DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?

Nucleoside reverse transcriptase inhibitors (NRTIs) form the backbone in combination antiretroviral therapy (cARVs). They halt chain elongation of the viral cDNA by acting as false substrates in counterfeit incorporation mechanism to viral RNA-dependent DNA polymerase. In the process genomic DNA pol...

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Veröffentlicht in:	European journal of pharmacology 2019-06, Vol.852, p.159-166
Hauptverfasser:	Lutu, Mathabo Ruth, Nzuza, Sanelisiwe, Mofo Mato, Pascale Edith, Govender, Khmera, Gumede, Londiwe Mphumelelo, Kumalo, Sinenhlanhla Innocentia, Mlambo, Nontokozo Nomfundo, Hurchund, Ranjendraparsad, Oroma Owira, Peter Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA polymerase Mitochondria Naringenin NRTIs
Online-Zugang:	Volltext
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