Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma
Background: Epidemiologic studies have demonstrated an increased risk for papillary thyroid carcinoma (PTC) with increasing body mass index (BMI). However, the relationships between excess weight and the behavior of PTC are inconsistent. The aim of this study was to evaluate the impact of excess wei...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2019-07, Vol.128 (7), p.625-632 |
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| creator | Feng, Jia-Wei Yang, Xing-Hai Wu, Bao-Qiang Sun, Dong-Lin Jiang, Yong Qu, Zhen |
| description | Background:
Epidemiologic studies have demonstrated an increased risk for papillary thyroid carcinoma (PTC) with increasing body mass index (BMI). However, the relationships between excess weight and the behavior of PTC are inconsistent. The aim of this study was to evaluate the impact of excess weight on clinicopathologic features of PTC and on patient outcomes.
Methods:
Data from 417 patients with PTC who underwent total thyroidectomy with cervical lymph node dissection were retrospectively analyzed. On the basis of World Health Organization standardized categories of BMI, patients were divided into 4 groups: underweight, normal weight, overweight, and obese. Histopathologic tumor features, stage at diagnosis, and disease status were determined by chart review. Logistic regression models were used to define associations between BMI and clinicopathologic features of PTC. Cox proportional-hazards models were used to assess associations between BMI and locoregional recurrence.
Results:
Overweight (odds ratio [OR], 3.90; P = .040) and obesity (OR, 9.19; P = .012) were independent predictors of vascular invasion. Furthermore, obesity (OR, 6.14; P = .004) was an independent predictor of extrathyroidal invasion. During follow-up (median, 29 months; range, 5-87 months), 48 patients (11.5%) experienced locoregional recurrence. There were no significant differences in locoregional recurrence of PTC among BMI groups. When adjusted for other confounding factors, extrathyroidal invasion (OR, 8.35; P < .001), vascular invasion (OR, 3.57; P < .001), cervical lymph node metastasis (OR, 3.71; P = .009), and advanced tumor-node-metastasis stage (OR, 3.81; P < .001) were identified as independent factors for locoregional recurrence.
Conclusions:
Higher BMI was associated with extrathyroidal invasion and vascular invasion in patients with PTC, which suggests that excess weight is associated with aggressive clinicopathologic features of PTC. But patients with higher BMI did not have an increased risk for developing postoperative complications and locoregional recurrence. |
| doi_str_mv | 10.1177/0003489419834314 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2188981619</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0003489419834314</sage_id><sourcerecordid>2188981619</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-fa27816ce9ff890876704074ac65d4e2cf6d3881cd5f7dba99f01bb48e2028993</originalsourceid><addsrcrecordid>eNp1UM9LwzAUDqK4Ob17khy9VJMmbZKjFqeDiR4meJGSpsmW0TY1acH997ZsehA8PR7fj_e9D4BLjG4wZuwWIUQoFxQLTijB9AhMsaAkSlj8fgymIxyN-ASchbAdVpqg-BRMCOIUM0ym4GPRmKrXjdLQGXjvyh18liHARVPqL-ga2G00zCrbWOVa2W1c5dZWwbmWXe91GEWvsrVVJf0OrjY772wJM-mVbVwtz8GJkVXQF4c5A2_zh1X2FC1fHhfZ3TJShLAuMjJmHKdKC2O4QJylDFHEqFRpUlIdK5OWhHOsysSwspBCGISLgnIdo5gLQWbgeu_bevfZ69DltQ1KD6ka7fqQx5hzMVzAIxXtqcq7ELw2eettPaTPMcrHUvO_pQ6Sq4N7X9S6_BX8tDgQoj0hyLXOt673zfDt_4bf8cx-Vg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2188981619</pqid></control><display><type>article</type><title>Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Feng, Jia-Wei ; Yang, Xing-Hai ; Wu, Bao-Qiang ; Sun, Dong-Lin ; Jiang, Yong ; Qu, Zhen</creator><creatorcontrib>Feng, Jia-Wei ; Yang, Xing-Hai ; Wu, Bao-Qiang ; Sun, Dong-Lin ; Jiang, Yong ; Qu, Zhen</creatorcontrib><description>Background:
Epidemiologic studies have demonstrated an increased risk for papillary thyroid carcinoma (PTC) with increasing body mass index (BMI). However, the relationships between excess weight and the behavior of PTC are inconsistent. The aim of this study was to evaluate the impact of excess weight on clinicopathologic features of PTC and on patient outcomes.
Methods:
Data from 417 patients with PTC who underwent total thyroidectomy with cervical lymph node dissection were retrospectively analyzed. On the basis of World Health Organization standardized categories of BMI, patients were divided into 4 groups: underweight, normal weight, overweight, and obese. Histopathologic tumor features, stage at diagnosis, and disease status were determined by chart review. Logistic regression models were used to define associations between BMI and clinicopathologic features of PTC. Cox proportional-hazards models were used to assess associations between BMI and locoregional recurrence.
