Sema3A - mediated modulation of NR1D1 expression may be involved in the regulation of axonal guidance signaling by the microbiota

The microbiota has a profound impact on host development and function. Axon guidance is essential for the formation of neural circuits and plays an important role in neurological diseases and behavioral disorders. However, the impact of the microbiota on axon guidance signaling is unclear. Gnotobiot...

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Veröffentlicht in:	Life sciences (1973) 2019-04, Vol.223, p.54-61
Hauptverfasser:	Qi, Xunzhong, Wang, Guowei, Zhong, Xiaogang, Zeng, Benhua, Chen, Jianjun, Zeng, Li, Bai, Shunjie, Xu, Shaohua, Wang, Wei, Cheng, Ke, Chen, Zhi, Wei, Hong, Xie, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Axon guidance Axon guidance signaling Axonogenesis Colonization Germfree Gnotobiotic Mice Microbiota Molecular modelling Neural networks Neurological diseases Neurons NR1D1 Phenotypes Prefrontal cortex Proteins Rho-associated kinase RhoA protein RhoA/ROCK pathway Rocks Sema3A Semaphorins Signal transduction Signaling Specific pathogen free Transcription
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