High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells

KRAS mutations are the earliest events found in approximately 90% of pancreatic ductal adenocarcinomas (PDACs). However, little is known as to why KRAS mutations preferentially occur in PDACs and what processes/factors generate these mutations. While abnormal carbohydrate metabolism is associated wi...

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Veröffentlicht in:	Cell metabolism 2019-06, Vol.29 (6), p.1334-1349.e10
Hauptverfasser:	Hu, Chun-Mei, Tien, Sui-Chih, Hsieh, Ping-Kun, Jeng, Yung-Ming, Chang, Ming-Chu, Chang, Yu-Ting, Chen, Yi-Ju, Chen, Yu-Ju, Lee, Eva Y.-H.P., Lee, Wen-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	high glucose KRAS mutation nucleotide imbalance O-GlcNAcylation PFK RNR RRM1
Online-Zugang:	Volltext
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