KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells

•We generated CDA patient-derived iPSCs carrying the KLF1 E325K mutation (CDA-iPSCs).•We developed an inducible expression system of KLF1 E325K using CDA-iPSCs.•We found that KLF1 E325K induced G1 cell cycle arrest at the CD71+/CD235a+ stage. Krüppel-like factor 1 (KLF1), a transcription factor cont...

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Veröffentlicht in:	Experimental hematology 2019-05, Vol.73, p.25-37.e8
Hauptverfasser:	Kohara, Hiroshi, Utsugisawa, Taiju, Sakamoto, Chika, Hirose, Lisa, Ogawa, Yoshie, Ogura, Hiromi, Sugawara, Ai, Liao, Jiyuan, Aoki, Takako, Iwasaki, Takuya, Asai, Takayoshi, Doisaki, Sayoko, Okuno, Yusuke, Muramatsu, Hideki, Abe, Takaaki, Kurita, Ryo, Miyamoto, Shohei, Sakuma, Tetsushi, Shiba, Masayuki, Yamamoto, Takashi, Ohga, Shouichi, Yoshida, Kenichi, Ogawa, Seishi, Ito, Etsuro, Kojima, Seiji, Kanno, Hitoshi, Tani, Kenzaburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Substitution Anemia, Dyserythropoietic, Congenital - genetics Anemia, Dyserythropoietic, Congenital - metabolism Anemia, Dyserythropoietic, Congenital - pathology Cell Differentiation - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Cyclin-Dependent Kinase Inhibitor p18 - genetics Cyclin-Dependent Kinase Inhibitor p18 - metabolism Erythroid Cells - metabolism Erythroid Cells - pathology Female G1 Phase Cell Cycle Checkpoints - genetics Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mutation, Missense
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