Chitosan-graft-poly(methyl methacrylate) amphiphilic nanoparticles: Self-association and physicochemical characterization
•We report on the self-assembly of a chitosan-poly(methyl methacrylate) copolymer.•Self-assembly forms water-swollen nanoparticles with Dh of 150–200 nm.•Sodium tripolyphosphate crosslinking reduces the nanoparticle size.•Sodium tripolyphosphate crosslinking increases the nanoparticle density.•SANS...
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| Veröffentlicht in: | Carbohydrate polymers 2019-05, Vol.212, p.412-420 |
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| container_title | Carbohydrate polymers |
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| creator | Schlachet, Inbar Trousil, Jiří Rak, Dmytro Knudsen, Kenneth D. Pavlova, Ewa Nyström, Bo Sosnik, Alejandro |
| description | •We report on the self-assembly of a chitosan-poly(methyl methacrylate) copolymer.•Self-assembly forms water-swollen nanoparticles with Dh of 150–200 nm.•Sodium tripolyphosphate crosslinking reduces the nanoparticle size.•Sodium tripolyphosphate crosslinking increases the nanoparticle density.•SANS and TEM analyses indicate the formation of multi-micellar nanoparticles.
In this work, we synthesized and characterized the self-assembly behavior of a chitosan-poly(methyl methacrylate) graft copolymer and the properties of the formed nanoparticles by static and dynamic light scattering, small-angle neutron scattering, and transmission electron microscopy. Overall, our results indicate that the hydrophobization of the chitosan side-chain with PMMA leads to a complex array of small unimolecular and/or small-aggregation number “building blocks” that further self-assemble into larger amphiphilic nanoparticles. |
| doi_str_mv | 10.1016/j.carbpol.2019.02.022 |
| format | Article |
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| language | eng |
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| subjects | Amphiphilic polymeric nanoparticles Chitosan-graft-poly(methyl methacrylate) copolymers Self-assembly Small-angle neutron scattering (SANS) Static light scattering (SLS) and dynamic light scattering (DLS) |
| title | Chitosan-graft-poly(methyl methacrylate) amphiphilic nanoparticles: Self-association and physicochemical characterization |
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