Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice
The aim of this study is to explore the macroscale neural mechanisms of the antidepressant effects of Xiaoyaosan, a traditional Chinese herbal formula. We analyzed blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOL...
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| Veröffentlicht in: | Neuropathology 2019-04, Vol.39 (2), p.85-96 |
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| creator | Bi, Yanmeng Huang, Peng Dong, Zhaoyang Gao, Tingting Huang, Shaohui Gao, Lei Lv, Zhiping |
| description | The aim of this study is to explore the macroscale neural mechanisms of the antidepressant effects of Xiaoyaosan, a traditional Chinese herbal formula. We analyzed blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOLD signals and analyze the intra‐region neural activity or temporal coherence, we employed the newly developed regional homogeneity (ReHo) approach to determine aberrant functional connectivity using the chronic unpredictable mild stress (CUMS) mouse model of depression and to also explore the brain‐region rescue effect of modified Xiaoyaosan (MXYS) in such mice. We found the aberrant ReHo in CUMS mice replicated previous discoveries in patients with depression. Intriguingly, MXYS only normalized several limbic regions, which suggests the essential roles of these regions in mediating the antidepressant effects of MXYS. Our results provide a reliable framework for the use of ReHo analysis with animal models of depression and further suggest a new perspective to elucidate the antidepressant effects of MXYS. |
| doi_str_mv | 10.1111/neup.12540 |
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We analyzed blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOLD signals and analyze the intra‐region neural activity or temporal coherence, we employed the newly developed regional homogeneity (ReHo) approach to determine aberrant functional connectivity using the chronic unpredictable mild stress (CUMS) mouse model of depression and to also explore the brain‐region rescue effect of modified Xiaoyaosan (MXYS) in such mice. We found the aberrant ReHo in CUMS mice replicated previous discoveries in patients with depression. Intriguingly, MXYS only normalized several limbic regions, which suggests the essential roles of these regions in mediating the antidepressant effects of MXYS. Our results provide a reliable framework for the use of ReHo analysis with animal models of depression and further suggest a new perspective to elucidate the antidepressant effects of MXYS.</description><identifier>ISSN: 0919-6544</identifier><identifier>EISSN: 1440-1789</identifier><identifier>DOI: 10.1111/neup.12540</identifier><identifier>PMID: 30834629</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Animal models ; Animals ; Antidepressants ; Antidepressive Agents - administration & dosage ; Brain - drug effects ; Brain - physiopathology ; Brain Mapping ; depression ; Depression - drug therapy ; Depression - physiopathology ; Disease Models, Animal ; Drugs, Chinese Herbal - administration & dosage ; fMRI ; Functional magnetic resonance imaging ; Herbal medicine ; hippocampus ; Magnetic Resonance Imaging ; Male ; Mental depression ; Mice, Inbred C57BL ; MXYS ; Neural networks ; Neuroimaging ; regional homogeneity</subject><ispartof>Neuropathology, 2019-04, Vol.39 (2), p.85-96</ispartof><rights>2019 Japanese Society of Neuropathology</rights><rights>2019 Japanese Society of Neuropathology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3810-1bcbfa51a1e7d0d29f17c12af953c0d5771da95a56f1f092c3d6ae76b63c27573</citedby><cites>FETCH-LOGICAL-c3810-1bcbfa51a1e7d0d29f17c12af953c0d5771da95a56f1f092c3d6ae76b63c27573</cites><orcidid>0000-0003-2796-526X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fneup.12540$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fneup.12540$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30834629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bi, Yanmeng</creatorcontrib><creatorcontrib>Huang, Peng</creatorcontrib><creatorcontrib>Dong, Zhaoyang</creatorcontrib><creatorcontrib>Gao, Tingting</creatorcontrib><creatorcontrib>Huang, Shaohui</creatorcontrib><creatorcontrib>Gao, Lei</creatorcontrib><creatorcontrib>Lv, Zhiping</creatorcontrib><title>Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice</title><title>Neuropathology</title><addtitle>Neuropathology</addtitle><description>The aim of this study is to explore the macroscale neural mechanisms of the antidepressant effects of Xiaoyaosan, a traditional Chinese herbal formula. We analyzed blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOLD signals and analyze the intra‐region neural activity or temporal coherence, we employed the newly developed regional homogeneity (ReHo) approach to determine aberrant functional connectivity using the chronic unpredictable mild stress (CUMS) mouse model of depression and to also explore the brain‐region rescue effect of modified Xiaoyaosan (MXYS) in such mice. We found the aberrant ReHo in CUMS mice replicated previous discoveries in patients with depression. Intriguingly, MXYS only normalized several limbic regions, which suggests the essential roles of these regions in mediating the antidepressant effects of MXYS. Our results provide a reliable framework for the use of ReHo analysis with animal models of depression and further suggest a new perspective to elucidate the antidepressant effects of MXYS.