Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females
Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have b...
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Veröffentlicht in: | Behavioral neuroscience 2019-08, Vol.133 (4), p.378-384 |
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description | Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males. |
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Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/bne0000313</identifier><identifier>PMID: 30869949</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Animal ; Animal Sex Differences ; Animal Sexual Behavior ; Animal Sexual Receptivity ; Animals ; Behavior ; Behavioral plasticity ; Brain - physiology ; Copulation - physiology ; Cricetinae ; Dopamine ; Drug abuse ; Female ; Females ; FosB protein ; Hamsters ; Male ; Males ; Mesocricetus - metabolism ; Mesolimbic system ; Molecular modelling ; Motivation ; Motivation - physiology ; Neural Plasticity ; Neuronal Plasticity - physiology ; Nucleus Accumbens ; Nucleus Accumbens - physiology ; Proteins ; Proto-Oncogene Proteins c-fos - metabolism ; Proto-Oncogene Proteins c-fos - physiology ; Reinforcement ; Reward ; Rewards ; Rodents ; Sex ; Sex Factors ; Sexual Behavior, Animal - physiology ; Transcription Factors ; Western blotting</subject><ispartof>Behavioral neuroscience, 2019-08, Vol.133 (4), p.378-384</ispartof><rights>2019 American Psychological Association</rights><rights>2019, American Psychological Association</rights><rights>Copyright American Psychological Association Aug 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a380t-4b498762eee9661d69bea9581b80728839ce0b8f40a70c00e53e11d8f0a11fe53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30869949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Burwell, Rebecca D</contributor><creatorcontrib>Acaba, Luis</creatorcontrib><creatorcontrib>Sidibe, David</creatorcontrib><creatorcontrib>Thygesen, John</creatorcontrib><creatorcontrib>Van der Kloot, Harrison</creatorcontrib><creatorcontrib>Been, Laura E</creatorcontrib><title>Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males.</description><subject>Animal</subject><subject>Animal Sex Differences</subject><subject>Animal Sexual Behavior</subject><subject>Animal Sexual Receptivity</subject><subject>Animals</subject><subject>Behavior</subject><subject>Behavioral plasticity</subject><subject>Brain - physiology</subject><subject>Copulation - physiology</subject><subject>Cricetinae</subject><subject>Dopamine</subject><subject>Drug abuse</subject><subject>Female</subject><subject>Females</subject><subject>FosB protein</subject><subject>Hamsters</subject><subject>Male</subject><subject>Males</subject><subject>Mesocricetus - metabolism</subject><subject>Mesolimbic system</subject><subject>Molecular modelling</subject><subject>Motivation</subject><subject>Motivation - physiology</subject><subject>Neural Plasticity</subject><subject>Neuronal Plasticity - physiology</subject><subject>Nucleus Accumbens</subject><subject>Nucleus Accumbens - physiology</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Proto-Oncogene Proteins c-fos - physiology</subject><subject>Reinforcement</subject><subject>Reward</subject><subject>Rewards</subject><subject>Rodents</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Transcription Factors</subject><subject>Western blotting</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi1ERZfChQdAlrgg1JRx7MT2kZYurdSqB-BsTbwTkSpxgp2g7tvX0RaQOOCLben7P43mZ-yNgDMBUn9sAkE-UshnbCOstAWAUc_ZBrSsCg1KHbOXKd1nRoGqXrBjCaa2VtkNG77SA798mCh2FDzx6-AjYaLEP1M_I9-O6Zx3gd9iTxzDjm9pWJ9XOKSZYjrlzTLzLfqu72acc24VntMP_NWNkd-Ffr_GD6n0ih212Cd6_XSfsO_by28XV8XN3Zfri083BUoDc6EaZY2uSyKydS12tW0IbWVEY0CXxkjrCRrTKkANHoAqSULsTAsoRJt_J-z9wTvF8edCaXZDlzz1PQYal-TKvCVRa61MRt_9g96PSwx5OleWWkkFZfl_StgSKmkqm6kPB8rHMaVIrZtiN2DcOwFurcr9rSrDb5-USzPQ7g_6u5sMnB4AnNBNae8xzp3PW_RLjBTmVeayyCkntZGPjr2bRg</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Acaba, Luis</creator><creator>Sidibe, David</creator><creator>Thygesen, John</creator><creator>Van der Kloot, Harrison</creator><creator>Been, Laura E</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females</title><author>Acaba, Luis ; Sidibe, David ; Thygesen, John ; Van der Kloot, Harrison ; Been, Laura E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a380t-4b498762eee9661d69bea9581b80728839ce0b8f40a70c00e53e11d8f0a11fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal</topic><topic>Animal Sex Differences</topic><topic>Animal Sexual Behavior</topic><topic>Animal Sexual Receptivity</topic><topic>Animals</topic><topic>Behavior</topic><topic>Behavioral plasticity</topic><topic>Brain - physiology</topic><topic>Copulation - physiology</topic><topic>Cricetinae</topic><topic>Dopamine</topic><topic>Drug abuse</topic><topic>Female</topic><topic>Females</topic><topic>FosB protein</topic><topic>Hamsters</topic><topic>Male</topic><topic>Males</topic><topic>Mesocricetus - metabolism</topic><topic>Mesolimbic system</topic><topic>Molecular modelling</topic><topic>Motivation</topic><topic>Motivation - physiology</topic><topic>Neural Plasticity</topic><topic>Neuronal Plasticity - physiology</topic><topic>Nucleus Accumbens</topic><topic>Nucleus Accumbens - physiology</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Proto-Oncogene Proteins c-fos - physiology</topic><topic>Reinforcement</topic><topic>Reward</topic><topic>Rewards</topic><topic>Rodents</topic><topic>Sex</topic><topic>Sex Factors</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Transcription Factors</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acaba, Luis</creatorcontrib><creatorcontrib>Sidibe, David</creatorcontrib><creatorcontrib>Thygesen, John</creatorcontrib><creatorcontrib>Van der Kloot, Harrison</creatorcontrib><creatorcontrib>Been, Laura E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acaba, Luis</au><au>Sidibe, David</au><au>Thygesen, John</au><au>Van der Kloot, Harrison</au><au>Been, Laura E</au><au>Burwell, Rebecca D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2019-08</date><risdate>2019</risdate><volume>133</volume><issue>4</issue><spage>378</spage><epage>384</epage><pages>378-384</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><abstract>Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>30869949</pmid><doi>10.1037/bne0000313</doi><tpages>7</tpages></addata></record> |
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subjects | Animal Animal Sex Differences Animal Sexual Behavior Animal Sexual Receptivity Animals Behavior Behavioral plasticity Brain - physiology Copulation - physiology Cricetinae Dopamine Drug abuse Female Females FosB protein Hamsters Male Males Mesocricetus - metabolism Mesolimbic system Molecular modelling Motivation Motivation - physiology Neural Plasticity Neuronal Plasticity - physiology Nucleus Accumbens Nucleus Accumbens - physiology Proteins Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-fos - physiology Reinforcement Reward Rewards Rodents Sex Sex Factors Sexual Behavior, Animal - physiology Transcription Factors Western blotting |
title | Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females |
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