Optimization of process variables for increased production of lovastatin in Aspergillus terreus PU-PCSIR1 and its characterization

During intrinsic cholesterol formation 3-hydroxy-3-methylgutaryl coenzyme A reductase (HMGCR) converts HMGCoA to mevalonate, in biosynthetic cascade of cholesterol. Statins, competitive inhibitors of HMGCR, now-a-days commonly used to lower the blood-cholesterol level in the hyper-cholesterolemic pa...

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Veröffentlicht in:	Pakistan journal of pharmaceutical sciences 2019-01, Vol.32 (1(Supplementary)), p.363-370
Hauptverfasser:	Hassan, Abida, Saleem, Yasar, Chaudhry, Muhammad Nawaz, Asghar, Amina, Saleem, Muhammad, Nawaz, Shaista, Syed, Quratulain, Iqbal, Muhammad Shaheen, Shahzad, Khurram
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus - metabolism Biotechnology - methods Carbon - metabolism Chromatography, High Pressure Liquid Dietary Fiber - metabolism Fermentation Glycerol - metabolism Glycine max Hydrogen-Ion Concentration Lovastatin - analysis Lovastatin - biosynthesis Nitrogen - metabolism Spectroscopy, Fourier Transform Infrared
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