Molluscicidal activity of cardiac glycosides isolated from Adenium obesum
BACKGROUND Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum. RESULTS The benzene‐soluble fraction o...
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| Veröffentlicht in: | Pest management science 2019-10, Vol.75 (10), p.2770-2775 |
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| creator | Alzabib, Ali A Abobakr, Yasser Al‐Sarar, Ali S Hussein, Hamdy I Basudan, Omer A El‐Gamal, Ali A Abdel‐Kader, Maged S El_Komy, Mahmoud H |
| description | BACKGROUND
Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum.
RESULTS
The benzene‐soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 µg g−1 body weight (bw). The bioactivity‐guided chemical exploration of the benzene‐soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 µg g−1 bw, respectively.
CONCLUSION
Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time. © 2019 Society of Chemical Industry
This is the first report on the molluscicidal activity of two cardiac glycoside, cerberin and neriifolin, isolated from Adenium obesum against the terrestrial snail Monacha obstructa. |
| doi_str_mv | 10.1002/ps.5388 |
| format | Article |
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Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum.
RESULTS
The benzene‐soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 µg g−1 body weight (bw). The bioactivity‐guided chemical exploration of the benzene‐soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 µg g−1 bw, respectively.
CONCLUSION
Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time. © 2019 Society of Chemical Industry
This is the first report on the molluscicidal activity of two cardiac glycoside, cerberin and neriifolin, isolated from Adenium obesum against the terrestrial snail Monacha obstructa.</description><identifier>ISSN: 1526-498X</identifier><identifier>EISSN: 1526-4998</identifier><identifier>DOI: 10.1002/ps.5388</identifier><identifier>PMID: 30838743</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adenium obesum ; Agrochemicals ; Animals ; Apocynaceae - chemistry ; Benzene ; Biological activity ; Body weight ; Cardenolides - pharmacology ; Cardiac glycosides ; Cardiac Glycosides - pharmacology ; cerberin ; Glycosides ; Hydrocarbons ; Lethal dose ; Lethal Dose 50 ; Molluscacides - pharmacology ; molluscicidal activity ; Mollusks ; neriifolin ; Organic chemistry ; Pesticides ; Pests ; Plant Extracts - pharmacology ; Plant Stems - chemistry ; Snails ; Snails - drug effects ; Terrestrial environments</subject><ispartof>Pest management science, 2019-10, Vol.75 (10), p.2770-2775</ispartof><rights>2019 Society of Chemical Industry</rights><rights>2019 Society of Chemical Industry.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3458-29f3fcce38b872c458aab84f172281f7bc8491cac0be9a43e78f157593aac4053</citedby><cites>FETCH-LOGICAL-c3458-29f3fcce38b872c458aab84f172281f7bc8491cac0be9a43e78f157593aac4053</cites><orcidid>0000-0002-2760-1477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fps.5388$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fps.5388$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30838743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alzabib, Ali A</creatorcontrib><creatorcontrib>Abobakr, Yasser</creatorcontrib><creatorcontrib>Al‐Sarar, Ali S</creatorcontrib><creatorcontrib>Hussein, Hamdy I</creatorcontrib><creatorcontrib>Basudan, Omer A</creatorcontrib><creatorcontrib>El‐Gamal, Ali A</creatorcontrib><creatorcontrib>Abdel‐Kader, Maged S</creatorcontrib><creatorcontrib>El_Komy, Mahmoud H</creatorcontrib><title>Molluscicidal activity of cardiac glycosides isolated from Adenium obesum</title><title>Pest management science</title><addtitle>Pest Manag Sci</addtitle><description>BACKGROUND
Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum.
RESULTS
The benzene‐soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 µg g−1 body weight (bw). The bioactivity‐guided chemical exploration of the benzene‐soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 µg g−1 bw, respectively.
