Prognostic Factors for Survival After Extracorporeal Membrane Oxygenation for Cardiogenic Shock
The aim of this study is to examine factors that can predict mortality in patients that have veno-arterial extracorporeal membrane oxygenation (VA-ECMO) instituted for cardiogenic shock. A single-center, retrospective study of 127 patients who underwent VA-ECMO for cardiogenic shock between January...
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| Veröffentlicht in: | ASAIO journal (1992) 2020-02, Vol.66 (2), p.141-145 |
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| container_title | ASAIO journal (1992) |
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| creator | Huang, Mingjie Ong, Boon Hean Hoo, Anne Ean Ean Gao, Fei Chao, Victor Tar Toong Lim, Chong Hee Tan, Teing Ee Sin, Kenny Yoong Kong |
| description | The aim of this study is to examine factors that can predict mortality in patients that have veno-arterial extracorporeal membrane oxygenation (VA-ECMO) instituted for cardiogenic shock. A single-center, retrospective study of 127 patients who underwent VA-ECMO for cardiogenic shock between January 2003 and December 2017 was conducted. Eighty-three (65%) patients survived to weaning or bridging therapy. Complications on VA-ECMO includehemorrhage (40%), stroke (14%), requirement for dialysis (42%), and limb ischemia (24%). Univariate analysis revealed shorter ECMO duration, higher body mass index, preimplantation creatinine > 100 mmol/l, lower preimplantation serum albumin, and the development of stroke or limb ischemia on ECMO to be significantly associated with mortality while on ECMO. Multivariate analysis by logistic regression found shorter ECMO duration and lower preimplantation serum albumin to be significantly associated with mortality. VA-ECMO is an effective strategy in treating patients with cardiogenic shock and provides a reasonable chance of survival to weaning or bridging to other therapy. Preimplantation hypoalbuminemia, preimplantation serum creatinine > 100 mmol/l, and the development of stroke and limb ischemia while on VA-ECMO are strongly associated with mortality. |
| doi_str_mv | 10.1097/MAT.0000000000000984 |
| format | Article |
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A single-center, retrospective study of 127 patients who underwent VA-ECMO for cardiogenic shock between January 2003 and December 2017 was conducted. Eighty-three (65%) patients survived to weaning or bridging therapy. Complications on VA-ECMO includehemorrhage (40%), stroke (14%), requirement for dialysis (42%), and limb ischemia (24%). Univariate analysis revealed shorter ECMO duration, higher body mass index, preimplantation creatinine > 100 mmol/l, lower preimplantation serum albumin, and the development of stroke or limb ischemia on ECMO to be significantly associated with mortality while on ECMO. Multivariate analysis by logistic regression found shorter ECMO duration and lower preimplantation serum albumin to be significantly associated with mortality. VA-ECMO is an effective strategy in treating patients with cardiogenic shock and provides a reasonable chance of survival to weaning or bridging to other therapy. Preimplantation hypoalbuminemia, preimplantation serum creatinine > 100 mmol/l, and the development of stroke and limb ischemia while on VA-ECMO are strongly associated with mortality.</description><identifier>ISSN: 1058-2916</identifier><identifier>EISSN: 1538-943X</identifier><identifier>DOI: 10.1097/MAT.0000000000000984</identifier><identifier>PMID: 30864968</identifier><language>eng</language><publisher>United States: The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO</publisher><subject>Extracorporeal Membrane Oxygenation - adverse effects ; Extracorporeal Membrane Oxygenation - mortality ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Retrospective Studies ; Shock, Cardiogenic - mortality ; Shock, Cardiogenic - therapy</subject><ispartof>ASAIO journal (1992), 2020-02, Vol.66 (2), p.141-145</ispartof><rights>The Author(s). 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A single-center, retrospective study of 127 patients who underwent VA-ECMO for cardiogenic shock between January 2003 and December 2017 was conducted. Eighty-three (65%) patients survived to weaning or bridging therapy. Complications on VA-ECMO includehemorrhage (40%), stroke (14%), requirement for dialysis (42%), and limb ischemia (24%). Univariate analysis revealed shorter ECMO duration, higher body mass index, preimplantation creatinine > 100 mmol/l, lower preimplantation serum albumin, and the development of stroke or limb ischemia on ECMO to be significantly associated with mortality while on ECMO. Multivariate analysis by logistic regression found shorter ECMO duration and lower preimplantation serum albumin to be significantly associated with mortality. VA-ECMO is an effective strategy in treating patients with cardiogenic shock and provides a reasonable chance of survival to weaning or bridging to other therapy. Preimplantation hypoalbuminemia, preimplantation serum creatinine > 100 mmol/l, and the development of stroke and limb ischemia while on VA-ECMO are strongly associated with mortality.