Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma
Epidermal growth factor receptor (EGFR) signaling plays an important role in various cancers, including hepatocellular carcinoma (HCC). We aimed to evaluate immunoexpression of EGFR in HCC and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathologic data. We analyzed 60 p...
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| Veröffentlicht in: | Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) 2018-12, Vol.39 (2), p.21-28 |
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| creator | Nikolova, Dafina Chalovska, Viktorija Ivanova, Magdalena Genadieva Nikolovska, Emilija Volkanovska, Ance Orovchanec, Nikola Kunovska, Slavica Kostadinova Petrushevska, Gordana Janevska, Vesna |
| description | Epidermal growth factor receptor (EGFR) signaling plays an important role in various cancers, including hepatocellular carcinoma (HCC). We aimed to evaluate immunoexpression of EGFR in HCC and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathologic data.
We analyzed 60 patients with HCC for multiple clinicopathologic characteristics and survival.
Presence of the immunosignal and the percentage of positive tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined.
Nineteen patients (31.67%) were female and 41 (68.33%) were male ranging in age from 31 to 85 years, median 61.88±10.51.
Mean survival time for female patients was 8.86±1.76 months, for male 13.03±1.50 months and overall survival was 11.6051±1.19 months.
The most patients had: T2 status (41.67%), no enlarged lymph nodes (90%), vascular invasion (63.33%) and well differentiated (43.33%) tumors.
EGFR immunoexpression was determined in range from 0% to 100% in both tumor and non-tumor tissue with mean value of 39.58% in tumor and 86.86% in cirrhotic tissue (p |
| doi_str_mv | 10.2478/prilozi-2018-0038 |
| format | Article |
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We analyzed 60 patients with HCC for multiple clinicopathologic characteristics and survival.
Presence of the immunosignal and the percentage of positive tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined.
Nineteen patients (31.67%) were female and 41 (68.33%) were male ranging in age from 31 to 85 years, median 61.88±10.51.
Mean survival time for female patients was 8.86±1.76 months, for male 13.03±1.50 months and overall survival was 11.6051±1.19 months.
The most patients had: T2 status (41.67%), no enlarged lymph nodes (90%), vascular invasion (63.33%) and well differentiated (43.33%) tumors.
EGFR immunoexpression was determined in range from 0% to 100% in both tumor and non-tumor tissue with mean value of 39.58% in tumor and 86.86% in cirrhotic tissue (p<0.00).
Higher percent of tumor EGFR positive cells were found in cases with higher T status, higher levels of AFP and poorly differentiated carcinoma, but not significantly.
Lower percent of tumor EGFR positive cells were found in patients with vascular invasion and enlarged lymph nodes, but also not significantly.
EGFR expression in tumor tissue significantly influenced survival of the patients (p<0.05).
The study showed that expression of EGFR in lower percentage of tumor cells was associated to favorable prognosis, making it a potential prognostic marker and therapeutic target.</description><identifier>ISSN: 1857-9345</identifier><identifier>EISSN: 1857-9345</identifier><identifier>EISSN: 0350-1914</identifier><identifier>DOI: 10.2478/prilozi-2018-0038</identifier><identifier>PMID: 30864368</identifier><language>eng</language><publisher>Macedonia: Sciendo</publisher><subject>cirrhosis ; EGFR ; Epidermal growth factor ; HCC ; immunohistochemistry ; Liver cancer ; Lymphatic system ; Medical prognosis ; survival</subject><ispartof>Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki), 2018-12, Vol.39 (2), p.21-28</ispartof><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2741-d6b3bfc19b52d44b766776b5dd2a38a695d8a30b6803ee5f2f5a70340edd55a33</citedby><cites>FETCH-LOGICAL-c2741-d6b3bfc19b52d44b766776b5dd2a38a695d8a30b6803ee5f2f5a70340edd55a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://sciendo.com/pdf/10.2478/prilozi-2018-0038$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://sciendo.com/article/10.2478/prilozi-2018-0038$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,75907,75908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30864368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikolova, Dafina</creatorcontrib><creatorcontrib>Chalovska, Viktorija</creatorcontrib><creatorcontrib>Ivanova, Magdalena Genadieva</creatorcontrib><creatorcontrib>Nikolovska, Emilija</creatorcontrib><creatorcontrib>Volkanovska, Ance</creatorcontrib><creatorcontrib>Orovchanec, Nikola</creatorcontrib><creatorcontrib>Kunovska, Slavica Kostadinova</creatorcontrib><creatorcontrib>Petrushevska, Gordana</creatorcontrib><creatorcontrib>Janevska, Vesna</creatorcontrib><title>Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma</title><title>Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)</title><addtitle>Pril (Makedon Akad Nauk Umet Odd Med Nauki)</addtitle><description>Epidermal growth factor receptor (EGFR) signaling plays an important role in various cancers, including hepatocellular carcinoma (HCC). We aimed to evaluate immunoexpression of EGFR in HCC and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathologic data.
