The Roles of Chemokine CXCL13 in the Development of Bone Cancer Pain and the Regulation of Morphine Analgesia in Rats

Chemokines are important regulators of immune, inflammatory, and neuronal responses in peripheral and central pain pathway. The aim of this study was to investigate whether chemokine (C-X-C motif) ligand 13 (CXCL13) and its receptor (C-X-C chemokine receptor type 5, CXCR5) involve in the development...

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Veröffentlicht in:	Neuroscience 2019-05, Vol.406, p.62-72
Hauptverfasser:	Bu, Hui-Lian, Xia, Yu-Zhong, Liu, Pan-Mei, Guo, Hai-Ming, Yuan, Chang, Fan, Xiao-Chong, Huang, Chen, Wen, Yuan-Yuan, Kong, Cun-Long, Wang, Tao, Ma, Le-Tian, Li, Xin-Xin, Zhang, Hong-Wei, Zhang, Li-Rong, Ma, Min-Yu, Ai, Yan-Qiu, Zhang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia - methods Analgesics, Opioid - administration & dosage Animals Bone Neoplasms - drug therapy Bone Neoplasms - metabolism cancer pain Cancer Pain - drug therapy Cancer Pain - metabolism Chemokine CXCL13 - administration & dosage CXCL13 Double-Blind Method Female Injections, Spinal morphine Morphine - administration & dosage Random Allocation Rats Rats, Sprague-Dawley signaling pathways siRNA Spinal Cord - drug effects Spinal Cord - metabolism
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