Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease
Restless legs syndrome (RLS), characterized by leg restlessness and dysesthesia predominantly at night and at rest, disrupts sleep and quality of life. The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clini...
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| Veröffentlicht in: | The American journal of cardiology 2019-05, Vol.123 (10), p.1580-1586 |
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| creator | Yatsu, Shoichiro Kasai, Takatoshi Suda, Shoko Matsumoto, Hiroki Ishiwata, Sayaki Shiroshita, Nanako Kato, Mitsue Kawana, Fusae Murata, Azusa Shimizu, Megumi Shitara, Jun Kato, Takao Hiki, Masaru Sai, Eiryu Miyauchi, Katsumi Daida, Hiroyuki |
| description | Restless legs syndrome (RLS), characterized by leg restlessness and dysesthesia predominantly at night and at rest, disrupts sleep and quality of life. The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clinical significance of RLS in coronary artery disease patients remain unknown. We enrolled coronary artery disease patients who underwent percutaneous coronary intervention. Patients with RLS were identified according to international criteria. Subjective sleepiness, sleep quality, and health-related quality of life were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Short Form-8, respectively. Among 326 patients with coronary artery disease, 26 (8.0%) had RLS. There were no significant differences in characteristics between patients with and without RLS. Sleep quality and quality of life were more disrupted in patients with RLS (Pittsburgh Sleep Quality Index score, 7.4 ± 2.4 vs 5.6 ± 2.5, p |
| doi_str_mv | 10.1016/j.amjcard.2019.02.017 |
| format | Article |
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The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clinical significance of RLS in coronary artery disease patients remain unknown. We enrolled coronary artery disease patients who underwent percutaneous coronary intervention. Patients with RLS were identified according to international criteria. Subjective sleepiness, sleep quality, and health-related quality of life were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Short Form-8, respectively. Among 326 patients with coronary artery disease, 26 (8.0%) had RLS. There were no significant differences in characteristics between patients with and without RLS. Sleep quality and quality of life were more disrupted in patients with RLS (Pittsburgh Sleep Quality Index score, 7.4 ± 2.4 vs 5.6 ± 2.5, p <0.001; physical component summary and mental component summary scores of Short Form-8, 39.6 ± 1.8 vs 43.5 ± 0.5, p = 0.042 and 45.2 ± 8.4 vs 48.4 ± 7.4, p = 0.037, respectively), despite no significant difference in Epworth Sleepiness Scale score (8.2 ± 5.1 vs 7.1 ± 4.8, p = 0.293). In multiple linear regression analyses, RLS was independently associated with Pittsburgh Sleep Quality Index (β = 0.174, p <0.001), physical component summary (β = −0.127, p = 0.029), and mental component summary (β = −0.113, p = 0.042) scores. In conclusion, in patients with coronary artery disease, the prevalence of RLS was relatively high compared to that reported in the general population. The presence of RLS was associated with disrupted sleep quality and health-related quality of life in coronary artery disease patients.