Results:
Overweight (odds ratio [OR], 3.90; P = .040) and obesity (OR, 9.19; P = .012) were independent predictors of vascular invasion. Furthermore, obesity (OR, 6.14; P = .004) was an independent predictor of extrathyroidal invasion. During follow-up (median, 29 months; range, 5-87 months), 48 patients (11.5%) experienced locoregional recurrence. There were no significant differences in locoregional recurrence of PTC among BMI groups. When adjusted for other confounding factors, extrathyroidal invasion (OR, 8.35; P < .001), vascular invasion (OR, 3.57; P < .001), cervical lymph node metastasis (OR, 3.71; P = .009), and advanced tumor-node-metastasis stage (OR, 3.81; P < .001) were identified as independent factors for locoregional recurrence.
Conclusions:
Higher BMI was associated with extrathyroidal invasion and vascular invasion in patients with PTC, which suggests that excess weight is associated with aggressive clinicopathologic features of PTC. But patients with higher BMI did not have an increased risk for developing postoperative complications and locoregional recurrence.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/0003489419834314</identifier><identifier>PMID: 30841713</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Blood Vessels - pathology ; Body Mass Index ; Comorbidity ; Female ; Humans ; Logistic Models ; Lymph Nodes - pathology ; Male ; Middle Aged ; Neck Dissection ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Staging ; Obesity - epidemiology ; Odds Ratio ; Overweight - epidemiology ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Thinness - epidemiology ; Thyroid Cancer, Papillary - epidemiology ; Thyroid Cancer, Papillary - pathology ; Thyroid Cancer, Papillary - surgery ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy</subject><ispartof>Annals of otology, rhinology & laryngology, 2019-07, Vol.128 (7), p.625-632</ispartof><rights>The Author(s) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-fa27816ce9ff890876704074ac65d4e2cf6d3881cd5f7dba99f01bb48e2028993</citedby><cites>FETCH-LOGICAL-c337t-fa27816ce9ff890876704074ac65d4e2cf6d3881cd5f7dba99f01bb48e2028993</cites><orcidid>0000-0003-2502-1353</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0003489419834314$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0003489419834314$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30841713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Jia-Wei</creatorcontrib><creatorcontrib>Yang, Xing-Hai</creatorcontrib><creatorcontrib>Wu, Bao-Qiang</creatorcontrib><creatorcontrib>Sun, Dong-Lin</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><creatorcontrib>Qu, Zhen</creatorcontrib><title>Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>Background:
Epidemiologic studies have demonstrated an increased risk for papillary thyroid carcinoma (PTC) with increasing body mass index (BMI). However, the relationships between excess weight and the behavior of PTC are inconsistent. The aim of this study was to evaluate the impact of excess weight on clinicopathologic features of PTC and on patient outcomes.
Methods:
Data from 417 patients with PTC who underwent total thyroidectomy with cervical lymph node dissection were retrospectively analyzed. On the basis of World Health Organization standardized categories of BMI, patients were divided into 4 groups: underweight, normal weight, overweight, and obese. Histopathologic tumor features, stage at diagnosis, and disease status were determined by chart review. Logistic regression models were used to define associations between BMI and clinicopathologic features of PTC. Cox proportional-hazards models were used to assess associations between BMI and locoregional recurrence.
Results:
Overweight (odds ratio [OR], 3.90; P = .040) and obesity (OR, 9.19; P = .012) were independent predictors of vascular invasion. Furthermore, obesity (OR, 6.14; P = .004) was an independent predictor of extrathyroidal invasion. During follow-up (median, 29 months; range, 5-87 months), 48 patients (11.5%) experienced locoregional recurrence. There were no significant differences in locoregional recurrence of PTC among BMI groups. When adjusted for other confounding factors, extrathyroidal invasion (OR, 8.35; P < .001), vascular invasion (OR, 3.57; P < .001), cervical lymph node metastasis (OR, 3.71; P = .009), and advanced tumor-node-metastasis stage (OR, 3.81; P < .001) were identified as independent factors for locoregional recurrence.
