora, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>42</volume><issue>9</issue><spage>1109</spage><epage>1115</epage><pages>1109-1115</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
Increased arterial stiffness is an early sign of endothelial dysfunction. Nevertheless, measures of the elastic properties of the aortic root in patients with type 1 diabetes are still lacking. The aim of this study was to compare aortic root stiffness index in type 1 diabetes and healthy controls.
Methods
Ninety-three patients with type 1 diabetes without cardiovascular diseases were recruited and compared to 33 healthy controls. Aortic root elastic properties were estimated by measuring the systolic and diastolic diameters on M-mode acquisition.
Results
None of the subjects showed alterations of either systolic or diastolic echocardiographic parameters. Patients with type 1 diabetes had a very low prevalence of chronic complications and their metabolic control was good. Significantly increased aortic stiffness index was found in type 1 diabetes compared to controls, and the same different pattern was found in men and women. The presence of type 1 diabetes and increased pulse pressure was significantly associated with aortic stiffness index in a multivariate linear analysis.
Conclusion
This study strongly suggests that patients with type 1 diabetes develop aortic root stiffness in the absence of cardiovascular diseases. This alteration may be part of a more generalized arterial dysfunction in type 1 diabetes.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30877659</pmid><doi>10.1007/s40618-019-01032-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of endocrinological investigation, 2019-09, Vol.42 (9), p.1109-1115 |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Adult Aorta Biomarkers - analysis Cardiovascular Diseases Case-Control Studies Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - physiopathology Diabetic Cardiomyopathies Doppler effect Endocrinology Female Follow-Up Studies Humans Incidence Italy - epidemiology Male Medicine Medicine & Public Health Metabolic Diseases Original Article Prognosis Vascular Stiffness Ventricular Dysfunction, Left - epidemiology |
| title | Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls |
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