Positive selection of cereblon modified function including its E3 ubiquitin ligase activity and binding efficiency with AMPK

[Display omitted] •Cys366 residue at substrate binding domain of CRBN was under positive selection.•Auto-ubiquitination activity of CRBN increased by introducing C366S mutation.•C366S CRBN has higher binding affinity with AMPKα.•Mirror tree method suggested coevolution of CRBN and AMPKα. Cereblon (C...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular phylogenetics and evolution 2019-06, Vol.135, p.78-85
Hauptverfasser:	Onodera, Wataru, Asahi, Toru, Sawamura, Naoya
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPK Cereblon dN/dS E3 ubiquitin ligase Positive selection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!