Regeneration of trachea graft with cartilage support, vascularization, and epithelization
[Display omitted] The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. The current study proposed a series of novel strategies for construct...
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| Veröffentlicht in: | Acta biomaterialia 2019-04, Vol.89, p.206-216 |
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| creator | Li, Dan Yin, Zongqi Liu, Yi Feng, Shaoqing Liu, Yu Lu, Fangjia Xu, Yong Min, Peiru Hou, Mengjie Li, Ke He, Aijuan Zhang, Wenjie Liu, Wei Zhang, Yixin Zhou, Guangdong Cao, Yilin |
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The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. The current study proposed a series of novel strategies for constructing a bionic living trachea substitute. For the issue of tubular cartilage support, cartilage sheet technique based on high-density culture of chondrocytes was adopted to avoid the inflammatory reaction triggered by the materials and thus formed mature cartilage-like tissue in autologous goat model. For the issue of epithelialization, the autologous transplantation of oral mucosal epithelium was used to realize mucosa coverage of the constructed trachea lumen. Finally, the flat trapezius fascia flap with double blood supply was separated by microsurgical techniques to achieve stable pre-vascularization of both the regenerated cartilage and the grafted epithelium simultaneously. By integrating the above strategies, the vascularized and epithelialized tracheal substitute with tubular cartilage support was successfully constructed in a goat model. The reconstructed trachea possessed a multiple layer structure of muscle-cartilage-fascia-mucosa comparable to the native trachea, and thus might realize stable survival and long-term airway function maintenance, providing a promising tracheal substitute for the repair and permanent functional reconstruction of long-segment tracheal defects.
The repair of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. In the current study, by technical integration of cartilage regeneration, microsurgery, and oral mucosa transplantation, a complex tracheal substitute with satisfactory vascularization, epithelialization, and tubular cartilage support was successfully constructed in a goat autologous model. The reconstructed trachea substitute possessed a multiple layer structure of muscle-cartilage-fascia-mucosa exactly similar to native trachea, and thus might realize stable survival and long-term airway function maintenance. The current study provides feasible strategies and ideal tracheal substitutes for permanent functional reconstruction of long-segmental trachea defects. |
| doi_str_mv | 10.1016/j.actbio.2019.03.003 |
| format | Article |
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The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. The current study proposed a series of novel strategies for constructing a bionic living trachea substitute. For the issue of tubular cartilage support, cartilage sheet technique based on high-density culture of chondrocytes was adopted to avoid the inflammatory reaction triggered by the materials and thus formed mature cartilage-like tissue in autologous goat model. For the issue of epithelialization, the autologous transplantation of oral mucosal epithelium was used to realize mucosa coverage of the constructed trachea lumen. Finally, the flat trapezius fascia flap with double blood supply was separated by microsurgical techniques to achieve stable pre-vascularization of both the regenerated cartilage and the grafted epithelium simultaneously. By integrating the above strategies, the vascularized and epithelialized tracheal substitute with tubular cartilage support was successfully constructed in a goat model. The reconstructed trachea possessed a multiple layer structure of muscle-cartilage-fascia-mucosa comparable to the native trachea, and thus might realize stable survival and long-term airway function maintenance, providing a promising tracheal substitute for the repair and permanent functional reconstruction of long-segment tracheal defects.
