Balancing uncertainty with patient autonomy in precision medicine

By the nature of their unknown pathogenicity, variants of unknown significance (VUS) should not inform clinical decisions for genetic carrier testing; nevertheless, VUS are increasingly returned to patients. We argue that the benefits of returning VUS to patients are outweighed by the potential for...

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Veröffentlicht in:	Nature reviews. Genetics 2019-05, Vol.20 (5), p.251-252
Hauptverfasser:	Pollard, Samantha, Sun, Sophie, Regier, Dean A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144 631/208/2489/1512 631/208/457/649 631/208/727/2000 Agriculture Analysis Animal Genetics and Genomics Autonomy Biomedical and Life Sciences Biomedicine Cancer Cancer Research Clinical Decision-Making - ethics Comment Gene Function Genetic testing Genetic Testing - ethics Human Genetics Humans Medical care Pathogenicity Patients Penetrance Personal Autonomy Precision medicine Precision Medicine - ethics Retirement benefits Technology Uncertainty
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