Abnormal preschool Lung Clearance Index (LCI) reflects clinical status and predicts lower spirometry later in childhood in cystic fibrosis
AbstractBackgroundClinical and prognostic value of preschool Multiple Breath Washout (MBW) remains unclear. MethodsInitial MBW results (Exhalyzer® D, EcoMedics AG) in preschool Cystic Fibrosis (CF) subjects (age 2–6 years) at a time of clinical stability were compared to (1) concurrent clinical stat...
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| Veröffentlicht in: | Journal of cystic fibrosis 2019-09, Vol.18 (5), p.721-727 |
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| container_title | Journal of cystic fibrosis |
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| creator | Hardaker, K.M Panda, H Hulme, K Wong, A Coward, E Cooper, P Fitzgerald, D.A Pandit, C Towns, S Selvadurai, H Robinson, P.D |
| description | AbstractBackgroundClinical and prognostic value of preschool Multiple Breath Washout (MBW) remains unclear. MethodsInitial MBW results (Exhalyzer® D, EcoMedics AG) in preschool Cystic Fibrosis (CF) subjects (age 2–6 years) at a time of clinical stability were compared to (1) concurrent clinical status measures and (2) later spirometry outcomes. Abnormal Lung Clearance Index (LCI) was defined using published reference data (ULN for LCI 8.0). ResultsLCI was abnormal in 56% (28/50), with mean (SD) LCI 8.61(1.85) at age 4.71(1.3) years. Abnormal LCI was associated with higher dornase alfa use, previous positive bacterial cultures and pF508.del homozygous genotype. Later spirometry ( n = 44; mean (SD) 2.3(0.5) years after MBW) demonstrated that abnormal initial preschool LCI was a strong predictor of lower later spirometry outcomes. ConclusionAbnormal preschool LCI was associated with concurrent measures of clinical status and later spirometry deficits, suggesting early prognostic utility of MBW testing in this age range. |
| doi_str_mv | 10.1016/j.jcf.2019.02.007 |
| format | Article |
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MethodsInitial MBW results (Exhalyzer® D, EcoMedics AG) in preschool Cystic Fibrosis (CF) subjects (age 2–6 years) at a time of clinical stability were compared to (1) concurrent clinical status measures and (2) later spirometry outcomes. Abnormal Lung Clearance Index (LCI) was defined using published reference data (ULN for LCI 8.0). ResultsLCI was abnormal in 56% (28/50), with mean (SD) LCI 8.61(1.85) at age 4.71(1.3) years. Abnormal LCI was associated with higher dornase alfa use, previous positive bacterial cultures and pF508.del homozygous genotype. Later spirometry ( n = 44; mean (SD) 2.3(0.5) years after MBW) demonstrated that abnormal initial preschool LCI was a strong predictor of lower later spirometry outcomes. ConclusionAbnormal preschool LCI was associated with concurrent measures of clinical status and later spirometry deficits, suggesting early prognostic utility of MBW testing in this age range.</description><identifier>ISSN: 1569-1993</identifier><identifier>EISSN: 1873-5010</identifier><identifier>DOI: 10.1016/j.jcf.2019.02.007</identifier><identifier>PMID: 30827846</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cystic fibrosis ; Multiple breath washout ; Preschool ; Pulmonary/Respiratory ; Spirometry</subject><ispartof>Journal of cystic fibrosis, 2019-09, Vol.18 (5), p.721-727</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-394bbad922b4971f8912d001a7bb8071125bd62fdd6d0c76913fc3602daff6873</citedby><cites>FETCH-LOGICAL-c451t-394bbad922b4971f8912d001a7bb8071125bd62fdd6d0c76913fc3602daff6873</cites><orcidid>0000-0001-7397-105X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcf.2019.02.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30827846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hardaker, K.M</creatorcontrib><creatorcontrib>Panda, H</creatorcontrib><creatorcontrib>Hulme, K</creatorcontrib><creatorcontrib>Wong, A</creatorcontrib><creatorcontrib>Coward, E</creatorcontrib><creatorcontrib>Cooper, P</creatorcontrib><creatorcontrib>Fitzgerald, D.A</creatorcontrib><creatorcontrib>Pandit, C</creatorcontrib><creatorcontrib>Towns, S</creatorcontrib><creatorcontrib>Selvadurai, H</creatorcontrib><creatorcontrib>Robinson, P.D</creatorcontrib><title>Abnormal preschool Lung Clearance Index (LCI) reflects clinical status and predicts lower spirometry later in childhood in cystic fibrosis</title><title>Journal of cystic fibrosis</title><addtitle>J Cyst Fibros</addtitle><description>AbstractBackgroundClinical and prognostic value of preschool Multiple Breath Washout (MBW) remains unclear. MethodsInitial MBW results (Exhalyzer® D, EcoMedics AG) in preschool Cystic Fibrosis (CF) subjects (age 2–6 years) at a time of clinical stability were compared to (1) concurrent clinical status measures and (2) later spirometry outcomes. Abnormal Lung Clearance Index (LCI) was defined using published reference data (ULN for LCI 8.0). ResultsLCI was abnormal in 56% (28/50), with mean (SD) LCI 8.61(1.85) at age 4.71(1.3) years. Abnormal LCI was associated with higher dornase alfa use, previous positive bacterial cultures and pF508.del homozygous genotype. Later spirometry ( n = 44; mean (SD) 2.3(0.5) years after MBW) demonstrated that abnormal initial preschool LCI was a strong predictor of lower later spirometry outcomes. ConclusionAbnormal preschool LCI was associated with concurrent measures of clinical status and later spirometry deficits, suggesting early prognostic utility of MBW testing in this age range.