Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice

The aim of this study is to explore the macroscale neural mechanisms of the antidepressant effects of Xiaoyaosan, a traditional Chinese herbal formula. We analyzed blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOL...

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Veröffentlicht in:	Neuropathology 2019-04, Vol.39 (2), p.85-96
Hauptverfasser:	Bi, Yanmeng, Huang, Peng, Dong, Zhaoyang, Gao, Tingting, Huang, Shaohui, Gao, Lei, Lv, Zhiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antidepressants Antidepressive Agents - administration & dosage Brain - drug effects Brain - physiopathology Brain Mapping depression Depression - drug therapy Depression - physiopathology Disease Models, Animal Drugs, Chinese Herbal - administration & dosage fMRI Functional magnetic resonance imaging Herbal medicine hippocampus Magnetic Resonance Imaging Male Mental depression Mice, Inbred C57BL MXYS Neural networks Neuroimaging regional homogeneity
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