Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer

Inflammatory breast cancer (IBC) is a highly metastatic, lethal form of breast cancer that lacks targeted therapeutic strategies. Inspired by the promising cytotoxicity of gambogic acid and related caged xanthones in spheroidsMARY-X, an in vitro preclinical IBC model, we constructed a library of syn...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-04, Vol.168, p.405-413
Hauptverfasser:	Chantarasriwong, Oraphin, Milcarek, Andrew T., Morales, Theodore Habarth, Settle, Aspen L., Rezende, Celso O., Althufairi, Bashayer D., Theodoraki, Maria A., Alpaugh, Mary L., Theodorakis, Emmanuel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast cancer Natural product Spheroids Synthetic methods
Online-Zugang:	Volltext
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