LIMK1 depletion enhances fasudil‐dependent inhibition of urethral fibroblast proliferation and migration

LIM kinase 1 (LIMK1) is an important regulator of the cell cytoskeleton. This study aimed to examine the role of LIMK1 in mediating the effects of the Rho kinase (ROCK) inhibitor fasudil. In vitro cultures of urethral fibroblasts were divided into LIMK1 knockdown (LIMK1 KD) and LIMK1 control (LIMK1...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-08, Vol.120 (8), p.12977-12988
Hauptverfasser:	Liang, Ying‐Chun, Li, Xiao‐Dong, Wu, Yu‐Peng, Ke, Zhi‐Bin, Liu, Zhang‐Qi, Chen, Shao‐Hao, Wei, Yong, Zheng, Qing‐Shui, Xue, Xue‐Yi, Xu, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Apoptosis Attenuation Cell adhesion & migration Cell migration Cofilin Collagen Collagen (type I) Collagen (type III) Cytoskeleton Depletion Enzyme inhibitors fasudil Fibroblasts Flow cytometry Growth factors Kinases LIM kinase LIMK1 Muscles Myosin p‐Cofilin Rho-associated kinase RNA interference Rocks Smooth muscle Tissues Transforming growth factor Urethra urethral fibroblast Wound healing
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