</description><subject>Animal models</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - administration & dosage</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>depression</subject><subject>Depression - drug therapy</subject><subject>Depression - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>fMRI</subject><subject>Functional magnetic resonance imaging</subject><subject>Herbal medicine</subject><subject>hippocampus</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mental depression</subject><subject>Mice, Inbred C57BL</subject><subject>MXYS</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>regional homogeneity</subject><issn>0919-6544</issn><issn>1440-1789</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EFLHDEUB_BQlLraXvoBJOBFhNW8zGQyOcpiq2C1hy70NmSSF43MTNZkRrvfvll320MP5vIg_PLn5U_IF2DnkM_FgNPqHLgo2Qcyg7Jkc5C12iMzpkDNK1GWB-QwpSfGQCpefyQHBauLsuJqRh6_B-udR0t_eR3WOiQ90IgvGBMmqluMUQ8jbaP2m_sHHwbd0cfQhwcc0I9rOgaKvzGONDtvcRUxJf-CFJ1DMyaa3_Xe4Cey73SX8PNuHpHl16ufi-v57f23m8Xl7dwUNeTNW9M6LUADSsssVw6kAa6dEoVhVkgJViuhReXAMcVNYSuNsmqrwnApZHFETre5qxieJ0xj0_tksOv0gGFKDYe65ix3IjI9-Y8-hSnm_2XFGQgGBVRZnW2ViSGliK5ZRd_ruG6ANZv-m03_zVv_GR_vIqe2R_uP_i08A9iCV9_h-p2o5u5q-WMb-gc-DJFr</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Bi, Yanmeng</creator><creator>Huang, Peng</creator><creator>Dong, Zhaoyang</creator><creator>Gao, Tingting</creator><creator>Huang, Shaohui</creator><creator>Gao, Lei</creator><creator>Lv, Zhiping</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2796-526X</orcidid></search><sort><creationdate>201904</creationdate><title>Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice</title><author>Bi, Yanmeng ; Huang, Peng ; Dong, Zhaoyang ; Gao, Tingting ; Huang, Shaohui ; Gao, Lei ; Lv, Zhiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3810-1bcbfa51a1e7d0d29f17c12af953c0d5771da95a56f1f092c3d6ae76b63c27573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - administration & dosage</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>depression</topic><topic>Depression - drug therapy</topic><topic>Depression - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>fMRI</topic><topic>Functional magnetic resonance imaging</topic><topic>Herbal medicine</topic><topic>hippocampus</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mental depression</topic><topic>Mice, Inbred C57BL</topic><topic>MXYS</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>regional homogeneity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bi, Yanmeng</creatorcontrib><creatorcontrib>Huang, Peng</creatorcontrib><creatorcontrib>Dong, Zhaoyang</creatorcontrib><creatorcontrib>Gao, Tingting</creatorcontrib><creatorcontrib>Huang, Shaohui</creatorcontrib><creatorcontrib>Gao, Lei</creatorcontrib><creatorcontrib>Lv, Zhiping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bi, Yanmeng</au><au>Huang, Peng</au><au>Dong, Zhaoyang</au><au>Gao, Tingting</au><au>Huang, Shaohui</au><au>Gao, Lei</au><au>Lv, Zhiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice</atitle><jtitle>Neuropathology</jtitle><addtitle>Neuropathology</addtitle><date>2019-04</date><risdate>2019</risdate><volume>39</volume><issue>2</issue><spage>85</spage><epage>96</epage><pages>85-96</pages><issn>0919-6544</issn><eissn>1440-1789</eissn><abstract>The aim of this study is to explore the macroscale neural mechanisms of the antidepressant effects of Xiaoyaosan, a traditional Chinese herbal formula. We analyzed blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOLD signals and analyze the intra‐region neural activity or temporal coherence, we employed the newly developed regional homogeneity (ReHo) approach to determine aberrant functional connectivity using the chronic unpredictable mild stress (CUMS) mouse model of depression and to also explore the brain‐region rescue effect of modified Xiaoyaosan (MXYS) in such mice. We found the aberrant ReHo in CUMS mice replicated previous discoveries in patients with depression. Intriguingly, MXYS only normalized several limbic regions, which suggests the essential roles of these regions in mediating the antidepressant effects of MXYS. Our results provide a reliable framework for the use of ReHo analysis with animal models of depression and further suggest a new perspective to elucidate the antidepressant effects of MXYS.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>30834629</pmid><doi>10.1111/neup.12540</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2796-526X</orcidid></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animal models Animals Antidepressants Antidepressive Agents - administration & dosage Brain - drug effects Brain - physiopathology Brain Mapping depression Depression - drug therapy Depression - physiopathology Disease Models, Animal Drugs, Chinese Herbal - administration & dosage fMRI Functional magnetic resonance imaging Herbal medicine hippocampus Magnetic Resonance Imaging Male Mental depression Mice, Inbred C57BL MXYS Neural networks Neuroimaging regional homogeneity |
| title | Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice |
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