The repair of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. In the current study, by technical integration of cartilage regeneration, microsurgery, and oral mucosa transplantation, a complex tracheal substitute with satisfactory vascularization, epithelialization, and tubular cartilage support was successfully constructed in a goat autologous model. The reconstructed trachea substitute possessed a multiple layer structure of muscle-cartilage-fascia-mucosa exactly similar to native trachea, and thus might realize stable survival and long-term airway function maintenance. The current study provides feasible strategies and ideal tracheal substitutes for permanent functional reconstruction of long-segmental trachea defects.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2019.03.003</identifier><identifier>PMID: 30867137</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Autografts ; Bionics ; Cartilage ; Cartilage - metabolism ; Cartilage - pathology ; Cartilage - transplantation ; Cartilage regeneration ; Chondrocytes ; Chondrocytes - metabolism ; Chondrocytes - pathology ; Construction ; Defects ; Epithelium ; Epithelization ; Fascia ; Feasibility studies ; Female ; Goats ; Inflammation ; Knee ; Male ; Microsurgery ; Mucosa ; Muscles ; Neovascularization, Physiologic ; Reconstruction ; Regeneration ; Repair ; Respiratory tract ; Substitutes ; Surgery ; Survival ; Tissue engineering ; Trachea ; Trachea - physiology ; Tracheal reconstruction ; Transplantation ; Vascularization</subject><ispartof>Acta biomaterialia, 2019-04, Vol.89, p.206-216</ispartof><rights>2019 Acta Materialia Inc.</rights><rights>Copyright © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Apr 15, 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-ff5f5c56a70603cda83b63cb5c98b9c397d6c8b213ce313119b6e98f8bf491413</citedby><cites>FETCH-LOGICAL-c427t-ff5f5c56a70603cda83b63cb5c98b9c397d6c8b213ce313119b6e98f8bf491413</cites><orcidid>0000-0002-0818-660X ; 0000-0003-2488-2733</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2019.03.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30867137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Dan</creatorcontrib><creatorcontrib>Yin, Zongqi</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Feng, Shaoqing</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Lu, Fangjia</creatorcontrib><creatorcontrib>Xu, Yong</creatorcontrib><creatorcontrib>Min, Peiru</creatorcontrib><creatorcontrib>Hou, Mengjie</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>He, Aijuan</creatorcontrib><creatorcontrib>Zhang, Wenjie</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Zhang, Yixin</creatorcontrib><creatorcontrib>Zhou, Guangdong</creatorcontrib><creatorcontrib>Cao, Yilin</creatorcontrib><title>Regeneration of trachea graft with cartilage support, vascularization, and epithelization</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. The current study proposed a series of novel strategies for constructing a bionic living trachea substitute. For the issue of tubular cartilage support, cartilage sheet technique based on high-density culture of chondrocytes was adopted to avoid the inflammatory reaction triggered by the materials and thus formed mature cartilage-like tissue in autologous goat model. For the issue of epithelialization, the autologous transplantation of oral mucosal epithelium was used to realize mucosa coverage of the constructed trachea lumen. Finally, the flat trapezius fascia flap with double blood supply was separated by microsurgical techniques to achieve stable pre-vascularization of both the regenerated cartilage and the grafted epithelium simultaneously. By integrating the above strategies, the vascularized and epithelialized tracheal substitute with tubular cartilage support was successfully constructed in a goat model. The reconstructed trachea possessed a multiple layer structure of muscle-cartilage-fascia-mucosa comparable to the native trachea, and thus might realize stable survival and long-term airway function maintenance, providing a promising tracheal substitute for the repair and permanent functional reconstruction of long-segment tracheal defects.