</description><subject>Cystic fibrosis</subject><subject>Multiple breath washout</subject><subject>Preschool</subject><subject>Pulmonary/Respiratory</subject><subject>Spirometry</subject><issn>1569-1993</issn><issn>1873-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9Uk1v1DAUjBCIlsIP4IJ8LIekz07ixEJCqlYUVlqJQ8vZcmyHOjjxYieF_Qv86r6wLYceOPlrZp7fzMuytxQKCpRfDMWg-4IBFQWwAqB5lp3StinzGig8x33NRU6FKE-yVykNALSBpn2ZnZTQsqat-Gn257KbQhyVJ_tok74NwZPdMn0nG29VVJO2ZDsZ-5uc7zbb9yTa3ls9J6K9m5xGWprVvCSiJrMqGLc--vDLRpL2LobRzvFAvJrxwk1E3zpvsIj5ezik2WnSuy6G5NLr7EWvfLJvHtaz7NvVp5vNl3z39fN2c7nLdVXTOS9F1XXKCMa6SjS0bwVlBltTTde10FDK6s5w1hvDDeiGC1r2uuTAjOp7ju6cZedH3X0MPxebZjm6pK33arJhSZKhhaLmrGoRSo9QjT9M2LzcRzeqeJAU5BqBHCRGINcIJDCJESDn3YP80o3W_GM8eo6AD0eAxSbvnI0yaWfRaeMieitNcP-V__iE_RjFD3uwaQhLnNA9SWVCgrxeZ2AdASpKAFbz8h75gK1L</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Hardaker, K.M</creator><creator>Panda, H</creator><creator>Hulme, K</creator><creator>Wong, A</creator><creator>Coward, E</creator><creator>Cooper, P</creator><creator>Fitzgerald, D.A</creator><creator>Pandit, C</creator><creator>Towns, S</creator><creator>Selvadurai, H</creator><creator>Robinson, P.D</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7397-105X</orcidid></search><sort><creationdate>20190901</creationdate><title>Abnormal preschool Lung Clearance Index (LCI) reflects clinical status and predicts lower spirometry later in childhood in cystic fibrosis</title><author>Hardaker, K.M ; Panda, H ; Hulme, K ; Wong, A ; Coward, E ; Cooper, P ; Fitzgerald, D.A ; Pandit, C ; Towns, S ; Selvadurai, H ; Robinson, P.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-394bbad922b4971f8912d001a7bb8071125bd62fdd6d0c76913fc3602daff6873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cystic fibrosis</topic><topic>Multiple breath washout</topic><topic>Preschool</topic><topic>Pulmonary/Respiratory</topic><topic>Spirometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardaker, K.M</creatorcontrib><creatorcontrib>Panda, H</creatorcontrib><creatorcontrib>Hulme, K</creatorcontrib><creatorcontrib>Wong, A</creatorcontrib><creatorcontrib>Coward, E</creatorcontrib><creatorcontrib>Cooper, P</creatorcontrib><creatorcontrib>Fitzgerald, D.A</creatorcontrib><creatorcontrib>Pandit, C</creatorcontrib><creatorcontrib>Towns, S</creatorcontrib><creatorcontrib>Selvadurai, H</creatorcontrib><creatorcontrib>Robinson, P.D</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cystic fibrosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hardaker, K.M</au><au>Panda, H</au><au>Hulme, K</au><au>Wong, A</au><au>Coward, E</au><au>Cooper, P</au><au>Fitzgerald, D.A</au><au>Pandit, C</au><au>Towns, S</au><au>Selvadurai, H</au><au>Robinson, P.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal preschool Lung Clearance Index (LCI) reflects clinical status and predicts lower spirometry later in childhood in cystic fibrosis</atitle><jtitle>Journal of cystic fibrosis</jtitle><addtitle>J Cyst Fibros</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>18</volume><issue>5</issue><spage>721</spage><epage>727</epage><pages>721-727</pages><issn>1569-1993</issn><eissn>1873-5010</eissn><abstract>AbstractBackgroundClinical and prognostic value of preschool Multiple Breath Washout (MBW) remains unclear. MethodsInitial MBW results (Exhalyzer® D, EcoMedics AG) in preschool Cystic Fibrosis (CF) subjects (age 2–6 years) at a time of clinical stability were compared to (1) concurrent clinical status measures and (2) later spirometry outcomes. Abnormal Lung Clearance Index (LCI) was defined using published reference data (ULN for LCI 8.0). ResultsLCI was abnormal in 56% (28/50), with mean (SD) LCI 8.61(1.85) at age 4.71(1.3) years. Abnormal LCI was associated with higher dornase alfa use, previous positive bacterial cultures and pF508.del homozygous genotype. Later spirometry ( n = 44; mean (SD) 2.3(0.5) years after MBW) demonstrated that abnormal initial preschool LCI was a strong predictor of lower later spirometry outcomes. ConclusionAbnormal preschool LCI was associated with concurrent measures of clinical status and later spirometry deficits, suggesting early prognostic utility of MBW testing in this age range.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30827846</pmid><doi>10.1016/j.jcf.2019.02.007</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7397-105X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Cystic fibrosis Multiple breath washout Preschool Pulmonary/Respiratory Spirometry |
| title | Abnormal preschool Lung Clearance Index (LCI) reflects clinical status and predicts lower spirometry later in childhood in cystic fibrosis |
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