Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females

Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have b...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Behavioral neuroscience 2019-08, Vol.133 (4), p.378-384
Hauptverfasser: Acaba, Luis, Sidibe, David, Thygesen, John, Van der Kloot, Harrison, Been, Laura E
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 384
container_issue 4
container_start_page 378
container_title Behavioral neuroscience
container_volume 133
creator Acaba, Luis
Sidibe, David
Thygesen, John
Van der Kloot, Harrison
Been, Laura E
description Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males.
doi_str_mv 10.1037/bne0000313
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2193167748</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2192053859</sourcerecordid><originalsourceid>FETCH-LOGICAL-a380t-4b498762eee9661d69bea9581b80728839ce0b8f40a70c00e53e11d8f0a11fe53</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi1ERZfChQdAlrgg1JRx7MT2kZYurdSqB-BsTbwTkSpxgp2g7tvX0RaQOOCLben7P43mZ-yNgDMBUn9sAkE-UshnbCOstAWAUc_ZBrSsCg1KHbOXKd1nRoGqXrBjCaa2VtkNG77SA798mCh2FDzx6-AjYaLEP1M_I9-O6Zx3gd9iTxzDjm9pWJ9XOKSZYjrlzTLzLfqu72acc24VntMP_NWNkd-Ffr_GD6n0ih212Cd6_XSfsO_by28XV8XN3Zfri083BUoDc6EaZY2uSyKydS12tW0IbWVEY0CXxkjrCRrTKkANHoAqSULsTAsoRJt_J-z9wTvF8edCaXZDlzz1PQYal-TKvCVRa61MRt_9g96PSwx5OleWWkkFZfl_StgSKmkqm6kPB8rHMaVIrZtiN2DcOwFurcr9rSrDb5-USzPQ7g_6u5sMnB4AnNBNae8xzp3PW_RLjBTmVeayyCkntZGPjr2bRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2192053859</pqid></control><display><type>article</type><title>Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females</title><source>MEDLINE</source><source>EBSCOhost APA PsycARTICLES</source><creator>Acaba, Luis ; Sidibe, David ; Thygesen, John ; Van der Kloot, Harrison ; Been, Laura E</creator><contributor>Burwell, Rebecca D</contributor><creatorcontrib>Acaba, Luis ; Sidibe, David ; Thygesen, John ; Van der Kloot, Harrison ; Been, Laura E ; Burwell, Rebecca D</creatorcontrib><description>Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/bne0000313</identifier><identifier>PMID: 30869949</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Animal ; Animal Sex Differences ; Animal Sexual Behavior ; Animal Sexual Receptivity ; Animals ; Behavior ; Behavioral plasticity ; Brain - physiology ; Copulation - physiology ; Cricetinae ; Dopamine ; Drug abuse ; Female ; Females ; FosB protein ; Hamsters ; Male ; Males ; Mesocricetus - metabolism ; Mesolimbic system ; Molecular modelling ; Motivation ; Motivation - physiology ; Neural Plasticity ; Neuronal Plasticity - physiology ; Nucleus Accumbens ; Nucleus Accumbens - physiology ; Proteins ; Proto-Oncogene Proteins c-fos - metabolism ; Proto-Oncogene Proteins c-fos - physiology ; Reinforcement ; Reward ; Rewards ; Rodents ; Sex ; Sex Factors ; Sexual Behavior, Animal - physiology ; Transcription Factors ; Western blotting</subject><ispartof>Behavioral neuroscience, 2019-08, Vol.133 (4), p.378-384</ispartof><rights>2019 American Psychological Association</rights><rights>2019, American Psychological Association</rights><rights>Copyright American Psychological Association Aug 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a380t-4b498762eee9661d69bea9581b80728839ce0b8f40a70c00e53e11d8f0a11fe53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30869949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Burwell, Rebecca D</contributor><creatorcontrib>Acaba, Luis</creatorcontrib><creatorcontrib>Sidibe, David</creatorcontrib><creatorcontrib>Thygesen, John</creatorcontrib><creatorcontrib>Van der Kloot, Harrison</creatorcontrib><creatorcontrib>Been, Laura E</creatorcontrib><title>Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males.