Strain-Release-Driven Homologation of Boronic Esters: Application to the Modular Synthesis of Azetidines

Azetidines are important motifs in medicinal chemistry, but there are a limited number of methods for their synthesis. Herein, we present a new method for their modular construction by exploiting the high ring strain associated with azabicyclo[1.1.0]­butane. Generation of azabicyclo[1.1.0]­butyl lit...

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Veröffentlicht in:	Journal of the American Chemical Society 2019-03, Vol.141 (11), p.4573-4578
Hauptverfasser:	Fawcett, Alexander, Murtaza, Amna, Gregson, Charlotte H. U, Aggarwal, Varinder K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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