A novel STIM1-Orai1 gating interface essential for CRAC channel activation

[Display omitted] •A short domain within the SOAR fragment of STIM1 is involved in transmitting the activation action of STIM1 to Orai1.•This domain contributes to a STIM1-Orai1 gating interface, separating STIM1 coupling to Orai1 from gating of Orai1.•The formation of a STIM1-Orai1 gating interface...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2019-05, Vol.79, p.57-67
Hauptverfasser:	Butorac, Carmen, Muik, Martin, Derler, Isabella, Stadlbauer, Michael, Lunz, Victoria, Krizova, Adéla, Lindinger, Sonja, Schober, Romana, Frischauf, Irene, Bhardwaj, Rajesh, Hediger, Matthias A., Groschner, Klaus, Romanin, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium Release Activated Calcium Channels - metabolism Cells, Cultured Cloning, Molecular CRAC channel gating Fluorescence microscopy HEK293 Cells Humans Neoplasm Proteins - deficiency Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Orai1 ORAI1 Protein - deficiency ORAI1 Protein - genetics ORAI1 Protein - metabolism Patch-clamp STIM1 Stromal Interaction Molecule 1 - deficiency Stromal Interaction Molecule 1 - genetics Stromal Interaction Molecule 1 - metabolism
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