Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress

Vascular calcification is associated with cardiovascular death in patients with chronic kidney disease (CKD). Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) plays an important role in various cardiovascular diseases. However, its role in vascular calcification remains unknown....

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Veröffentlicht in:	Antioxidants & redox signaling 2019-07, Vol.31 (1), p.75-91
Hauptverfasser:	Feng, Han, Wang, Jin-Yu, Yu, Bo, Cong, Xin, Zhang, Wei-Guang, Li, Li, Liu, Li-Mei, Zhou, Yun, Zhang, Cheng-Lin, Gu, Pei-Liang, Wu, Li-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Aorta Arteries Arteriosclerosis Calcification Calcification (ectopic) Calcium Cardiovascular diseases Clonal deletion Coronary vessels Depletion Deposition Femoral artery Femur Gene expression Glycerophosphate Heart diseases Kidney diseases Mitochondria Muscles Nodules Oxidative stress Reactive oxygen species Reduction siRNA Smooth muscle Superoxide dismutase
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