</description><subject>Animal</subject><subject>Animal Sex Differences</subject><subject>Animal Sexual Behavior</subject><subject>Animal Sexual Receptivity</subject><subject>Animals</subject><subject>Behavior</subject><subject>Behavioral plasticity</subject><subject>Brain - physiology</subject><subject>Copulation - physiology</subject><subject>Cricetinae</subject><subject>Dopamine</subject><subject>Drug abuse</subject><subject>Female</subject><subject>Females</subject><subject>FosB protein</subject><subject>Hamsters</subject><subject>Male</subject><subject>Males</subject><subject>Mesocricetus - metabolism</subject><subject>Mesolimbic system</subject><subject>Molecular modelling</subject><subject>Motivation</subject><subject>Motivation - physiology</subject><subject>Neural Plasticity</subject><subject>Neuronal Plasticity - physiology</subject><subject>Nucleus Accumbens</subject><subject>Nucleus Accumbens - physiology</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Proto-Oncogene Proteins c-fos - physiology</subject><subject>Reinforcement</subject><subject>Reward</subject><subject>Rewards</subject><subject>Rodents</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Transcription Factors</subject><subject>Western blotting</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi1ERZfChQdAlrgg1JRx7MT2kZYurdSqB-BsTbwTkSpxgp2g7tvX0RaQOOCLben7P43mZ-yNgDMBUn9sAkE-UshnbCOstAWAUc_ZBrSsCg1KHbOXKd1nRoGqXrBjCaa2VtkNG77SA798mCh2FDzx6-AjYaLEP1M_I9-O6Zx3gd9iTxzDjm9pWJ9XOKSZYjrlzTLzLfqu72acc24VntMP_NWNkd-Ffr_GD6n0ih212Cd6_XSfsO_by28XV8XN3Zfri083BUoDc6EaZY2uSyKydS12tW0IbWVEY0CXxkjrCRrTKkANHoAqSULsTAsoRJt_J-z9wTvF8edCaXZDlzz1PQYal-TKvCVRa61MRt_9g96PSwx5OleWWkkFZfl_StgSKmkqm6kPB8rHMaVIrZtiN2DcOwFurcr9rSrDb5-USzPQ7g_6u5sMnB4AnNBNae8xzp3PW_RLjBTmVeayyCkntZGPjr2bRg</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Acaba, Luis</creator><creator>Sidibe, David</creator><creator>Thygesen, John</creator><creator>Van der Kloot, Harrison</creator><creator>Been, Laura E</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females</title><author>Acaba, Luis ; Sidibe, David ; Thygesen, John ; Van der Kloot, Harrison ; Been, Laura E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a380t-4b498762eee9661d69bea9581b80728839ce0b8f40a70c00e53e11d8f0a11fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal</topic><topic>Animal Sex Differences</topic><topic>Animal Sexual Behavior</topic><topic>Animal Sexual Receptivity</topic><topic>Animals</topic><topic>Behavior</topic><topic>Behavioral plasticity</topic><topic>Brain - physiology</topic><topic>Copulation - physiology</topic><topic>Cricetinae</topic><topic>Dopamine</topic><topic>Drug abuse</topic><topic>Female</topic><topic>Females</topic><topic>FosB protein</topic><topic>Hamsters</topic><topic>Male</topic><topic>Males</topic><topic>Mesocricetus - metabolism</topic><topic>Mesolimbic system</topic><topic>Molecular modelling</topic><topic>Motivation</topic><topic>Motivation - physiology</topic><topic>Neural Plasticity</topic><topic>Neuronal Plasticity - physiology</topic><topic>Nucleus Accumbens</topic><topic>Nucleus Accumbens - physiology</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Proto-Oncogene Proteins c-fos - physiology</topic><topic>Reinforcement</topic><topic>Reward</topic><topic>Rewards</topic><topic>Rodents</topic><topic>Sex</topic><topic>Sex Factors</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Transcription Factors</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acaba, Luis</creatorcontrib><creatorcontrib>Sidibe, David</creatorcontrib><creatorcontrib>Thygesen, John</creatorcontrib><creatorcontrib>Van der Kloot, Harrison</creatorcontrib><creatorcontrib>Been, Laura E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acaba, Luis</au><au>Sidibe, David</au><au>Thygesen, John</au><au>Van der Kloot, Harrison</au><au>Been, Laura