</description><subject>Extracorporeal Membrane Oxygenation - adverse effects</subject><subject>Extracorporeal Membrane Oxygenation - mortality</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Shock, Cardiogenic - mortality</subject><subject>Shock, Cardiogenic - therapy</subject><issn>1058-2916</issn><issn>1538-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP7CAcxYnR-P4G5qZLN9U_rwLLycRRE40mauKOQAecameYC62Pby919ObGhRISyOGcA_wQOsBwhEGJ48vR7RH8P5Rka2gbcypLxej9et4DlyVRuNpCOyk9AuRDijfRFgVZMVXJbaSvY3hYhNQ1dTExdRdiKnyIxU0fn5tn0xYj37lYnLx20dQhLkN0Wbx0cxvNwhVXr28PbmG6Jiw-YmMTp03IUq67mYX6aQ9teNMmt_-57qK7ycnt-Ky8uDo9H48uyppjykoxBStpJZWqiDSEYemJYNZ6y61X0lJGKRdiaokXwjDOwfDhY8JxoNZzuosOV73LGP72LnV63qTatW1-ZeiTJlhhwCBAZCtbWesYUorO62Vs5ia-aQx6QKszWv0dbY79-byht3M3_Rf6YpkNcmV4CW1mlp7a_sVFPcvAutlv3eyH6OAiTEJJgMAwoRykir4DptqUvg</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Huang, Mingjie</creator><creator>Ong, Boon Hean</creator><creator>Hoo, Anne Ean Ean</creator><creator>Gao, Fei</creator><creator>Chao, Victor Tar Toong</creator><creator>Lim, Chong Hee</creator><creator>Tan, Teing Ee</creator><creator>Sin, Kenny Yoong Kong</creator><general>The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO</general><general>Copyright by the American Society for Artificial Internal Organs</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200201</creationdate><title>Prognostic Factors for Survival After Extracorporeal Membrane Oxygenation for Cardiogenic Shock</title><author>Huang, Mingjie ; Ong, Boon Hean ; Hoo, Anne Ean Ean ; Gao, Fei ; Chao, Victor Tar Toong ; Lim, Chong Hee ; Tan, Teing Ee ; Sin, Kenny Yoong Kong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5134-7d0b836899628a2418f274bbfb5bf98b3433577db2f77a4550a529167e503bf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Extracorporeal Membrane Oxygenation - adverse effects</topic><topic>Extracorporeal Membrane Oxygenation - mortality</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Shock, Cardiogenic - mortality</topic><topic>Shock, Cardiogenic - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Mingjie</creatorcontrib><creatorcontrib>Ong, Boon Hean</creatorcontrib><creatorcontrib>Hoo, Anne Ean Ean</creatorcontrib><creatorcontrib>Gao, Fei</creatorcontrib><creatorcontrib>Chao, Victor Tar Toong</creatorcontrib><creatorcontrib>Lim, Chong Hee</creatorcontrib><creatorcontrib>Tan, Teing Ee</creatorcontrib><creatorcontrib>Sin, Kenny Yoong Kong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ASAIO journal (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Mingjie</au><au>Ong, Boon Hean</au><au>Hoo, Anne Ean Ean</au><au>Gao, Fei</au><au>Chao, Victor Tar Toong</au><au>Lim, Chong Hee</au><au>Tan, Teing Ee</au><au>Sin, Kenny Yoong Kong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Factors for Survival After Extracorporeal Membrane Oxygenation for Cardiogenic Shock</atitle><jtitle>ASAIO journal (1992)</jtitle><addtitle>ASAIO J</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>66</volume><issue>2</issue><spage>141</spage><epage>145</epage><pages>141-145</pages><issn>1058-2916</issn><eissn>1538-943X</eissn><abstract>The aim of this study is to examine factors that can predict mortality in patients that have veno-arterial extracorporeal membrane oxygenation (VA-ECMO) instituted for cardiogenic shock. A single-center, retrospective study of 127 patients who underwent VA-ECMO for cardiogenic shock between January 2003 and December 2017 was conducted. Eighty-three (65%) patients survived to weaning or bridging therapy. Complications on VA-ECMO includehemorrhage (40%), stroke (14%), requirement for dialysis (42%), and limb ischemia (24%). Univariate analysis revealed shorter ECMO duration, higher body mass index, preimplantation creatinine > 100 mmol/l, lower preimplantation serum albumin, and the development of stroke or limb ischemia on ECMO to be significantly associated with mortality while on ECMO. Multivariate analysis by logistic regression found shorter ECMO duration and lower preimplantation serum albumin to be significantly associated with mortality. VA-ECMO is an effective strategy in treating patients with cardiogenic shock and provides a reasonable chance of survival to weaning or bridging to other therapy. Preimplantation hypoalbuminemia, preimplantation serum creatinine > 100 mmol/l, and the development of stroke and limb ischemia while on VA-ECMO are strongly associated with mortality.</abstract><cop>United States</cop><pub>The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO</pub><pmid>30864968</pmid><doi>10.1097/MAT.0000000000000984</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Extracorporeal Membrane Oxygenation - adverse effects Extracorporeal Membrane Oxygenation - mortality Female Humans Logistic Models Male Middle Aged Multivariate Analysis Prognosis Retrospective Studies Shock, Cardiogenic - mortality Shock, Cardiogenic - therapy |
| title | Prognostic Factors for Survival After Extracorporeal Membrane Oxygenation for Cardiogenic Shock |
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