Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients
Diabetes mellitus is the most common metabolic disorder worldwide. This study examined the effect of turmeric supplementation on glycemic status, lipid profile, hs‐CRP and total antioxidant capacity in hyperlipidemic type 2 diabetic patients. In this double‐blind, randomized clinical trial, 80 hyper...
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| Veröffentlicht in: | Phytotherapy research 2019-04, Vol.33 (4), p.1173-1181 |
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| creator | Adab, Zohreh Eghtesadi, Shahryar Vafa, Mohammad‐Reza Heydari, Iraj Shojaii, Asieh Haqqani, Hamid Arablou, Tahereh Eghtesadi, Maryam |
| description | Diabetes mellitus is the most common metabolic disorder worldwide. This study examined the effect of turmeric supplementation on glycemic status, lipid profile, hs‐CRP and total antioxidant capacity in hyperlipidemic type 2 diabetic patients. In this double‐blind, randomized clinical trial, 80 hyperlipidemic type 2 diabetic patients were divided into turmeric (2,100 mg powdered rhizome of turmeric daily) and placebo groups for 8 weeks. Body weight, fasting plasma glucose, hemoglobin A1c (HbA1c), serum insulin, triglyceride (TG), total cholesterol, low density lypoprotein cholesterol (LDL‐c), high density lypoprotein cholesterol, apolipoprotein A1, apolipoprotein B, high sensitivity C‐reactive protein (hs‐CRP), and total antioxidant capacity were measured before and after intervention. Statistical analysis was carried out using paired and independent t and chi‐square tests. Seventy five patients completed the study. The turmeric group showed significant decreases in body weight, TG, and LDL‐c compared with baseline (p value |
| doi_str_mv | 10.1002/ptr.6312 |
| format | Article |
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This study examined the effect of turmeric supplementation on glycemic status, lipid profile, hs‐CRP and total antioxidant capacity in hyperlipidemic type 2 diabetic patients. In this double‐blind, randomized clinical trial, 80 hyperlipidemic type 2 diabetic patients were divided into turmeric (2,100 mg powdered rhizome of turmeric daily) and placebo groups for 8 weeks. Body weight, fasting plasma glucose, hemoglobin A1c (HbA1c), serum insulin, triglyceride (TG), total cholesterol, low density lypoprotein cholesterol (LDL‐c), high density lypoprotein cholesterol, apolipoprotein A1, apolipoprotein B, high sensitivity C‐reactive protein (hs‐CRP), and total antioxidant capacity were measured before and after intervention. Statistical analysis was carried out using paired and independent t and chi‐square tests. Seventy five patients completed the study. The turmeric group showed significant decreases in body weight, TG, and LDL‐c compared with baseline (p value < 0.05). Body mass index, TG, and total cholesterol decreased significantly in the turmeric group compared with the placebo group (p value < 0.05). No significant changes were observed in other parameters between the two groups after intervention (p value < 0.05). Turmeric improved some fractions of lipid profile and decreased body weight in hyperlipidemic patients with type 2 diabetes. It had no significant effect on glycemic status, hs‐CRP, and total antioxidant capacity in these patients.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.6312</identifier><identifier>PMID: 30859660</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Antioxidants ; Apolipoprotein B ; Apolipoproteins ; Aquatic plants ; Body mass ; Body mass index ; Body size ; Body weight ; Cholesterol ; Clinical trials ; Density ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; glycemic status ; Hemoglobin ; hs‐CRP ; Insulin ; lipid profile ; Lipids ; Low density lipoprotein ; Metabolic disorders ; Rhizomes ; Statistical analysis ; Supplements ; total antioxidant capacity ; Triglycerides ; turmeric ; type 2 diabetes</subject><ispartof>Phytotherapy research, 2019-04, Vol.33 (4), p.1173-1181</ispartof><rights>2019 