The process of liver fibrosis in chronic hepatitis C - histological and immunohistochemical study
Liver fibrosis is one of the most serious histopathological (HP) lesions that, together with the inflammatory process and the hepatocyte lesions, determine the change of the liver architecture, having as a clinical result the onset of liver failure phenomena. Hepatitis C virus represents one of the...
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| Veröffentlicht in: | Romanian journal of morphology and embryology 2018, Vol.59 (4), p.1121-1126 |
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| container_title | Romanian journal of morphology and embryology |
| container_volume | 59 |
| creator | Popescu, Nicoleta Laura Predescu, Octavian Ion Badea, Oana Pirici, Ionica Pantiş, Carmen Busuioc, Cristina Jana Cotoi, Bogdan Virgil Mogoantă, Laurenţiu |
| description | Liver fibrosis is one of the most serious histopathological (HP) lesions that, together with the inflammatory process and the hepatocyte lesions, determine the change of the liver architecture, having as a clinical result the onset of liver failure phenomena. Hepatitis C virus represents one of the most frequent conditions leading to the onset of liver fibrosis and favors the progression of the disease towards hepatocellular carcinoma. We evaluated the HP and immunohistochemical (IHC) aspects on fragments of liver biopsies taken from 104 patients diagnosed with chronic hepatitis C and altered capacity of work. In our study, we observed a growth of the portal (Kiernan) spaces by the presence of a chronic inflammatory infiltrate, the presence of collagen fibers and conjunctive matrix. The density and dimensions of collagen fibers were correlated with the severity of the liver disease, in the severe forms being highlighted porto-portal and porto-central fibrous bridges. The IHC examinations highlighted the change of the phenotype of perisinusoidal dendritic cells, the growth of the myofibroblast cells in the portal spaces, the growth of the macrophage number in the inflammatory infiltrate and of the Kupffer cells in the liver parenchyma. |
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Hepatitis C virus represents one of the most frequent conditions leading to the onset of liver fibrosis and favors the progression of the disease towards hepatocellular carcinoma. We evaluated the HP and immunohistochemical (IHC) aspects on fragments of liver biopsies taken from 104 patients diagnosed with chronic hepatitis C and altered capacity of work. In our study, we observed a growth of the portal (Kiernan) spaces by the presence of a chronic inflammatory infiltrate, the presence of collagen fibers and conjunctive matrix. The density and dimensions of collagen fibers were correlated with the severity of the liver disease, in the severe forms being highlighted porto-portal and porto-central fibrous bridges. 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| ispartof | Romanian journal of morphology and embryology, 2018, Vol.59 (4), p.1121-1126 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Dendritic Cells - pathology Hepatitis C, Chronic - complications Hepatitis C, Chronic - pathology Humans Immunohistochemistry Kupffer Cells - pathology Liver Cirrhosis - complications Liver Cirrhosis - pathology Macrophages - pathology Myofibroblasts - pathology |
| title | The process of liver fibrosis in chronic hepatitis C - histological and immunohistochemical study |
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