Neutrophil‐to‐lymphocyte ratio as indicator to severe complication after pancreaticoduodenectomy or distal pancreatectomy
Background Pancreaticoduodenectomy and distal pancreatectomy are complex procedures with high rates of post‐operative complications. We evaluated the factors associated with post‐operative complications, focusing on pre‐operative hematologic markers such as the neutrophil‐to‐lymphocyte ratio, platel...
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| Veröffentlicht in: | Acta anaesthesiologica Scandinavica 2019-07, Vol.63 (6), p.739-744 |
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| creator | Ida, Mitsuru Tachiiri, Yuka Sato, Mariko Kawaguchi, Masahiko |
| description | Background
Pancreaticoduodenectomy and distal pancreatectomy are complex procedures with high rates of post‐operative complications. We evaluated the factors associated with post‐operative complications, focusing on pre‐operative hematologic markers such as the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index.
Methods
Data from patients (≥age 20) who underwent pancreaticoduodenectomy or distal pancreatectomy between January 2013 and December 2017 at a Japanese tertiary hospital were retrospectively reviewed. Patients who failed to complete the operation and those who underwent additional procedure were excluded. The primary outcome was reoperation and unplanned intensive care unit admission before first discharge, and secondary outcome was the length of hospital stay. Multivariate analysis was used to identify explanatory factors associated with post‐operative complications. The differences in length of hospital stay were compared with the Mann‐Whitney U test.
Results
Of 238 eligible patients, 208 with a median age of 71 years were included in the analysis. The median values [1st interquartile range, 3rd interquartile range] of the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index were 2.65 [1.69, 4.04], 247 [146, 407], and 46.0 [42.0, 49.7], respectively. Eleven patients (5.3%) experienced post‐operative complications. The neutrophil‐to‐lymphocyte ratio (odds ratio, 1.13; 95% confidence interval, 1.02‐1.26; P = 0.03) and blood loss volume (odds ratio per 100 mL, 1.11; 95% confidence interval, 1.00‐1.22; P = 0.039) were independently associated with post‐operative complications. Post‐operative complications contributed to longer hospital stays (19 [15, 28] vs 33 [22, 65] days, P = 0.005).
Conclusion
The neutrophil‐to‐lymphocyte ratio and blood loss volume were significantly associated with post‐operative complications, leading to prolonged hospitalization. |
| doi_str_mv | 10.1111/aas.13341 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2193167768</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2193167768</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4191-a0cbdb2e798815bc21ec895e079c47e9ad5a4cd668c0164b44cb264063b91ca3</originalsourceid><addsrcrecordid>eNp1kctq3TAQhkVpaE4ui75AEXTTLJxI1s1aHkLbBEK6aPZClucQBdtyJbnFi0Ifoc_YJ6kSJ1kEMosZZuabn4EfofeUnNISZ9amU8oYp2_QhjKtKymUfIs2hBBaCarqfXSQ0l1pGdf6HdpnpFGcEbVBv69hzjFMt77_9-dvDiX1yzDdBrdkwNFmH7BN2I-ddzaHiHPACX5CBOzCMPX3Ux9GbHcZIp7s6CKUiQvdHDoYweUwLLjcdT5l2z8T6-II7e1sn-D4sR6imy-fb84vqqtvXy_Pt1eV41TTyhLXdm0NSjcNFa2rKbhGCyBKO65A205Y7jopG0eo5C3nrq0lJ5K1mjrLDtGnVXaK4ccMKZvBJwd9b0cIczI11YxKpWRT0I8v0Lswx7E8Z-qaCaEErUWhTlbKxZBShJ2Zoh9sXAwl5t4SUywxD5YU9sOj4twO0D2TTx4U4GwFfvkelteVzHb7fZX8D8-nmiE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2235575125</pqid></control><display><type>article</type><title>Neutrophil‐to‐lymphocyte ratio as indicator to severe complication after pancreaticoduodenectomy or distal pancreatectomy</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ida, Mitsuru ; Tachiiri, Yuka ; Sato, Mariko ; Kawaguchi, Masahiko</creator><creatorcontrib>Ida, Mitsuru ; Tachiiri, Yuka ; Sato, Mariko ; Kawaguchi, Masahiko</creatorcontrib><description>Background
Pancreaticoduodenectomy and distal pancreatectomy are complex procedures with high rates of post‐operative complications. We evaluated the factors associated with post‐operative complications, focusing on pre‐operative hematologic markers such as the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index.