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2019.02.017</identifier><identifier>PMID: 30850211</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute coronary syndromes ; Age ; Aged ; Blood pressure ; Body mass index ; Cardiac arrhythmia ; Cardiovascular disease ; Cholesterol ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - complications ; Coronary vessels ; Diabetes ; Female ; Heart diseases ; Heart rate ; Hemoglobin ; Humans ; Hypertension ; Japan - epidemiology ; Kidney diseases ; Leg ; Legs ; Lipoproteins ; Male ; Patients ; Peptides ; Potassium ; Prevalence ; Prospective Studies ; Proteins ; Quality assessment ; Quality of Life ; Regression analysis ; Restless legs syndrome ; Restless Legs Syndrome - diagnosis ; Restless Legs Syndrome - epidemiology ; Restless Legs Syndrome - etiology ; Severity of Illness Index ; Sleep ; Sleep - physiology ; Sleep and wakefulness ; Sleep deprivation ; Sleepiness ; Surveys and Questionnaires</subject><ispartof>The American journal of cardiology, 2019-05, Vol.123 (10), p.1580-1586</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><rights>2019. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-9a0db8adac4b84069a3147074cda7606fc7e86bb907d2d355725e222fca792683</citedby><cites>FETCH-LOGICAL-c393t-9a0db8adac4b84069a3147074cda7606fc7e86bb907d2d355725e222fca792683</cites><orcidid>0000-0003-2588-3797 ; 0000-0001-5747-7668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000291491930222X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30850211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yatsu, Shoichiro</creatorcontrib><creatorcontrib>Kasai, Takatoshi</creatorcontrib><creatorcontrib>Suda, Shoko</creatorcontrib><creatorcontrib>Matsumoto, Hiroki</creatorcontrib><creatorcontrib>Ishiwata, Sayaki</creatorcontrib><creatorcontrib>Shiroshita, Nanako</creatorcontrib><creatorcontrib>Kato, Mitsue</creatorcontrib><creatorcontrib>Kawana, Fusae</creatorcontrib><creatorcontrib>Murata, Azusa</creatorcontrib><creatorcontrib>Shimizu, Megumi</creatorcontrib><creatorcontrib>Shitara, Jun</creatorcontrib><creatorcontrib>Kato, Takao</creatorcontrib><creatorcontrib>Hiki, Masaru</creatorcontrib><creatorcontrib>Sai, Eiryu</creatorcontrib><creatorcontrib>Miyauchi, Katsumi</creatorcontrib><creatorcontrib>Daida, Hiroyuki</creatorcontrib><title>Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Restless legs syndrome (RLS), characterized by leg restlessness and dysesthesia predominantly at night and at rest, disrupts sleep and quality of life. The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clinical significance of RLS in coronary artery disease patients remain unknown. We enrolled coronary artery disease patients who underwent percutaneous coronary intervention. Patients with RLS were identified according to international criteria. Subjective sleepiness, sleep quality, and health-related quality of life were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Short Form-8, respectively. Among 326 patients with coronary artery disease, 26 (8.0%) had RLS. There were no significant differences in characteristics between patients with and without RLS. Sleep quality and quality of life were more disrupted in patients with RLS (Pittsburgh Sleep Quality Index score, 7.4 ± 2.4 vs 5.6 ± 2.5, p <0.001; physical component summary and mental component summary scores of Short Form-8, 39.6 ± 1.8 vs 43.5 ± 0.5, p = 0.042 and 45.2 ± 8.4 vs 48.4 ± 7.4, p = 0.037, respectively), despite no significant difference in Epworth Sleepiness Scale score (8.2 ± 5.1 vs 7.1 ± 4.8, p = 0.293). In multiple linear regression analyses, RLS was independently associated with Pittsburgh Sleep Quality Index (β = 0.174, p <0.001), physical component summary (β = −0.127, p = 0.029), and mental component summary (β = −0.113, p = 0.042) scores. In conclusion, in patients with coronary artery disease, the prevalence of RLS was relatively high compared to that reported in the general population. The presence of RLS was associated with disrupted sleep quality and health-related quality of life in coronary artery disease patients.