Molecular mechanisms of protein-bound uremic toxin-mediated cardiac, renal and vascular effects: underpinning intracellular targets for cardiorenal syndrome therapy

•There is an abundance of mechanistic studies involving the multi-organ effect of PBUTs.•We gathered evidence on molecular mechanisms in PBUT-mediated cardiac, renal and vascular effect.•Potential therapeutic targets to block PBUT adverse effects in the CRS setting based on mechanistic studies are a...

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