We analyzed 60 patients with HCC for multiple clinicopathologic characteristics and survival.
Presence of the immunosignal and the percentage of positive tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined.
Nineteen patients (31.67%) were female and 41 (68.33%) were male ranging in age from 31 to 85 years, median 61.88±10.51.
Mean survival time for female patients was 8.86±1.76 months, for male 13.03±1.50 months and overall survival was 11.6051±1.19 months.
The most patients had: T2 status (41.67%), no enlarged lymph nodes (90%), vascular invasion (63.33%) and well differentiated (43.33%) tumors.
EGFR immunoexpression was determined in range from 0% to 100% in both tumor and non-tumor tissue with mean value of 39.58% in tumor and 86.86% in cirrhotic tissue (p<0.00).
Higher percent of tumor EGFR positive cells were found in cases with higher T status, higher levels of AFP and poorly differentiated carcinoma, but not significantly.
Lower percent of tumor EGFR positive cells were found in patients with vascular invasion and enlarged lymph nodes, but also not significantly.
EGFR expression in tumor tissue significantly influenced survival of the patients (p<0.05).
The study showed that expression of EGFR in lower percentage of tumor cells was associated to favorable prognosis, making it a potential prognostic marker and therapeutic target.</description><subject>cirrhosis</subject><subject>EGFR</subject><subject>Epidermal growth factor</subject><subject>HCC</subject><subject>immunohistochemistry</subject><subject>Liver cancer</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>survival</subject><issn>1857-9345</issn><issn>1857-9345</issn><issn>0350-1914</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kEtr3DAUhUVpaEKaH9BNMWTTjRO9Je8ahskDAoWSbCNk67qjYFuuZJPHr4_MTJoQ6EoH8d3D4UPoG8EnlCt9OkbfhWdfUkx0iTHTn9AB0UKVFePi87u8j45SuscYE0mEZuIL2mdYS86kPkB3V30_D2Hj0xSaDfS-sV2xfhwjpOTDUIS2WI_eQezz_0UMD9OmOLfNFGLxGxoYl-CH4hJGmwug6-bOxmJlY-OH0NuvaK-1XYKj3XuIbs_XN6vL8vrXxdXq7LpsqOKkdLJmdduQqhbUcV4rKZWStXCOWqatrITTluFaaswAREtbYRVmHINzQljGDtGPbe8Yw98Z0mR6n5Y5doAwJ0NJRTChXJCMHn9A78Mch7zOMCIUx1JUKlNkSzUxpBShNdl3b-OTIdgs_s3Ov1n8m8V_vvm-a57rHty_i1fbGfi5BR5sN0F08CfOTzm8Lfh_eUUNo4S9AI48mJA</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Nikolova, Dafina</creator><creator>Chalovska, Viktorija</creator><creator>Ivanova, Magdalena Genadieva</creator><creator>Nikolovska, Emilija</creator><creator>Volkanovska, Ance</creator><creator>Orovchanec, Nikola</creator><creator>Kunovska, Slavica Kostadinova</creator><creator>Petrushevska, Gordana</creator><creator>Janevska, Vesna</creator><general>Sciendo</general><general>De Gruyter Poland</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma</title><author>Nikolova, Dafina ; Chalovska, Viktorija ; Ivanova, Magdalena Genadieva ; Nikolovska, Emilija ; Volkanovska, Ance ; Orovchanec, Nikola ; Kunovska, Slavica Kostadinova ; Petrushevska, Gordana ; Janevska, Vesna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2741-d6b3bfc19b52d44b766776b5dd2a38a695d8a30b6803ee5f2f5a70340edd55a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>cirrhosis</topic><topic>EGFR</topic><topic>Epidermal growth factor</topic><topic>HCC</topic><topic>immunohistochemistry</topic><topic>Liver cancer</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikolova, Dafina</creatorcontrib><creatorcontrib>Chalovska, Viktorija</creatorcontrib><creatorcontrib>Ivanova, Magdalena