Low Sensitivity of Fecal Immunochemical Tests and Blood-Based Markers of DNA Hypermethylation for Detection of Sessile Serrated Adenomas/Polyps

Background Early detection and removal of precursor lesions reduce colorectal cancer morbidity and mortality. Sessile serrated adenomas/polyps (SSP) are a recognized precursor of cancer, but there are limited studies on whether current screening techniques detect this pathology. Aims To investigate...

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Veröffentlicht in:	Digestive diseases and sciences 2019-09, Vol.64 (9), p.2555-2562
Hauptverfasser:	Cock, Charles, Anwar, Shahzaib, Byrne, Susan E., Meng, Rosie, Pedersen, Susanne, Fraser, Robert J. L., Young, Graeme P., Symonds, Erin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - blood Adenoma - diagnosis Adenoma - pathology Adult Aged Aged, 80 and over Analysis Biochemistry Biomarkers, Tumor - blood Blood Blood tests Cancer Colonic Neoplasms - blood Colonic Neoplasms - diagnosis Colonic Neoplasms - pathology Colonic Polyps - blood Colonic Polyps - diagnosis Colonic Polyps - pathology Colonoscopy Colorectal cancer DNA DNA Methylation Early Detection of Cancer - methods Epigenetic inheritance Feces Female Gastroenterology Health aspects Hemoglobin Hemoglobins - analysis Hepatology Humans Ikaros Transcription Factor - blood Ikaros Transcription Factor - genetics Immunochemistry Male Medical examination Medical screening Medicine Medicine & Public Health Middle Aged Mortality Occult Blood Oncology Oncology, Experimental Original Article Pathology Prospective Studies Sensitivity and Specificity Transaminases - blood Transaminases - genetics Transplant Surgery Tumors
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