Conclusions:
Higher BMI was associated with extrathyroidal invasion and vascular invasion in patients with PTC, which suggests that excess weight is associated with aggressive clinicopathologic features of PTC. But patients with higher BMI did not have an increased risk for developing postoperative complications and locoregional recurrence.</description><subject>Adult</subject><subject>Blood Vessels - pathology</subject><subject>Body Mass Index</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neck Dissection</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Staging</subject><subject>Obesity - epidemiology</subject><subject>Odds Ratio</subject><subject>Overweight - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Thinness - epidemiology</subject><subject>Thyroid Cancer, Papillary - epidemiology</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Cancer, Papillary - surgery</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UM9LwzAUDqK4Ob17khy9VJMmbZKjFqeDiR4meJGSpsmW0TY1acH997ZsehA8PR7fj_e9D4BLjG4wZuwWIUQoFxQLTijB9AhMsaAkSlj8fgymIxyN-ASchbAdVpqg-BRMCOIUM0ym4GPRmKrXjdLQGXjvyh18liHARVPqL-ga2G00zCrbWOVa2W1c5dZWwbmWXe91GEWvsrVVJf0OrjY772wJM-mVbVwtz8GJkVXQF4c5A2_zh1X2FC1fHhfZ3TJShLAuMjJmHKdKC2O4QJylDFHEqFRpUlIdK5OWhHOsysSwspBCGISLgnIdo5gLQWbgeu_bevfZ69DltQ1KD6ka7fqQx5hzMVzAIxXtqcq7ELw2eettPaTPMcrHUvO_pQ6Sq4N7X9S6_BX8tDgQoj0hyLXOt673zfDt_4bf8cx-Vg</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Feng, Jia-Wei</creator><creator>Yang, Xing-Hai</creator><creator>Wu, Bao-Qiang</creator><creator>Sun, Dong-Lin</creator><creator>Jiang, Yong</creator><creator>Qu, Zhen</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2502-1353</orcidid></search><sort><creationdate>201907</creationdate><title>Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma</title><author>Feng, Jia-Wei ; Yang, Xing-Hai ; Wu, Bao-Qiang ; Sun, Dong-Lin ; Jiang, Yong ; Qu, Zhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-fa27816ce9ff890876704074ac65d4e2cf6d3881cd5f7dba99f01bb48e2028993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Blood Vessels - pathology</topic><topic>Body Mass Index</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Lymph Nodes - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neck Dissection</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Staging</topic><topic>Obesity - epidemiology</topic><topic>Odds Ratio</topic><topic>Overweight - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Thinness - epidemiology</topic><topic>Thyroid Cancer, Papillary - epidemiology</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Cancer, Papillary - surgery</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Jia-Wei</creatorcontrib><creatorcontrib>Yang, Xing-Hai</creatorcontrib><creatorcontrib>Wu, Bao-Qiang</creatorcontrib><creatorcontrib>Sun, Dong-Lin</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><creatorcontrib>Qu, Zhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Jia-Wei</au><au>Yang, Xing-Hai</au><au>Wu, Bao-Qiang</au><au>Sun, Dong-Lin</au><au>Jiang, Yong</au><au>Qu, Zhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2019-07</date><risdate>2019</risdate><volume>128</volume><issue>7</issue><spage>625</spage><epage>632</epage><pages>625-632</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><abstract>Background:
Epidemiologic studies have demonstrated an increased risk for papillary thyroid carcinoma (PTC) with increasing body mass index (BMI). However, the relationships between excess weight and the behavior of PTC are inconsistent. The aim of this study was to evaluate the impact of excess weight on clinicopathologic features of PTC and on patient outcomes.
Methods:
Data from 417 patients with PTC who underwent total thyroidectomy with cervical lymph node dissection were retrospectively analyzed. On the basis of World Health Organization standardized categories of BMI, patients were divided into 4 groups: underweight, normal weight, overweight, and obese. Histopathologic tumor features, stage at diagnosis, and disease status were determined by chart review. Logistic regression models were used to define associations between BMI and clinicopathologic features of PTC. Cox proportional-hazards models were used to assess associations between BMI and locoregional recurrence.
Results:
Overweight (odds ratio [OR], 3.90; P = .040) and obesity (OR, 9.19; P = .012) were independent predictors of vascular invasion. Furthermore, obesity (OR, 6.14; P = .004) was an independent predictor of extrathyroidal invasion. During follow-up (median, 29 months; range, 5-87 months), 48 patients (11.5%) experienced locoregional recurrence. There were no significant differences in locoregional recurrence of PTC among BMI groups. When adjusted for other confounding factors, extrathyroidal invasion (OR, 8.35; P < .001), vascular invasion (OR, 3.57; P < .001), cervical lymph node metastasis (OR, 3.71; P = .009), and advanced tumor-node-metastasis stage (OR, 3.81; P < .001) were identified as independent factors for locoregional recurrence.
Conclusions:
Higher BMI was associated with extrathyroidal invasion and vascular invasion in patients with PTC, which suggests that excess weight is associated with aggressive clinicopathologic features of PTC. But patients with higher BMI did not have an increased risk for developing postoperative complications and locoregional recurrence.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>30841713</pmid><doi>10.1177/0003489419834314</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2502-1353</orcidid></addata></record> |
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| ispartof | Annals of otology, rhinology & laryngology, 2019-07, Vol.128 (7), p.625-632 |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adult Blood Vessels - pathology Body Mass Index Comorbidity Female Humans Logistic Models Lymph Nodes - pathology Male Middle Aged Neck Dissection Neoplasm Invasiveness Neoplasm Recurrence, Local - epidemiology Neoplasm Staging Obesity - epidemiology Odds Ratio Overweight - epidemiology Proportional Hazards Models Retrospective Studies Risk Factors Thinness - epidemiology Thyroid Cancer, Papillary - epidemiology Thyroid Cancer, Papillary - pathology Thyroid Cancer, Papillary - surgery Thyroid Neoplasms - epidemiology Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy |
| title | Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma |
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