</description><subject>Acute coronary syndromes</subject><subject>Age</subject><subject>Aged</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Heart rate</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Japan - epidemiology</subject><subject>Kidney diseases</subject><subject>Leg</subject><subject>Legs</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Patients</subject><subject>Peptides</subject><subject>Potassium</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Quality assessment</subject><subject>Quality of Life</subject><subject>Regression analysis</subject><subject>Restless legs syndrome</subject><subject>Restless Legs Syndrome - diagnosis</subject><subject>Restless Legs Syndrome - epidemiology</subject><subject>Restless Legs Syndrome - etiology</subject><subject>Severity of Illness Index</subject><subject>Sleep</subject><subject>Sleep - physiology</subject><subject>Sleep and wakefulness</subject><subject>Sleep deprivation</subject><subject>Sleepiness</subject><subject>Surveys and Questionnaires</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1v1DAQhi0EotvCTwBZ4sIlYezEcXxC1QIFaSUqCuKG5diT4iixi52t1H-PV7tw4MJpNKNnvt6XkBcMagasezPVZpmsSa7mwFQNvAYmH5EN66WqmGLNY7IBAF4p1qozcp7zVFLGRPeUnDXQC-CMbciP64T3ZsZgkZrg6I2_DX701hwKcaRfMK8z5kx3eJvpzUNwKS5IfaDXZvUY1ky_-_Un3cYUg0kP9DKtWMI7n9FkfEaejGbO-PwUL8i3D--_bj9Wu89Xn7aXu8o2qlkrZcANvXHGtkPfQqdMw1oJsrXOyA660Ursu2FQIB13jRCSC-Scj9ZIxbu-uSCvj3PvUvy1LzfrxWeL82wCxn3WnPVKCBBcFfTVP-gU9ymU6zTnRavCcFYocaRsijknHPVd8kt5UDPQBwP0pE8G6IMBGrguBpS-l6fp-2FB97frj-IFeHsEsMhx7zHpbP1BfucT2lW76P-z4jeW9Zhu</recordid><startdate>20190515</startdate><enddate>20190515</enddate><creator>Yatsu, Shoichiro</creator><creator>Kasai, Takatoshi</creator><creator>Suda, Shoko</creator><creator>Matsumoto, Hiroki</creator><creator>Ishiwata, Sayaki</creator><creator>Shiroshita, Nanako</creator><creator>Kato, Mitsue</creator><creator>Kawana, Fusae</creator><creator>Murata, Azusa</creator><creator>Shimizu, Megumi</creator><creator>Shitara, Jun</creator><creator>Kato, Takao</creator><creator>Hiki, Masaru</creator><creator>Sai, Eiryu</creator><creator>Miyauchi, Katsumi</creator><creator>Daida, Hiroyuki</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2588-3797</orcidid><orcidid>https://orcid.org/0000-0001-5747-7668</orcidid></search><sort><creationdate>20190515</creationdate><title>Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease</title><author>Yatsu, Shoichiro ; Kasai, Takatoshi ; Suda, Shoko ; Matsumoto, Hiroki ; Ishiwata, Sayaki ; Shiroshita, Nanako ; Kato, Mitsue ; Kawana, Fusae ; Murata, Azusa ; Shimizu, Megumi ; Shitara, Jun ; Kato, Takao ; Hiki, Masaru ; Sai, Eiryu ; Miyauchi, Katsumi ; Daida, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-9a0db8adac4b84069a3147074cda7606fc7e86bb907d2d355725e222fca792683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute coronary syndromes</topic><topic>Age</topic><topic>Aged</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Heart rate</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Japan - epidemiology</topic><topic>Kidney diseases</topic><topic>Leg</topic><topic>Legs</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Patients</topic><topic>Peptides</topic><topic>Potassium</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Quality assessment</topic><topic>Quality of Life</topic><topic>Regression analysis</topic><topic>Restless legs syndrome</topic><topic>Restless Legs Syndrome - diagnosis</topic><topic>Restless Legs Syndrome - epidemiology</topic><topic>Restless Legs Syndrome - etiology</topic><topic>Severity of Illness Index</topic><topic>Sleep</topic><topic>Sleep - physiology</topic><topic>Sleep and wakefulness</topic><topic>Sleep