The repair of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. In the current study, by technical integration of cartilage regeneration, microsurgery, and oral mucosa transplantation, a complex tracheal substitute with satisfactory vascularization, epithelialization, and tubular cartilage support was successfully constructed in a goat autologous model. The reconstructed trachea substitute possessed a multiple layer structure of muscle-cartilage-fascia-mucosa exactly similar to native trachea, and thus might realize stable survival and long-term airway function maintenance. The current study provides feasible strategies and ideal tracheal substitutes for permanent functional reconstruction of long-segmental trachea defects.</description><subject>Animals</subject><subject>Autografts</subject><subject>Bionics</subject><subject>Cartilage</subject><subject>Cartilage - metabolism</subject><subject>Cartilage - pathology</subject><subject>Cartilage - transplantation</subject><subject>Cartilage regeneration</subject><subject>Chondrocytes</subject><subject>Chondrocytes - metabolism</subject><subject>Chondrocytes - pathology</subject><subject>Construction</subject><subject>Defects</subject><subject>Epithelium</subject><subject>Epithelization</subject><subject>Fascia</subject><subject>Feasibility studies</subject><subject>Female</subject><subject>Goats</subject><subject>Inflammation</subject><subject>Knee</subject><subject>Male</subject><subject>Microsurgery</subject><subject>Mucosa</subject><subject>Muscles</subject><subject>Neovascularization, Physiologic</subject><subject>Reconstruction</subject><subject>Regeneration</subject><subject>Repair</subject><subject>Respiratory tract</subject><subject>Substitutes</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tissue engineering</subject><subject>Trachea</subject><subject>Trachea - 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Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Dan</au><au>Yin, Zongqi</au><au>Liu, Yi</au><au>Feng, Shaoqing</au><au>Liu, Yu</au><au>Lu, Fangjia</au><au>Xu, Yong</au><au>Min, Peiru</au><au>Hou, Mengjie</au><au>Li, Ke</au><au>He, Aijuan</au><au>Zhang, Wenjie</au><au>Liu, Wei</au><au>Zhang, Yixin</au><au>Zhou, Guangdong</au><au>Cao, Yilin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regeneration of trachea graft with cartilage support, vascularization, and epithelization</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2019-04-15</date><risdate>2019</risdate><volume>89</volume><spage>206</spage><epage>216</epage><pages>206-216</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. The current study proposed a series of novel strategies for constructing a bionic living trachea substitute. For the issue of tubular cartilage support, cartilage sheet technique based on high-density culture of chondrocytes was adopted to avoid the inflammatory reaction triggered by the materials and thus formed mature cartilage-like tissue in autologous goat model. For the issue of epithelialization, the autologous transplantation of oral mucosal epithelium was used to realize mucosa coverage of the constructed trachea lumen. Finally, the flat trapezius fascia flap with double blood supply was separated by microsurgical techniques to achieve stable pre-vascularization of both the regenerated cartilage and the grafted epithelium simultaneously. By integrating the above strategies, the vascularized and epithelialized tracheal substitute with tubular cartilage support was successfully constructed in a goat model. The reconstructed trachea possessed a multiple layer structure of muscle-cartilage-fascia-mucosa comparable to the native trachea, and thus might realize stable survival and long-term airway function maintenance, providing a promising tracheal substitute for the repair and permanent functional reconstruction of long-segment tracheal defects.
The repair of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. In the current study, by technical integration of cartilage regeneration, microsurgery, and oral mucosa transplantation, a complex tracheal substitute with satisfactory vascularization, epithelialization, and tubular cartilage support was successfully constructed in a goat autologous model. The reconstructed trachea substitute possessed a multiple layer structure of muscle-cartilage-fascia-mucosa exactly similar to native trachea, and thus might realize stable survival and long-term airway function maintenance. The current study provides feasible strategies and ideal tracheal substitutes for permanent functional reconstruction of long-segmental trachea defects.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30867137</pmid><doi>10.1016/j.actbio.2019.03.003</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0818-660X</orcidid><orcidid>https://orcid.org/0000-0003-2488-2733</orcidid></addata></record> |
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| subjects | Animals Autografts Bionics Cartilage Cartilage - metabolism Cartilage - pathology Cartilage - transplantation Cartilage regeneration Chondrocytes Chondrocytes - metabolism Chondrocytes - pathology Construction Defects Epithelium Epithelization Fascia Feasibility studies Female Goats Inflammation Knee Male Microsurgery Mucosa Muscles Neovascularization, Physiologic Reconstruction Regeneration Repair Respiratory tract Substitutes Surgery Survival Tissue engineering Trachea Trachea - physiology Tracheal reconstruction Transplantation Vascularization |
| title | Regeneration of trachea graft with cartilage support, vascularization, and epithelization |
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