Methods
Data from patients (≥age 20) who underwent pancreaticoduodenectomy or distal pancreatectomy between January 2013 and December 2017 at a Japanese tertiary hospital were retrospectively reviewed. Patients who failed to complete the operation and those who underwent additional procedure were excluded. The primary outcome was reoperation and unplanned intensive care unit admission before first discharge, and secondary outcome was the length of hospital stay. Multivariate analysis was used to identify explanatory factors associated with post‐operative complications. The differences in length of hospital stay were compared with the Mann‐Whitney U test.
Results
Of 238 eligible patients, 208 with a median age of 71 years were included in the analysis. The median values [1st interquartile range, 3rd interquartile range] of the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index were 2.65 [1.69, 4.04], 247 [146, 407], and 46.0 [42.0, 49.7], respectively. Eleven patients (5.3%) experienced post‐operative complications. The neutrophil‐to‐lymphocyte ratio (odds ratio, 1.13; 95% confidence interval, 1.02‐1.26; P = 0.03) and blood loss volume (odds ratio per 100 mL, 1.11; 95% confidence interval, 1.00‐1.22; P = 0.039) were independently associated with post‐operative complications. Post‐operative complications contributed to longer hospital stays (19 [15, 28] vs 33 [22, 65] days, P = 0.005).
Conclusion
The neutrophil‐to‐lymphocyte ratio and blood loss volume were significantly associated with post‐operative complications, leading to prolonged hospitalization.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1111/aas.13341</identifier><identifier>PMID: 30874307</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Blood ; Complications ; Confidence intervals ; Lymphocytes ; Multivariate analysis ; Neutrophils ; Pancreaticoduodenectomy ; Platelets</subject><ispartof>Acta anaesthesiologica Scandinavica, 2019-07, Vol.63 (6), p.739-744</ispartof><rights>2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 The Acta Anaesthesiologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4191-a0cbdb2e798815bc21ec895e079c47e9ad5a4cd668c0164b44cb264063b91ca3</citedby><cites>FETCH-LOGICAL-c4191-a0cbdb2e798815bc21ec895e079c47e9ad5a4cd668c0164b44cb264063b91ca3</cites><orcidid>0000-0001-5285-257X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faas.13341$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faas.13341$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30874307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ida, Mitsuru</creatorcontrib><creatorcontrib>Tachiiri, Yuka</creatorcontrib><creatorcontrib>Sato, Mariko</creatorcontrib><creatorcontrib>Kawaguchi, Masahiko</creatorcontrib><title>Neutrophil‐to‐lymphocyte ratio as indicator to severe complication after pancreaticoduodenectomy or distal pancreatectomy</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Background
Pancreaticoduodenectomy and distal pancreatectomy are complex procedures with high rates of post‐operative complications. We evaluated the factors associated with post‐operative complications, focusing on pre‐operative hematologic markers such as the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index.
Methods
Data from patients (≥age 20) who underwent pancreaticoduodenectomy or distal pancreatectomy between January 2013 and December 2017 at a Japanese tertiary hospital were retrospectively reviewed. Patients who failed to complete the operation and those who underwent additional procedure were excluded. The primary outcome was reoperation and unplanned intensive care unit admission before first discharge, and secondary outcome was the length of hospital stay. Multivariate analysis was used to identify explanatory factors associated with post‐operative complications. The differences in length of hospital stay were compared with the Mann‐Whitney U test.
Results
Of 238 eligible patients, 208 with a median age of 71 years were included in the analysis. The median values [1st interquartile range, 3rd interquartile range] of the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index were 2.65 [1.69, 4.04], 247 [146, 407], and 46.0 [42.0, 49.7], respectively. Eleven patients (5.3%) experienced post‐operative complications. The neutrophil‐to‐lymphocyte ratio (odds ratio, 1.13; 95% confidence interval, 1.02‐1.26; P = 0.03) and blood loss volume (odds ratio per 100 mL, 1.11; 95% confidence interval, 1.00‐1.22; P = 0.039) were independently associated with post‐operative complications. Post‐operative complications contributed to longer hospital stays (19 [15, 28] vs 33 [22, 65] days, P = 0.005).
