Direct Access to Acyl Fluorides from Carboxylic Acids Using a Phosphine/Fluoride Deoxyfluorination Reagent System

A fast and simple method for deoxyfluorination of carboxylic acids is presented. The protocol employs commodity chemicals (PPh3, NBS, fluoride), affording products in excellent yields under mild conditions. Acyloxyphosphonium ion, the key reaction intermediate, was identified by NMR spectroscopic me...

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Veröffentlicht in:	Organic letters 2019-03, Vol.21 (6), p.1659-1663
Hauptverfasser:	Munoz, Socrates B, Dang, Huong, Ispizua-Rodriguez, Xanath, Mathew, Thomas, Prakash, G. K. Surya
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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