H3K27M-Positive Primary Spinal Glioblastoma Presenting with Hemorrhage—A Rare Clinical Entity

Primary spinal glioblastoma multiforme is a rare and aggressive spinal tumor with dismal outcomes We have presented an unusual case—the first, to the best of our knowledge, to be reported—with intratumoral hemorrhage and sudden-onset quadriplegia in a patients with primary spinal glioblastoma multiforme. The patient underwent emergency surgical decompression. The patient died after a prolonged intensive care unit stay. The tumor was positive for histone molecular alteration, H3K27M.