Conclusion
The neutrophil‐to‐lymphocyte ratio and blood loss volume were significantly associated with post‐operative complications, leading to prolonged hospitalization.</description><subject>Blood</subject><subject>Complications</subject><subject>Confidence intervals</subject><subject>Lymphocytes</subject><subject>Multivariate analysis</subject><subject>Neutrophils</subject><subject>Pancreaticoduodenectomy</subject><subject>Platelets</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kctq3TAQhkVpaE4ui75AEXTTLJxI1s1aHkLbBEK6aPZClucQBdtyJbnFi0Ifoc_YJ6kSJ1kEMosZZuabn4EfofeUnNISZ9amU8oYp2_QhjKtKymUfIs2hBBaCarqfXSQ0l1pGdf6HdpnpFGcEbVBv69hzjFMt77_9-dvDiX1yzDdBrdkwNFmH7BN2I-ddzaHiHPACX5CBOzCMPX3Ux9GbHcZIp7s6CKUiQvdHDoYweUwLLjcdT5l2z8T6-II7e1sn-D4sR6imy-fb84vqqtvXy_Pt1eV41TTyhLXdm0NSjcNFa2rKbhGCyBKO65A205Y7jopG0eo5C3nrq0lJ5K1mjrLDtGnVXaK4ccMKZvBJwd9b0cIczI11YxKpWRT0I8v0Lswx7E8Z-qaCaEErUWhTlbKxZBShJ2Zoh9sXAwl5t4SUywxD5YU9sOj4twO0D2TTx4U4GwFfvkelteVzHb7fZX8D8-nmiE</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Ida, Mitsuru</creator><creator>Tachiiri, Yuka</creator><creator>Sato, Mariko</creator><creator>Kawaguchi, Masahiko</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5285-257X</orcidid></search><sort><creationdate>201907</creationdate><title>Neutrophil‐to‐lymphocyte ratio as indicator to severe complication after pancreaticoduodenectomy or distal pancreatectomy</title><author>Ida, Mitsuru ; Tachiiri, Yuka ; Sato, Mariko ; Kawaguchi, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4191-a0cbdb2e798815bc21ec895e079c47e9ad5a4cd668c0164b44cb264063b91ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Blood</topic><topic>Complications</topic><topic>Confidence intervals</topic><topic>Lymphocytes</topic><topic>Multivariate analysis</topic><topic>Neutrophils</topic><topic>Pancreaticoduodenectomy</topic><topic>Platelets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ida, Mitsuru</creatorcontrib><creatorcontrib>Tachiiri, Yuka</creatorcontrib><creatorcontrib>Sato, Mariko</creatorcontrib><creatorcontrib>Kawaguchi, Masahiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ida, Mitsuru</au><au>Tachiiri, Yuka</au><au>Sato, Mariko</au><au>Kawaguchi, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil‐to‐lymphocyte ratio as indicator to severe complication after pancreaticoduodenectomy or distal pancreatectomy</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2019-07</date><risdate>2019</risdate><volume>63</volume><issue>6</issue><spage>739</spage><epage>744</epage><pages>739-744</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><abstract>Background
Pancreaticoduodenectomy and distal pancreatectomy are complex procedures with high rates of post‐operative complications. We evaluated the factors associated with post‐operative complications, focusing on pre‐operative hematologic markers such as the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index.
Methods
Data from patients (≥age 20) who underwent pancreaticoduodenectomy or distal pancreatectomy between January 2013 and December 2017 at a Japanese tertiary hospital were retrospectively reviewed. Patients who failed to complete the operation and those who underwent additional procedure were excluded. The primary outcome was reoperation and unplanned intensive care unit admission before first discharge, and secondary outcome was the length of hospital stay. Multivariate analysis was used to identify explanatory factors associated with post‐operative complications. The differences in length of hospital stay were compared with the Mann‐Whitney U test.
Results
Of 238 eligible patients, 208 with a median age of 71 years were included in the analysis. The median values [1st interquartile range, 3rd interquartile range] of the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and prognostic nutritional index were 2.65 [1.69, 4.04], 247 [146, 407], and 46.0 [42.0, 49.7], respectively. Eleven patients (5.3%) experienced post‐operative complications. The neutrophil‐to‐lymphocyte ratio (odds ratio, 1.13; 95% confidence interval, 1.02‐1.26; P = 0.03) and blood loss volume (odds ratio per 100 mL, 1.11; 95% confidence interval, 1.00‐1.22; P = 0.039) were independently associated with post‐operative complications. Post‐operative complications contributed to longer hospital stays (19 [15, 28] vs 33 [22, 65] days, P = 0.005).
Conclusion
The neutrophil‐to‐lymphocyte ratio and blood loss volume were significantly associated with post‐operative complications, leading to prolonged hospitalization.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30874307</pmid><doi>10.1111/aas.13341</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5285-257X</orcidid></addata></record> |
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| ispartof | Acta anaesthesiologica Scandinavica, 2019-07, Vol.63 (6), p.739-744 |
| issn | 0001-5172 1399-6576 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Blood Complications Confidence intervals Lymphocytes Multivariate analysis Neutrophils Pancreaticoduodenectomy Platelets |
| title | Neutrophil‐to‐lymphocyte ratio as indicator to severe complication after pancreaticoduodenectomy or distal pancreatectomy |
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