Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells
Linoleic acid (LA) is an essential and omega-6 polyunsaturated fatty acid that mediates a variety of biological processes, including migration and invasion in breast cancer cells. Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Increase...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2019-07, Vol.457 (1-2), p.119-132 |
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| creator | Diaz-Aragon, Ricardo Ramirez-Ricardo, Javier Cortes-Reynosa, Pedro Simoni-Nieves, Arturo Gomez-Quiroz, Luis-Enrique Perez Salazar, Eduardo |
| description | Linoleic acid (LA) is an essential and omega-6 polyunsaturated fatty acid that mediates a variety of biological processes, including migration and invasion in breast cancer cells. Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Increases of expression and activity of PLD are reported in several human cancers, including gastric, colorectal, renal, stomach, lung and breast. In this article, we demonstrate that LA induces an increase of PLD activity in MDA-MB-231 breast cancer cells. Particularly, PLD1 and/or PLD2 mediate migration and invasion induced by LA. Moreover, LA induces increases in number and size of spheroids via PLD activity. FFAR1 also mediates migration and invasion, whereas PLD activation induced by LA requires the activities of FFAR1, FFAR4 and EGFR in MDA-MB-231 cells. In summary, PLD plays a pivotal role in migration and invasion induced by LA in MDA-MB-231 breast cancer cells. |
| doi_str_mv | 10.1007/s11010-019-03517-8 |
| format | Article |
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Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Increases of expression and activity of PLD are reported in several human cancers, including gastric, colorectal, renal, stomach, lung and breast. In this article, we demonstrate that LA induces an increase of PLD activity in MDA-MB-231 breast cancer cells. Particularly, PLD1 and/or PLD2 mediate migration and invasion induced by LA. Moreover, LA induces increases in number and size of spheroids via PLD activity. FFAR1 also mediates migration and invasion, whereas PLD activation induced by LA requires the activities of FFAR1, FFAR4 and EGFR in MDA-MB-231 cells. In summary, PLD plays a pivotal role in migration and invasion induced by LA in MDA-MB-231 breast cancer cells.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-019-03517-8</identifier><identifier>PMID: 30877512</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biological activity ; Biomedical and Life Sciences ; Breast cancer ; Cancer ; Cancer cells ; Cardiology ; Choline ; Epidermal growth factor receptors ; Lecithin ; Life Sciences ; Linoleic acid ; Linoleic acids ; Lungs ; Medical Biochemistry ; Oncology ; Phosphatidic acid ; Phosphatidylcholine ; Phospholipase ; Phospholipase D ; Phospholipases ; Polyunsaturated fatty acids ; Spheroids ; Stomach ; Unsaturated fatty acids</subject><ispartof>Molecular and cellular biochemistry, 2019-07, Vol.457 (1-2), p.119-132</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Molecular and Cellular Biochemistry is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-97db66455a00225514e6a2c4c1976165956f819bbf0b1418583d15413dbd0b043</citedby><cites>FETCH-LOGICAL-c442t-97db66455a00225514e6a2c4c1976165956f819bbf0b1418583d15413dbd0b043</cites><orcidid>0000-0002-3041-7902</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-019-03517-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-019-03517-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30877512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diaz-Aragon, Ricardo</creatorcontrib><creatorcontrib>Ramirez-Ricardo, Javier</creatorcontrib><creatorcontrib>Cortes-Reynosa, Pedro</creatorcontrib><creatorcontrib>Simoni-Nieves, Arturo</creatorcontrib><creatorcontrib>Gomez-Quiroz, Luis-Enrique</creatorcontrib><creatorcontrib>Perez Salazar, Eduardo</creatorcontrib><title>Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Linoleic acid (LA) is an essential and omega-6 polyunsaturated fatty acid that mediates a variety of biological processes, including migration and invasion in breast cancer cells. Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Increases of expression and activity of PLD are reported in several human cancers, including gastric, colorectal, renal, stomach, lung and breast. In this article, we demonstrate that LA induces an increase of PLD activity in MDA-MB-231 breast cancer cells. Particularly, PLD1 and/or PLD2 mediate migration and invasion induced by LA. Moreover, LA induces increases in number and size of spheroids via PLD activity. FFAR1 also mediates migration and invasion, whereas PLD activation induced by LA requires the activities of FFAR1, FFAR4 and EGFR in MDA-MB-231 cells. 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| subjects | Biochemistry Biological activity Biomedical and Life Sciences Breast cancer Cancer Cancer cells Cardiology Choline Epidermal growth factor receptors Lecithin Life Sciences Linoleic acid Linoleic acids Lungs Medical Biochemistry Oncology Phosphatidic acid Phosphatidylcholine Phospholipase Phospholipase D Phospholipases Polyunsaturated fatty acids Spheroids Stomach Unsaturated fatty acids |
| title | Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells |
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