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-66ea0fbd7ebde54751fb0a5a8322b889f208fa57f15e0bf7d036a20c6c9178ad3</citedby><cites>FETCH-LOGICAL-c3492-66ea0fbd7ebde54751fb0a5a8322b889f208fa57f15e0bf7d036a20c6c9178ad3</cites><orcidid>0000-0001-9140-0365</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.6312$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.6312$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30859660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adab, Zohreh</creatorcontrib><creatorcontrib>Eghtesadi, Shahryar</creatorcontrib><creatorcontrib>Vafa, Mohammad‐Reza</creatorcontrib><creatorcontrib>Heydari, Iraj</creatorcontrib><creatorcontrib>Shojaii, Asieh</creatorcontrib><creatorcontrib>Haqqani, Hamid</creatorcontrib><creatorcontrib>Arablou, Tahereh</creatorcontrib><creatorcontrib>Eghtesadi, Maryam</creatorcontrib><title>Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Diabetes mellitus is the most common metabolic disorder worldwide. This study examined the effect of turmeric supplementation on glycemic status, lipid profile, hs‐CRP and total antioxidant capacity in hyperlipidemic type 2 diabetic patients. In this double‐blind, randomized clinical trial, 80 hyperlipidemic type 2 diabetic patients were divided into turmeric (2,100 mg powdered rhizome of turmeric daily) and placebo groups for 8 weeks. Body weight, fasting plasma glucose, hemoglobin A1c (HbA1c), serum insulin, triglyceride (TG), total cholesterol, low density lypoprotein cholesterol (LDL‐c), high density lypoprotein cholesterol, apolipoprotein A1, apolipoprotein B, high sensitivity C‐reactive protein (hs‐CRP), and total antioxidant capacity were measured before and after intervention. Statistical analysis was carried out using paired and independent t and chi‐square tests. Seventy five patients completed the study. The turmeric group showed significant decreases in body weight, TG, and LDL‐c compared with baseline (p value < 0.05). Body mass index, TG, and total cholesterol decreased significantly in the turmeric group compared with the placebo group (p value < 0.05). No significant changes were observed in other parameters between the two groups after intervention (p value < 0.05). Turmeric improved some fractions of lipid profile and decreased body weight in hyperlipidemic patients with type 2 diabetes. It had no significant effect on glycemic status, hs‐CRP, and total antioxidant capacity in these patients.</description><subject>Antioxidants</subject><subject>Apolipoprotein B</subject><subject>Apolipoproteins</subject><subject>Aquatic plants</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Density</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>glycemic status</subject><subject>Hemoglobin</subject><subject>hs‐CRP</subject><subject>Insulin</subject><subject>lipid profile</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Metabolic disorders</subject><subject>Rhizomes</subject><subject>Statistical analysis</subject><subject>Supplements</subject><subject>total antioxidant capacity</subject><subject>Triglycerides</subject><subject>turmeric</subject><subject>type 2 diabetes</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kdtqFTEUhoNY7LYKPoEEvPFiT11JJnO4lE09QKGlVPAuZJIVmzInkww6dz6C-Ig-ielutSD0aq3Aly8r6yfkBYNjBsDfzCkcV4LxR2TDoG0LJmvxmGyglawoWfP5kDyN8RoAWg7lE3IooJFtVcGG_DpxDk2ik6NpCQMGb-g00i_9anDIfUw6LXFLez97S-cwOd_jll7F3z9-7i7Ot1SPlqYp6T53yU_fvc2VGj1r49NK_Uiv1hnD_v7emPKRcmq97jBhpAP2vc9v0Fknj2OKz8iB033E53f1iHx6d3K5-1Ccnr3_uHt7WhhRtryoKtTgOltjZ1GWtWSuAy11IzjvmqZ1HBqnZe2YROhcbUFUmoOpTMvqRltxRF7fevOvvi4Ykxp8NHkaPeK0RMVZC2UjSs4y-uo_9HpawpinU1yIsmJ59_JeaMIUY0Cn5uAHHVbFQN3kpHJO6ianjL68Ey7dgPYf-DeYDBS3wLe87_VBkTq_vNgL_wBJ_p7r</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Adab, Zohreh</creator><creator>Eghtesadi, Shahryar</creator><creator>Vafa, Mohammad‐Reza</creator><creator>Heydari, Iraj</creator><creator>Shojaii, Asieh</creator><creator>Haqqani, Hamid</creator><creator>Arablou, Tahereh</creator><creator>Eghtesadi, Maryam</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9140-0365</orcidid></search><sort><creationdate>201904</creationdate><title>Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients</title><author>Adab, Zohreh ; Eghtesadi, Shahryar ; Vafa, Mohammad‐Reza ; Heydari, Iraj ; Shojaii, Asieh ; Haqqani, Hamid ; Arablou, Tahereh ; Eghtesadi, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-66ea0fbd7ebde54751fb0a5a8322b889f208fa57f15e0bf7d036a20c6c9178ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antioxidants</topic><topic>Apolipoprotein B</topic><topic>Apolipoproteins</topic><topic>Aquatic plants</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Cholesterol</topic><topic>Clinical trials</topic><topic>Density</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>glycemic status</topic><topic>Hemoglobin</topic><topic>hs‐CRP</topic><topic>Insulin</topic><topic>lipid profile</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Metabolic disorders</topic><topic>Rhizomes</topic><topic>Statistical analysis</topic><topic>Supplements</topic><topic>total antioxidant capacity</topic><topic>Triglycerides</topic><topic>turmeric</topic><topic>type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adab, Zohreh</creatorcontrib><creatorcontrib>Eghtesadi, Shahryar</creatorcontrib><creatorcontrib>Vafa, Mohammad‐Reza</creatorcontrib><creatorcontrib>Heydari, Iraj</creatorcontrib><creatorcontrib>Shojaii, Asieh</creatorcontrib><creatorcontrib>Haqqani, Hamid</creatorcontrib><creatorcontrib>Arablou, Tahereh</creatorcontrib><creatorcontrib>Eghtesadi, Maryam</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adab, Zohreh</au><au>Eghtesadi, Shahryar</au><au>Vafa, Mohammad‐Reza</au><au>Heydari, Iraj</au><au>Shojaii, Asieh</au><au>Haqqani, Hamid</au><au>Arablou, Tahereh</au><au>Eghtesadi, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2019-04</date><risdate>2019</risdate><volume>33</volume><issue>4</issue><spage>1173</spage><epage>1181</epage><pages>1173-1181</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Diabetes mellitus is the most common metabolic disorder worldwide. This study examined the effect of turmeric supplementation on glycemic status, lipid profile, hs‐CRP and total antioxidant capacity in hyperlipidemic type 2 diabetic patients. In this double‐blind, randomized clinical trial, 80 hyperlipidemic type 2 diabetic patients were divided into turmeric (2,100 mg powdered rhizome of turmeric daily) and placebo groups for 8 weeks. Body weight, fasting plasma glucose, hemoglobin A1c (HbA1c), serum insulin, triglyceride (TG), total cholesterol, low density lypoprotein cholesterol (LDL‐c), high density lypoprotein cholesterol, apolipoprotein A1, apolipoprotein B, high sensitivity C‐reactive protein (hs‐CRP), and total antioxidant capacity were measured before and after intervention. Statistical analysis was carried out using paired and independent t and chi‐square tests. Seventy five patients completed the study. The turmeric group showed significant decreases in body weight, TG, and LDL‐c compared with baseline (p value < 0.05). Body mass index, TG, and total cholesterol decreased significantly in the turmeric group compared with the placebo group (p value < 0.05). No significant changes were observed in other parameters between the two groups after intervention (p value < 0.05). Turmeric improved some fractions of lipid profile and decreased body weight in hyperlipidemic patients with type 2 diabetes. It had no significant effect on glycemic status, hs‐CRP, and total antioxidant capacity in these patients.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30859660</pmid><doi>10.1002/ptr.6312</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9140-0365</orcidid></addata></record> |
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| ispartof | Phytotherapy research, 2019-04, Vol.33 (4), p.1173-1181 |
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| subjects | Antioxidants Apolipoprotein B Apolipoproteins Aquatic plants Body mass Body mass index Body size Body weight Cholesterol Clinical trials Density Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) glycemic status Hemoglobin hs‐CRP Insulin lipid profile Lipids Low density lipoprotein Metabolic disorders Rhizomes Statistical analysis Supplements total antioxidant capacity Triglycerides turmeric type 2 diabetes |
| title | Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients |
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