Genadieva</creatorcontrib><creatorcontrib>Nikolovska, Emilija</creatorcontrib><creatorcontrib>Volkanovska, Ance</creatorcontrib><creatorcontrib>Orovchanec, Nikola</creatorcontrib><creatorcontrib>Kunovska, Slavica Kostadinova</creatorcontrib><creatorcontrib>Petrushevska, Gordana</creatorcontrib><creatorcontrib>Janevska, Vesna</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikolova, Dafina</au><au>Chalovska, Viktorija</au><au>Ivanova, Magdalena Genadieva</au><au>Nikolovska, Emilija</au><au>Volkanovska, Ance</au><au>Orovchanec, Nikola</au><au>Kunovska, Slavica Kostadinova</au><au>Petrushevska, Gordana</au><au>Janevska, Vesna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma</atitle><jtitle>Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)</jtitle><addtitle>Pril (Makedon Akad Nauk Umet Odd Med Nauki)</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>39</volume><issue>2</issue><spage>21</spage><epage>28</epage><pages>21-28</pages><issn>1857-9345</issn><eissn>1857-9345</eissn><eissn>0350-1914</eissn><abstract>Epidermal growth factor receptor (EGFR) signaling plays an important role in various cancers, including hepatocellular carcinoma (HCC). We aimed to evaluate immunoexpression of EGFR in HCC and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathologic data.
We analyzed 60 patients with HCC for multiple clinicopathologic characteristics and survival.
Presence of the immunosignal and the percentage of positive tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined.
Nineteen patients (31.67%) were female and 41 (68.33%) were male ranging in age from 31 to 85 years, median 61.88±10.51.
Mean survival time for female patients was 8.86±1.76 months, for male 13.03±1.50 months and overall survival was 11.6051±1.19 months.
The most patients had: T2 status (41.67%), no enlarged lymph nodes (90%), vascular invasion (63.33%) and well differentiated (43.33%) tumors.
EGFR immunoexpression was determined in range from 0% to 100% in both tumor and non-tumor tissue with mean value of 39.58% in tumor and 86.86% in cirrhotic tissue (p<0.00).
Higher percent of tumor EGFR positive cells were found in cases with higher T status, higher levels of AFP and poorly differentiated carcinoma, but not significantly.
Lower percent of tumor EGFR positive cells were found in patients with vascular invasion and enlarged lymph nodes, but also not significantly.
EGFR expression in tumor tissue significantly influenced survival of the patients (p<0.05).
The study showed that expression of EGFR in lower percentage of tumor cells was associated to favorable prognosis, making it a potential prognostic marker and therapeutic target.</abstract><cop>Macedonia</cop><pub>Sciendo</pub><pmid>30864368</pmid><doi>10.2478/prilozi-2018-0038</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1857-9345 |
| ispartof | Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki), 2018-12, Vol.39 (2), p.21-28 |
| issn | 1857-9345 1857-9345 0350-1914 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2191012451 |
| source | Alma/SFX Local Collection; Walter De Gruyter: Open Access Journals |
| subjects | cirrhosis EGFR Epidermal growth factor HCC immunohistochemistry Liver cancer Lymphatic system Medical prognosis survival |
| title | Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma |
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