Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi

Chagas disease (CD) is a neglected parasitic condition endemic in the Americas caused by Trypanosoma cruzi. Patients present an acute phase that may or not be symptomatic, followed by lifelong chronic stage, mostly indeterminate, or with cardiac and/or digestive progressive lesions. Benznidazole (BZ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Parasitology 2019-07, Vol.146 (8), p.1006-1012
Hauptverfasser:	Simões-Silva, M. R., De Araújo, J. S., Peres, R. B., Da Silva, P. B., Batista, M. M., De Azevedo, L. D., Bastos, M. M., Bahia, M. T., Boechat, N., Soeiro, M. N. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilide Animals Benznidazole Cell culture Cell Line Chagas disease Chagas Disease - drug therapy Derivatives Drug Repositioning Drug screening Drug Therapy, Combination Enzyme inhibitors Fibroblasts Imatinib Imatinib Mesylate - pharmacology Kinases Lesions Mice Microscopy Nifurtimox Nitroimidazoles - pharmacology Parasites Parasitic diseases Protein-tyrosine kinase Public health Selectivity Therapy Tropical diseases Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects Tyrosine Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!