DNA minor groove binding of a well known anti-mycobacterial drug dapsone: A spectroscopic, viscometric and molecular docking study

Dapsone is a sulfone drug mainly used as anti-microbial and anti-inflammatory agent for the treatment of various diseases including leprosy. Recently, its interaction with protein (bovine serum albumin) is evidenced. But, the binding propensity of this anti-mycobacterial drug towards DNA is still un...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2019-04, Vol.665, p.107-113
Hauptverfasser:	Chakraborty, Ayon, Panda, Alok Kumar, Ghosh, Rajesh, Biswas, Ashis
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemistry Binding Sites Circular Dichroism Dapsone Dapsone - chemistry DNA - chemistry Drug-DNA interaction Groove binding Molecular docking Molecular Docking Simulation Nucleic Acid Denaturation Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Spectroscopy
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