Synthesis and pharmacological evaluation of novel arylpiperazine oxicams derivatives as potent analgesics without ulcerogenicity

[Display omitted] •New arylpiperazine oxicams derivatives were designed and synthesized.•Compounds obtained proved to be between two and five times analgesically more potent than the reference drug piroxicam.•New derivatives did not show any ulcerogenic activity. Gastrotoxicity continues to be a maj...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2019-04, Vol.27 (8), p.1619-1628
Hauptverfasser:	Szczęśniak-Sięga, Berenika M., Mogilski, Szczepan, Wiglusz, Rafał J., Janczak, Jan, Maniewska, Jadwiga, Malinka, Wiesław, Filipek, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Benzothiazine Analgesic activity Analgesics - adverse effects Analgesics - chemistry Analgesics - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Male Mice Models, Molecular Oxicams Piperazines - adverse effects Piperazines - chemistry Piperazines - pharmacology Piroxicam - adverse effects Piroxicam - analogs & derivatives Piroxicam - pharmacology Rats, Wistar Synthesis Ulcer - chemically induced Ulcerogenicity
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