CONCLUSION
Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time. © 2019 Society of Chemical Industry
This is the first report on the molluscicidal activity of two cardiac glycoside, cerberin and neriifolin, isolated from Adenium obesum against the terrestrial snail Monacha obstructa.</description><subject>Adenium obesum</subject><subject>Agrochemicals</subject><subject>Animals</subject><subject>Apocynaceae - chemistry</subject><subject>Benzene</subject><subject>Biological activity</subject><subject>Body weight</subject><subject>Cardenolides - pharmacology</subject><subject>Cardiac glycosides</subject><subject>Cardiac Glycosides - pharmacology</subject><subject>cerberin</subject><subject>Glycosides</subject><subject>Hydrocarbons</subject><subject>Lethal dose</subject><subject>Lethal Dose 50</subject><subject>Molluscacides - pharmacology</subject><subject>molluscicidal activity</subject><subject>Mollusks</subject><subject>neriifolin</subject><subject>Organic chemistry</subject><subject>Pesticides</subject><subject>Pests</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Stems - chemistry</subject><subject>Snails</subject><subject>Snails - drug effects</subject><subject>Terrestrial environments</subject><issn>1526-498X</issn><issn>1526-4998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMoTqv4DyTghYJ0Jk1rTy7H8GMwUVDBu5CmiWSkS21apf_ezs1dCJ6Lc0J4eM7hReiEkjElJLmqwzhjADvogGbJdZxyDrvbN7yN0GEIC0II5zzZRyNGgEGesgM0e_DOdUFZZUvpsFSt_bRtj73BSjallQq_u175YEsdsA3eyVaX2DS-wpNSL21XYV_o0FVHaM9IF_TxZkbo9fbmZXofzx_vZtPJPFYszSBOuGFGKc2ggDxRw5eUBaSG5kkC1OSFgpRTJRUpNJcp0zkYmuUZZ1KqlGQsQhdrb934j06HVlQ2KO2cXGrfBZFQgAxyNlSEzv6gC981y-E6MSzLOQM2tAidrynV-BAabUTd2Eo2vaBErNIVdRCrdAfydOPrikqXW-43zgG4XANf1un-P494ev7RfQOOHIH8</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Alzabib, Ali A</creator><creator>Abobakr, Yasser</creator><creator>Al‐Sarar, Ali S</creator><creator>Hussein, Hamdy I</creator><creator>Basudan, Omer A</creator><creator>El‐Gamal, Ali A</creator><creator>Abdel‐Kader, Maged S</creator><creator>El_Komy, Mahmoud H</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2760-1477</orcidid></search><sort><creationdate>201910</creationdate><title>Molluscicidal activity of cardiac glycosides isolated from Adenium obesum</title><author>Alzabib, Ali A ; Abobakr, Yasser ; Al‐Sarar, Ali S ; Hussein, Hamdy I ; Basudan, Omer A ; El‐Gamal, Ali A ; Abdel‐Kader, Maged S ; El_Komy, Mahmoud H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3458-29f3fcce38b872c458aab84f172281f7bc8491cac0be9a43e78f157593aac4053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenium obesum</topic><topic>Agrochemicals</topic><topic>Animals</topic><topic>Apocynaceae - chemistry</topic><topic>Benzene</topic><topic>Biological activity</topic><topic>Body weight</topic><topic>Cardenolides - pharmacology</topic><topic>Cardiac glycosides</topic><topic>Cardiac Glycosides - pharmacology</topic><topic>cerberin</topic><topic>Glycosides</topic><topic>Hydrocarbons</topic><topic>Lethal dose</topic><topic>Lethal Dose 50</topic><topic>Molluscacides - pharmacology</topic><topic>molluscicidal activity</topic><topic>Mollusks</topic><topic>neriifolin</topic><topic>Organic chemistry</topic><topic>Pesticides</topic><topic>Pests</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Stems - chemistry</topic><topic>Snails</topic><topic>Snails - drug effects</topic><topic>Terrestrial environments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alzabib, Ali A</creatorcontrib><creatorcontrib>Abobakr, Yasser</creatorcontrib><creatorcontrib>Al‐Sarar, Ali S</creatorcontrib><creatorcontrib>Hussein, Hamdy I</creatorcontrib><creatorcontrib>Basudan, Omer A</creatorcontrib><creatorcontrib>El‐Gamal, Ali A</creatorcontrib><creatorcontrib>Abdel‐Kader, Maged S</creatorcontrib><creatorcontrib>El_Komy, Mahmoud H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pest management science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alzabib, Ali A</au><au>Abobakr, Yasser</au><au>Al‐Sarar, Ali S</au><au>Hussein, Hamdy I</au><au>Basudan, Omer A</au><au>El‐Gamal, Ali A</au><au>Abdel‐Kader, Maged S</au><au>El_Komy, Mahmoud H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molluscicidal activity of cardiac glycosides isolated from Adenium obesum</atitle><jtitle>Pest management science</jtitle><addtitle>Pest Manag Sci</addtitle><date>2019-10</date><risdate>2019</risdate><volume>75</volume><issue>10</issue><spage>2770</spage><epage>2775</epage><pages>2770-2775</pages><issn>1526-498X</issn><eissn>1526-4998</eissn><abstract>BACKGROUND
Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum.
RESULTS
The benzene‐soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 µg g−1 body weight (bw). The bioactivity‐guided chemical exploration of the benzene‐soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 µg g−1 bw, respectively.
CONCLUSION
Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time. © 2019 Society of Chemical Industry
This is the first report on the molluscicidal activity of two cardiac glycoside, cerberin and neriifolin, isolated from Adenium obesum against the terrestrial snail Monacha obstructa.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>30838743</pmid><doi>10.1002/ps.5388</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2760-1477</orcidid></addata></record> |
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| ispartof | Pest management science, 2019-10, Vol.75 (10), p.2770-2775 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adenium obesum Agrochemicals Animals Apocynaceae - chemistry Benzene Biological activity Body weight Cardenolides - pharmacology Cardiac glycosides Cardiac Glycosides - pharmacology cerberin Glycosides Hydrocarbons Lethal dose Lethal Dose 50 Molluscacides - pharmacology molluscicidal activity Mollusks neriifolin Organic chemistry Pesticides Pests Plant Extracts - pharmacology Plant Stems - chemistry Snails Snails - drug effects Terrestrial environments |
| title | Molluscicidal activity of cardiac glycosides isolated from Adenium obesum |
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