E</au><au>Burwell, Rebecca D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2019-08</date><risdate>2019</risdate><volume>133</volume><issue>4</issue><spage>378</spage><epage>384</epage><pages>378-384</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><abstract>Motivated behaviors share the common feature of activating the mesolimbic dopamine system. Repeated experience with motivated behaviors can cause long-lasting structural changes in the nucleus accumbens (NAc). The molecular mechanisms underlying this experience-dependent plasticity in the NAc have been well described following experience with drugs of abuse. In particular, the transcription factor Delta FosB (ΔFosB) is a key regulator of drug-related neuroplasticity. Fewer studies have examined the molecular mechanisms underlying experience-dependent plasticity in the NAc following naturally motivated behaviors, but previous research has demonstrated that sexual experience increases the accumulation of ΔFosB in the NAc of female hamsters and male rats. Sex behavior is unique among motivated behaviors in that the expression of the behavior varies drastically between males and females of the same species. Despite this, a quantitative comparison of ΔFosB following sex experience in males and females of the same species has never been conducted. We therefore used Western blotting to test the hypothesis that sex experience increases ΔFosB in both male and female Syrian hamsters following repeated sexual experience. We found that sex experience significantly increases ΔFosB protein in male and female Syrian hamsters. Further, ΔFosB protein levels did not differ between males and females following sex experience. Interestingly, repeated sex experience only led to increased copulatory efficiency in female hamsters; male copulatory efficiency did not improve with repeated experience. Together, these data demonstrate that ΔFosB is increased following sexual reward in both males and females but may be uncoupled from behavioral plasticity in males.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>30869949</pmid><doi>10.1037/bne0000313</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0735-7044
ispartof Behavioral neuroscience, 2019-08, Vol.133 (4), p.378-384
issn 0735-7044
1939-0084
language eng
recordid cdi_proquest_miscellaneous_2193167748
source MEDLINE; EBSCOhost APA PsycARTICLES
subjects Animal
Animal Sex Differences
Animal Sexual Behavior
Animal Sexual Receptivity
Animals
Behavior
Behavioral plasticity
Brain - physiology
Copulation - physiology
Cricetinae
Dopamine
Drug abuse
Female
Females
FosB protein
Hamsters
Male
Males
Mesocricetus - metabolism
Mesolimbic system
Molecular modelling
Motivation
Motivation - physiology
Neural Plasticity
Neuronal Plasticity - physiology
Nucleus Accumbens
Nucleus Accumbens - physiology
Proteins
Proto-Oncogene Proteins c-fos - metabolism
Proto-Oncogene Proteins c-fos - physiology
Reinforcement
Reward
Rewards
Rodents
Sex
Sex Factors
Sexual Behavior, Animal - physiology
Transcription Factors
Western blotting
title Sex Experience Increases Delta FosB in Male and Female Hamsters, but Facilitates Sex Behavior Only in Females
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T22%3A54%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20Experience%20Increases%20Delta%20FosB%20in%20Male%20and%20Female%20Hamsters,%20but%20Facilitates%20Sex%20Behavior%20Only%20in%20Females&rft.jtitle=Behavioral%20neuroscience&rft.au=Acaba,%20Luis&rft.date=2019-08&rft.volume=133&rft.issue=4&rft.spage=378&rft.epage=384&rft.pages=378-384&rft.issn=0735-7044&rft.eissn=1939-0084&rft_id=info:doi/10.1037/bne0000313&rft_dat=%3Cproquest_cross%3E2192053859%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2192053859&rft_id=info:pmid/30869949&rfr_iscdi=true