Proteasomal inhibition attenuates craniofacial malformations in a zebrafish model of Treacher Collins Syndrome

[Display omitted] Treacher Collins Syndrome (TCS) is a congenital disease characterized by defects in the craniofacial skeleton and absence of mental alterations. Recently we modelled TCS in zebrafish (Danio rerio) embryos through the microinjection of Morpholino® oligonucleotides blocking the trans...

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Veröffentlicht in:	Biochemical pharmacology 2019-05, Vol.163, p.362-370
Hauptverfasser:	Rosas, Mauco Gil, Lorenzatti, Agustín, Porcel de Peralta, Mauro S., Calcaterra, Nora B., Coux, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bortezomib Cnbp Embryo, Nonmammalian - abnormalities Embryo, Nonmammalian - drug effects Gene Expression Regulation, Developmental - drug effects Gene Knockdown Techniques Mandibulofacial Dysostosis - metabolism Mandibulofacial Dysostosis - pathology Morpholinos - adverse effects Neurocristopathies Phosphoproteins - genetics Phosphoproteins - metabolism Ribosomopathies RNA-Binding Proteins - metabolism Treacle Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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