deprivation</topic><topic>Sleepiness</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yatsu, Shoichiro</creatorcontrib><creatorcontrib>Kasai, Takatoshi</creatorcontrib><creatorcontrib>Suda, Shoko</creatorcontrib><creatorcontrib>Matsumoto, Hiroki</creatorcontrib><creatorcontrib>Ishiwata, Sayaki</creatorcontrib><creatorcontrib>Shiroshita, Nanako</creatorcontrib><creatorcontrib>Kato, Mitsue</creatorcontrib><creatorcontrib>Kawana, Fusae</creatorcontrib><creatorcontrib>Murata, Azusa</creatorcontrib><creatorcontrib>Shimizu, Megumi</creatorcontrib><creatorcontrib>Shitara, Jun</creatorcontrib><creatorcontrib>Kato, Takao</creatorcontrib><creatorcontrib>Hiki, Masaru</creatorcontrib><creatorcontrib>Sai, Eiryu</creatorcontrib><creatorcontrib>Miyauchi, Katsumi</creatorcontrib><creatorcontrib>Daida, Hiroyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yatsu, Shoichiro</au><au>Kasai, Takatoshi</au><au>Suda, Shoko</au><au>Matsumoto, Hiroki</au><au>Ishiwata, Sayaki</au><au>Shiroshita, Nanako</au><au>Kato, Mitsue</au><au>Kawana, Fusae</au><au>Murata, Azusa</au><au>Shimizu, Megumi</au><au>Shitara, Jun</au><au>Kato, Takao</au><au>Hiki, Masaru</au><au>Sai, Eiryu</au><au>Miyauchi, Katsumi</au><au>Daida, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2019-05-15</date><risdate>2019</risdate><volume>123</volume><issue>10</issue><spage>1580</spage><epage>1586</epage><pages>1580-1586</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>Restless legs syndrome (RLS), characterized by leg restlessness and dysesthesia predominantly at night and at rest, disrupts sleep and quality of life. The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clinical significance of RLS in coronary artery disease patients remain unknown. We enrolled coronary artery disease patients who underwent percutaneous coronary intervention. Patients with RLS were identified according to international criteria. Subjective sleepiness, sleep quality, and health-related quality of life were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Short Form-8, respectively. Among 326 patients with coronary artery disease, 26 (8.0%) had RLS. There were no significant differences in characteristics between patients with and without RLS. Sleep quality and quality of life were more disrupted in patients with RLS (Pittsburgh Sleep Quality Index score, 7.4 ± 2.4 vs 5.6 ± 2.5, p <0.001; physical component summary and mental component summary scores of Short Form-8, 39.6 ± 1.8 vs 43.5 ± 0.5, p = 0.042 and 45.2 ± 8.4 vs 48.4 ± 7.4, p = 0.037, respectively), despite no significant difference in Epworth Sleepiness Scale score (8.2 ± 5.1 vs 7.1 ± 4.8, p = 0.293). In multiple linear regression analyses, RLS was independently associated with Pittsburgh Sleep Quality Index (β = 0.174, p <0.001), physical component summary (β = −0.127, p = 0.029), and mental component summary (β = −0.113, p = 0.042) scores. In conclusion, in patients with coronary artery disease, the prevalence of RLS was relatively high compared to that reported in the general population. The presence of RLS was associated with disrupted sleep quality and health-related quality of life in coronary artery disease patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30850211</pmid><doi>10.1016/j.amjcard.2019.02.017</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2588-3797</orcidid><orcidid>https://orcid.org/0000-0001-5747-7668</orcidid></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute coronary syndromes Age Aged Blood pressure Body mass index Cardiac arrhythmia Cardiovascular disease Cholesterol Coronary artery Coronary artery disease Coronary Artery Disease - complications Coronary vessels Diabetes Female Heart diseases Heart rate Hemoglobin Humans Hypertension Japan - epidemiology Kidney diseases Leg Legs Lipoproteins Male Patients Peptides Potassium Prevalence Prospective Studies Proteins Quality assessment Quality of Life Regression analysis Restless legs syndrome Restless Legs Syndrome - diagnosis Restless Legs Syndrome - epidemiology Restless Legs Syndrome - etiology Severity of Illness Index Sleep Sleep - physiology Sleep and wakefulness Sleep deprivation Sleepiness Surveys and Questionnaires |
| title | Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease |
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