Activation of constitutive androstane receptor inhibits intestinal CFTR-mediated chloride transport

[Display omitted] •In intestine, CAR involves in the process of xenobiotic metabolism by regulating the expression of ABC transporters.•Finding illustrate a novel role of CAR in the regulation of intestinal CFTR-mediated chloride secretion.•Activation of CAR decreases intestinal CFTR expression at t...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-03, Vol.111, p.1249-1259
Hauptverfasser:	Kittayaruksakul, Suticha, Sawasvirojwong, Sutthipong, Noitem, Rattikarn, Pongkorpsakol, Pawin, Muanprasat, Chatchai, Chatsudthipong, Varanuj
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstane receptor Animals Cell Line Cell Membrane - metabolism Chloride channels Chlorides - metabolism Cyclic AMP - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Diarrhea Diarrhea - metabolism Down-Regulation - physiology Electrolyte transport Epithelial Cells - metabolism Humans Intestinal Mucosa - metabolism Intestines Mice Mice, Inbred ICR Nuclear receptor Permeability Receptors, Cytoplasmic and Nuclear - metabolism RNA, Messenger - metabolism
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